24 completed, 11 recruiting, 5 not yet recruiting, 2 active not recruiting. 10 Not applicable, 10 Phase 2, 10 Phase 3, 10 Phase 4, 8 Phase 1.
Follow Normal Saline (Placebo): new trials by email Literature Review of Normal Saline (Placebo) trials Research Report on Normal Saline (Placebo)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Single and Dual Silver Fluoride Application 38% Silver Fluoride (Riva Star Aqua), Normal Saline (Placebo) - Dentine Caries | Phase 3 | Not yet recruiting | University of Malaya | 148 | 2026-10-01 | 2026-08-31 |
| Comparison of the Efficacy of Different Analgesic Strategies for Pain Control After Laparoscopic Cholecystectomy (LC) Low pneumoperitoneum, Local anaesthetic instillation to gallbladder bed, Normal Saline (Placebo) - Gallstones, Pain | Not applicable | Active not recruiting | Assiut University | 200 | 2026-08-01 | 2026-10-27 |
| SkyVaricella® (NBP608) Vaccine With Lower Potencies in Healthy Children Aged 12 Months to 12 Years NBP608 (Mid Potency), NBP608 (Low Potency), Varivax® - Varicella (Chickenpox) | Phase 3 | Recruiting | SK Bioscience Co., Ltd. | 780 | 2026-07-04 | 2026-09-15 |
| Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery Tranexamic Acid (Topical), Normal Saline (Placebo) - Cesarean Delivery, Postpartum Hemorrhage (PPH) | Early Phase 1 | Recruiting | Wolfson Medical Center | 112 | 2026-07-01 | 2026-07-02 |
| Effect of Ipratropium Bromide on EILO Ipratropium Bromide, Normal Saline (Placebo) - Exercise-Induced Laryngeal Obstruction, Dyspnea During Activity | Phase 2 | Not yet recruiting | Cook Children's Health Care System | 50 | 2026-06-01 | 2026-05-05 |
| rhBNP for Prevention of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) Recombinant Human Brain Natriuretic Peptide (rhBNP), Normal Saline (Placebo) - AKI - Acute Kidney Injury, Cardiac Surgical Procedures | Phase 4 | Not yet recruiting | China National Center for Cardiovascular Diseases | 694 | 2026-05-01 | 2026-06-01 |
| Safety, Tolerability and Efficacy of PfSPZ-LARC2 Vaccine Against CHMI in Malaria-Naïve Adults Normal Saline (Placebo), PfSPZ-LARC2 Vaccine, PfSPZ Challenge (7G8) - Malaria Falciparum | Phase 1 | Recruiting | Sanaria Inc. | 42 | 2026-03-12 | 2026-11-03 |
| Intra-Articular PRP Versus Dexamethasone for TMJ Internal Derangement Platelet-Rich Plasma (PRP), Dexamethasone with Local Anaesthetic, Normal Saline (Placebo) - Temporomandibular Joint Disorders, Temporomandibular Joint Internal Derangement | Not applicable | Completed | University Of Anbar | 30 | 2025-12-10 | 2026-07-09 |
| Efficacy of Two Ultrasound-guided Intra-articular Injections of Botox® Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis. OnabotulinumtoxinA, Normal saline (placebo) - Base-of-thumb Osteoarthritis, Osteoarthritis | Phase 2 / Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 120 | 2025-12-03 | 2026-04-03 |
| IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study Ferric carboxymaltose IV, Normal Saline (Placebo) - Scoliosis Correction, Iron Deficiency | Phase 2 / Phase 3 | Recruiting | Columbia University | 120 | 2025-11-21 | 2025-11-26 |
| Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries Dexmedetomidine, Normal Saline (Placebo) - Aki After Ascending Aortic Surgeries | Phase 1 | Active not recruiting | Ain Shams University | 78 | 2025-11-01 | 2026-06-09 |
| Prevention and Treatment for Bruises in Patients With Ischemic Stroke Ascorbic acid (Vitamin C), Normal Saline (Placebo) - Stroke, Bruises | Phase 4 | Not yet recruiting | Chiayi Christian Hospital | 400 | 2025-08-01 | 2025-02-13 |
| Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL, Normal Saline (Placebo) - Percutaneous Coronary Intervention, Peripheral Endovascular Intervention | Phase 4 | Recruiting | Duke University | 6000 | 2025-07-23 | 2026-10-29 |
