15 completed, 5 unknown, 1 terminated. 12 Phase 4, 5 Phase 3, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Completed 7, Unknown 4, Terminated 1 |
| Phase 3 | 5 | Completed 5 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intermediate and Long Acting Insulin Young Children Type 1 Diabetes. Degludec, Glargine, NPH insulin - Type 1 Diabetes Mellitus With Hypoglycemia, type1diabetes | Phase 4 | Unknown | Ain Shams University | 60 | 2019-02-21 | 2021-02-16 |
| Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia NPH Insulin, glargine, Insulin Aspart - Hyperglycemia Steroid-induced, Insulin Resistance, Diabetes | Phase 4 | Terminated | Northwestern University | 3 | 2018-03-27 | 2020-09-11 |
| Insulin Schemes for Type 2 Diabetes Control NPH insulin, Glargine and Lispro insulin - Type 2 Diabetes Mellitus | Phase 4 | Completed | Universidad de Guanajuato | 75 | 2017-11-02 | 2021-12-06 |
| A Study to Demonstrate Bioequivalence Between Insulin Glulisine U300 and Insulin Glulisine U100 After a Single Subcutaneous Dose Using the Euglycemic Clamp Technique, in Patients With Type 1 Diabetes Mellitus Insulin glulisine (U300), Insulin glulisine, Insulin aspart - Type1 Diabetes Mellitus | Phase 1 | Completed | Sanofi | 44 | 2017-02-17 | 2022-04-25 |
| A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulin in Patients Already Using Basal Insulin insulin glargine (U300), insulin glargine (U100), NPH insulin - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Sanofi | 609 | 2015-12-21 | 2022-04-25 |
| A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulins in Insulin Naïve Patients Initiating Insulin insulin glargine (U300), insulin glargine (U100), NPH insulin - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Sanofi | 705 | 2015-11-05 | 2022-04-25 |
| A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy (MK-8835-007). Ertugliflozin 5 mg, Ertugliflozin 15 mg, Placebo to Ertugliflozin - Type 2 Diabetes Mellitus | Phase 3 | Completed | Merck Sharp & Dohme LLC | 621 | 2013-12-13 | 2018-09-10 |
| Glargine Versus NPH in Patients With Chronic Kidney Disease Glargine insulin, NPH insulin - Type 2 Diabetes Mellitus, Chronic Kidney Disease | Phase 4 | Completed | University of Sao Paulo General Hospital | 34 | 2013-12-01 | 2017-12-20 |
| Establishing Cardiovascular Biomarkers to Define Preferred Lantus® Use nph insulin, human insulin, Insulin Glargine - Insulin-requiring Type 2 Diabetes Mellitus | Phase 4 | Unknown | ikfe-CRO GmbH | 60 | 2011-10-01 | 2011-12-29 |
| Efficacy and Safety of Insulin Glargine Versus. Neutral Protamine Hagedorn (NPH) Insulin in Children With Type 1 Diabetes Above 6 Years Old. Insulin glargine (HOE901), NPH insulin - Type 1 Diabetes Mellitus | Phase 3 | Completed | Sanofi | 162 | 2011-02-01 | 2014-04-01 |
| The Effects of Short-Term Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients Exenatide, Humulin-N - Type 2 Diabetes | Phase 4 | Unknown | Taipei Veterans General Hospital, Taiwan | 160 | 2010-11-01 | 2013-06-27 |
| The Management of Glucocorticoid-Induced Hyperglycemia in Hospitalized Patients Glargine insulin, Lispro insulin, NPH Insulin - Hyperglycemia, Diabetes Mellitus | Phase 4 | Completed | Baylor College of Medicine | 37 | 2010-09-01 | 2017-02-08 |
| Sitagliptin (DPP-4 Inhibitor) and NPH Insulin in Patients With T2D sitagliptin, NPH insulin - Type 2 Diabetes Mellitus | Phase 4 | Completed | University of Sao Paulo General Hospital | 40 | 2010-01-01 | 2015-11-18 |
| Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes Metformin, Insulin - Non Insulin Dependent Diabetes, Pregnancy | Phase 2 | Completed | University of North Carolina, Chapel Hill | 31 | 2008-08-01 | 2017-04-25 |
| Beta-Cell Function of Insulin Glargine Compared to Neutral Protamine Hagedorn (NPH) Insuline and to Insulin Detemir in Combination With Metformin Insulin Glargin, NPH insulin, Insulin detemir - Type 2 Diabetic Patients, Insufficient Metabolic Control | Phase 4 | Completed | ikfe-CRO GmbH | 30 | 2008-04-01 | 2009-07-17 |
| Efficacy and Safety of Insulin Detemir Versus Neutral Protamine Hagedorn (NPH) Insulin in Pregnant Women With Type 1 Diabetes insulin detemir, NPH insulin, insulin aspart - Diabetes, Diabetes Mellitus, Type 1 | Phase 3 | Completed | Novo Nordisk A/S | 470 | 2007-05-01 | 2017-03-10 |
| Glycemic And Blood Pressure Control In Type 2 Diabetes, In A Primary Care Unit: A Staged Management Strategy Metformin, Glybenclamide, NPH insulin - Diabetes Mellitus, Arterial Hypertension | Unknown | Hospital de Clinicas de Porto Alegre | 124 | 2006-07-01 | 2011-10-26 | |
| Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis NPH insulin, Glargine, Detemir - Diabetes Mellitus Type 1 | Phase 4 | Unknown | Karolinska Institutet | 120 | 2005-09-01 | 2011-01-06 |
| Comparison of the Ability of Glulisine With Lispro to Control Type 1 Diabetes Mellitus in Children and Adolescents Insulin glulisine, insulin lispro, insulin glargine - Diabetes Mellitus, Insulin-Dependent | Phase 3 | Completed | Sanofi | 572 | 2005-04-01 | 2016-05-20 |
| Comparison of Insulin Glargine and NPH Insulin at Night and at Hypoglycemia in Type 2 Diabetes insulin glargine, NPH insulin - Diabetes | Completed | University of Giessen | 12 | 2003-07-01 | 2007-08-30 |
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Diabetes Mellitus, Type 2 (9) · Diabetes Mellitus (6) · Diabetes Mellitus, Type 1 (5) · Hyperglycemia (2) · Hypoglycemia (2) · Hypertension (1) · Insulin Resistance (1) · Renal Insufficiency, Chronic (1)
Sanofi (5) · Novo Nordisk A/S (2) · University of Sao Paulo General Hospital (2) · ikfe-CRO GmbH (2) · Ain Shams University (1) · Baylor College of Medicine (1) · Hospital de Clinicas de Porto Alegre (1) · Karolinska Institutet (1) · Merck Sharp & Dohme LLC (1) · Northwestern University (1) · Taipei Veterans General Hospital, Taiwan (1) · Universidad de Guanajuato (1) · University of Giessen (1) · University of North Carolina, Chapel Hill (1)
Brazil (6) · Germany (5) · France (4) · Ireland (4) · United Kingdom (4) · United States (4) · Finland (3) · Spain (3) · Australia (2) · Denmark (2) · Norway (2) · Romania (2) · Sweden (2) · Argentina (1) · Austria (1)
Ashley Hickman, MD (1) · Glenn R Cunningham, MD (1) · Harn-Shen Chen, MD, PhD (1) · Jorge L Gross, MD, PhD (1) · Jose A Alvarez, PhD (1) · Marcia S Queiroz, MD, PhD (1) · Maria ER Siva, MD, PhD (1) · Mark Molitch, MD (1) · Rogerio Friedman, MD, PhD (1) · Safinaz El Habashy (1)
PMID 33166419, PMID 31865758, PMID 15220016, PMID 19885233, PMID 20415692, PMID 21387555, PMID 21557440, PMID 22784834, PMID 22851598, PMID 23096052, PMID 23617228, PMID 26474657, PMID 27887605, PMID 27995731, PMID 28857451, PMID 30614616, PMID 31064361, PMID 31383366, PMID 31797522, PMID 32236732, PMID 32324065, PMID 32324082, PMID 32372382, PMID 32648108, PMID 34213819, PMID 36763328, PMID 42290292
2015 (2), 2016 (1)