9 completed, 2 terminated. 11 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 9, Terminated 2 |
| Phase 1 | 4 | Completed 3, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Pentamidine: new trials by email Literature Review of Pentamidine trials Research Report on Pentamidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypertrophic Scar Prevention by Novel Topical Gel Application Pentamidine Isethionate, Placebo - Hypertrophic Scar | Phase 1 / Phase 2 | Terminated | Mayo Clinic | 6 | 2018-03-05 | 2023-11-22 |
| Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia Paromomycin Sulfate, Pentamidine Isethionate, Placebo - Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex | Phase 2 / Phase 3 | Completed | Fundacion Nacional de Dermatologia | 80 | 2017-04-15 | 2021-02-02 |
| Efficacy and Safety of Pentamidine (7mg/kg) for Patients With Cutaneous Leishmaniasis Caused by L. Guyanensis Single dose of Pentamidine, Two doses of Pentamidine, Three doses of Pentamidine - Cutaneous Leishmaniases | Phase 2 | Completed | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado | 159 | 2014-01-01 | 2019-02-15 |
| A Safety Study Using Pentamidine in Patients With Pancreatic Cancer Undergoing Standard Therapy Pentamidine - Pancreatic Cancer | Phase 1 / Phase 2 | Completed | Oncozyme Pharma Inc. | 10 | 2009-01-01 | 2011-06-28 |
| 0794GCC: Pentamidine in Treating Patients With Relapsed or Refractory Melanoma pentamidine - Melanoma (Skin) | Phase 2 | Terminated | University of Maryland, Baltimore | 6 | 2008-07-01 | 2019-08-16 |
| A Safety Study of Pentamidine in Patients With Metastatic Colon Cancer Undergoing Standard Chemotherapy as Second-line and/or Third-line Treatment pentamidine - Colorectal Cancer | Phase 1 / Phase 2 | Completed | Oncozyme Pharma Inc. | 15 | 2008-03-01 | 2011-06-28 |
| Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in Adults Alemtuzumab, Sirolimus, Tacrolimus - Kidney Transplantation, Kidney Disease | Phase 1 / Phase 2 | Completed | University of Wisconsin, Madison | 10 | 2003-11-01 | 2018-06-29 |
| Trial of DB289 for the Treatment of Stage I African Trypanosomiasis DB289, Pentamidine - African Trypanosomiasis | Phase 2 | Completed | Immtech Pharmaceuticals, Inc | 111 | 2003-02-01 | 2008-12-08 |
| Islet Transplantation for Type 1 Diabetes Islet Transplantation, Sirolimus, Tacrolimus - Diabetes Mellitus, Insulin-Dependent | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 36 | 2001-04-01 | 2017-03-15 |
| Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma Bleomycin Sulfate, Filgrastim, Cisplatin - Lymphoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 46 | 1993-06-01 | 2012-07-30 |
| A Phase II Open Randomized Comparison of 566C80 and Pentamidine Isethionate for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Who Are Intolerant of Trimethoprim / Sulfamethoxazole Atovaquone, Pentamidine isethionate - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 2 | Completed | Glaxo Wellcome | 2005-06-24 |
Leishmaniasis, Cutaneous (2) · Acquired Immunodeficiency Syndrome (1) · Cicatrix, Hypertrophic (1) · Colorectal Neoplasms (1) · Diabetes Mellitus, Type 1 (1) · HIV Infections (1) · Kidney Diseases (1) · Leishmaniasis (1) · Leishmaniasis, Mucocutaneous (1) · Lymphoma (1) · Melanoma (1) · Pancreatic Neoplasms (1) · Pneumonia, Pneumocystis (1) · Renal Insufficiency (1) · Trypanosomiasis, African (1)
Oncozyme Pharma Inc. (2) · Fundacion Nacional de Dermatologia (1) · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (1) · Glaxo Wellcome (1) · Immtech Pharmaceuticals, Inc (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · University of Maryland, Baltimore (1) · University of Wisconsin, Madison (1)
United States (6) · Canada (3) · Bolivia (1) · Germany (1) · Italy (1) · Republic of the Congo (1) · Switzerland (1)
Petr Kavan, MD, Ph.D. (2) · A. D'jamali, MD, MS (1) · Alexander Meves, MD (1) · Anette Talhari, Doctor (1) · Edward A. Sausville, MD, PhD (1) · James Shapiro, MD, PhD (1) · Peter W. McLaughlin, MD (1) · Victor Kande, MD (1)
PMID 15257060, PMID 17005949, PMID 23438305, PMID 26881924, PMID 29654388, PMID 30260376, PMID 30379814
P30CA016672 (1), R21CA135624 (1)