| A Phase 1/2a to Evaluate the Safety and Efficacy of Adipose Tissue Allograft (BRC-OA) in Patients With Osteoarthritis of the Knee Cryopreserved Devitalized Adipose Tissue Allograft, Normal Saline (Placebo) - Osteoarthritis of Knee | Phase 1 / Phase 2 | Completed | Britecyte | 46 | 2025-05-05 | 2026-09-08 |
| Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures Normal Saline (Placebo), Lidocaine Intravenous Infusion, Remimazolam Tosilate - Disease of Respiratory System | Not applicable | Completed | Harbin Medical University | 153 | 2025-03-14 | 2026-10-19 |
| Age De-escalation Safety Trial of PfSPZ-LARC2 Vaccine in Burkina Faso PfSPZ-LARC2 Vaccine, Normal Saline (Placebo) - Malaria Falciparum, Malaria Infection | Phase 1 | Completed | Sanaria Inc. | 75 | 2025-03-04 | 2026-04-16 |
| A Study to Assess the Safety, Reactogenicity, and Immunogenicity of SK Japanese Encephalitis Messenger Ribonucleic Acid (mRNA) Vaccines (GBP560) in Healthy Adults GBP560-A, GBP560-B, IXIARO - Japanese Encephalitis Virus Disease | Phase 1 / Phase 2 | Completed | SK Bioscience Co., Ltd. | 161 | 2025-02-24 | 2026-09-11 |
| Investigating the Efficacy and Safety of Neoadjuvant Intravesical Instillation of Mitomycin C in Treating High-risk NMIBC Patients Mitomycin C (MMC), Normal Saline (Placebo) - Non-Muscle-Invasive Bladder Cancer (NMIBC) | Phase 3 | Recruiting | Shaogang Wang | 180 | 2025-02-17 | 2025-02-19 |
| Dexmedetomidine and Bupivacaine Intra-articular for Postoperative Analgesia After Knee Arthroscopic Surgery Normal Saline (Placebo), Bupivacaine 0.25%, Dexmedetomidine - Post Operative Analgesia | Phase 3 | Recruiting | Al-Azhar University | 75 | 2024-12-01 | 2025-04-22 |
| FMT for Insomnia Disorder (FMT-SLEEP) Faecal Microbiota Transplantation, Normal Saline (Placebo) - Chronic Insomnia Disorder | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 74 | 2024-11-01 | 2024-09-23 |
Showing 20 of 44. Sign in to see all of them.
Malaria (3) · Malaria, Falciparum (3) · Cerebral Palsy (2) · Hemorrhage (2) · Muscle Spasticity (2) · Pain (2) · Postpartum Hemorrhage (2) · Stroke (2) · Acute Kidney Injury (1) · Agnosia (1) · Blood Loss, Surgical (1) · Brain Injuries, Traumatic (1) · Cardiovascular Diseases (1) · Chickenpox (1) · Colonic Neoplasms (1)
Allergan (5) · Sanaria Inc. (3) · Liaquat National Hospital & Medical College (2) · SK Bioscience Co., Ltd. (2) · Ain Shams University (1) · Al-Azhar University (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · B.P. Koirala Institute of Health Sciences (1) · Britecyte (1) · Chiayi Christian Hospital (1) · China National Center for Cardiovascular Diseases (1) · Chinese University of Hong Kong (1) · Columbia University (1) · Cook Children's Health Care System (1)
United States (14) · Canada (5) · Egypt (4) · Pakistan (4) · Australia (3) · China (3) · Philippines (3) · Poland (3) · South Korea (3) · Thailand (3) · Turkey (Türkiye) (3) · Hungary (2) · Russia (2) · Burkina Faso (1) · France (1)
Rozalina Dimitrova (2) · Alla Danilkovitch (1) · Amichai Rottenstreich (1) · Boris D Heifets, MD, PhD (1) · Daniel A Emmert, MD PhD (1) · Deborah Dudgeon, MD, FRCPC (1) · Demetrios J. Kutsogiannis, MD MHS FRCPC (1) · Denis E O'Donnell, MD, FRCPC (1) · Eric Jacobsohn, MB ChB (1) · Erin Wright, MD (1) · George A Mashour, MD PhD (1) · Ghulam Murtaza, MBBS, FCPS, MRCS, MSc (epi) (1)
PMID 11573006, PMID 14671251, PMID 16078959, PMID 19003734, PMID 19558476, PMID 19874953, PMID 20083041, PMID 21916138, PMID 22569484, PMID 24284213, PMID 25185110, PMID 26140855, PMID 26694209, PMID 26756058, PMID 26988952, PMID 27230645, PMID 27745812, PMID 27843871, PMID 28576285, PMID 29040244, PMID 29438525, PMID 29766750, PMID 29943719, PMID 29995458, PMID 30232617, PMID 30336852, PMID 30524741, PMID 30589927, PMID 30768457, PMID 31610718, PMID 32045513, PMID 32681472, PMID 32754902, PMID 32809003, PMID 33517432, PMID 34448547, PMID 34495877, PMID 35131720, PMID 35164991, PMID 35306630, PMID 35852267, PMID 36156315, PMID 36762865, PMID 37205558, PMID 37278679, PMID 37806002, PMID 38188539, PMID 42432924, PMID 42800498, PMID 7787644
2008 (1)