10 completed, 3 terminated, 2 recruiting, 2 unknown. 17 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 17 | Completed 10, Terminated 3, Recruiting 2, Unknown 2 |
| Phase 2 | 1 | Completed 1 |
Follow Norethindrone Acetate: new trials by email Literature Review of Norethindrone Acetate trials Research Report on Norethindrone Acetate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Medical Management Following Excisional Surgery for Endometriosis: A Randomized Controlled Trial 40 mg relugolix, 1 mg estradiol, 0.5 mg norethindrone acetate - Endometriosis | Phase 3 | Recruiting | Main Line Health | 110 | 2024-08-15 | 2026-06-12 |
| Micronized Progesterone Versus Norethisterone Acetate in Combination With Estrogen as Menopausal Hormone Therapy Micronized progesterone in continuous combination with oral estrogen, Norethisterone acetate in continuous combination with oral estrogen - Menopausal Symptoms | Phase 3 | Recruiting | Angelica Lindén Hirschberg | 520 | 2022-03-15 | 2024-06-04 |
| Cannabidiol and Management of Endometriosis Pain Cannabidiol (CBD) Extract, Norethindrone Acetate, Placebo - Endometriosis, CBD | Phase 3 | Terminated | Milton S. Hershey Medical Center | 12 | 2020-12-04 | 2025-04-04 |
| Effects of Tranexemic Acid Versus Norethisterone Acetate on Endometrial Vasculature . norethisterone acetate, tranexamic acid tablets - Dysfunctional Uterine Bleeding | Phase 3 | Unknown | Cairo University | 120 | 2020-04-22 | 2020-03-16 |
| Low-Dose Naltrexone in Combination With Standard Treatment in Women With Endometriosis Naltrexone, Norethindrone Acetate, Placebo - Endometriosis | Phase 3 | Terminated | Milton S. Hershey Medical Center | 9 | 2020-01-16 | 2022-11-03 |
| A Study to Evaluate Safety and Efficacy of Elagolix in Participants With Endometriosis With Associated Moderate to Severe Pain elagolix, estradiol/norethindrone acetate (E2/NETA) - Endometriosis | Phase 3 | Terminated | AbbVie | 11 | 2017-12-27 | 2019-11-27 |
| Long-Term Safety Study of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Elagolix, Estradiol /norethindrone acetate (E2/NETA), E2/NETA Placebo - Heavy Menstrual Bleeding, Uterine Fibroids | Phase 3 | Completed | AbbVie | 478 | 2017-09-13 | 2025-07-22 |
| Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women (Replicate Study) Elagolix, Placebo for Estradiol/Norethindrone Acetate, Estradiol/Norethindrone Acetate - Uterine Fibroids, Heavy Menstrual Bleeding | Phase 3 | Completed | AbbVie | 378 | 2016-02-03 | 2021-07-13 |
| Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Elagolix, Placebo for Estradiol/Norethindrone Acetate, Estradiol/Norethindrone Acetate - Uterine Fibroids, Heavy Menstrual Bleeding | Phase 3 | Completed | AbbVie | 413 | 2015-12-22 | 2020-06-29 |
| Ovulation Incidence in Oral Contraceptive Users Ethinyl Estradiol, Norethindrone acetate, ferrous fumarate, Norethindrone - Contraception, Ovulation | Phase 3 | Completed | University of Southern California | 58 | 2014-08-01 | 2025-12-26 |
| Efficacy and Safety Study of Norethindrone Acetate Transdermal Delivery System in Contraception Norethindrone Acetate - Contraceptive Usage | Phase 3 | Completed | Watson Pharmaceuticals | 1659 | 2010-05-01 | 2013-09-19 |
| Study of Safety and Efficacy of an Oral Contraceptive Norethindrone acetate/ethinyl estradiol - Contraception | Phase 3 | Completed | Warner Chilcott | 1683 | 2006-11-01 | 2013-04-22 |
| Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg) Norethindrone Acetate (NA), GnRH Agonist (Lupron Depot) - Endometriosis, Dysmenorrhea | Phase 3 | Unknown | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 112 | 2004-08-01 | 2012-10-25 |
| Bleed Free Treatment of Menopausal Symptoms With New Ultra Low Dose Hormonal Combinations 0.5 mg estradiol / 0.1 mg norethisterone acetate (NETA), 0.5 mg estradiol / 0.25 mg norethisterone acetate (NETA), placebo - Menopause, Menopausal Vasomotor Symptoms | Phase 3 | Completed | Novo Nordisk A/S | 576 | 2004-05-28 | 2017-02-23 |
| Study of Safety and Efficacy of an Oral Contraceptive Norethindrone Acetate/Ethinyl Estradiol 24 Days, Norethindrone Acetate /Ethinyl Estradiol 21 Days - Prevention of Pregnancy | Phase 3 | Completed | Warner Chilcott | 938 | 2004-01-01 | 2013-04-22 |
| Efficiency of Gonadotropin-releasing Hormone (GnRH) Agonist in Preventing Chemotherapy Induced Ovarian Failure Triptorelin, Norethisterone acetate - Fertility Preservation, Alkylating Agents | Phase 2 / Phase 3 | Completed | Erasme University Hospital | 118 | 2002-07-01 | 2015-10-30 |
| Hormone Replacement Therapy and the Risk of Breast Cancer Recurrence in Women With Previous Early Stage Breast Cancer therapeutic estradiol, norethindrone acetate - Breast Cancer, Menopausal Symptoms | Phase 3 | Completed | Regional Oncologic Center | 1300 | 1997-09-01 | 2013-09-20 |
Endometriosis (5) · Leiomyoma (3) · Menorrhagia (3) · Pelvic Pain (3) · Dysmenorrhea (2) · Breast Carcinoma In Situ (1) · Breast Neoplasms (1) · Contraception Behavior (1) · Dyspareunia (1) · Hot Flashes (1) · Lymphoma (1) · Metrorrhagia (1)
AbbVie (4) · Milton S. Hershey Medical Center (2) · Warner Chilcott (2) · Angelica Lindén Hirschberg (1) · Cairo University (1) · Erasme University Hospital (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Main Line Health (1) · Novo Nordisk A/S (1) · Regional Oncologic Center (1) · University of Southern California (1) · Watson Pharmaceuticals (1)
United States (12) · Sweden (3) · Belgium (2) · Canada (2) · Finland (2) · France (2) · Norway (2) · Puerto Rico (2) · Switzerland (2) · Austria (1) · Denmark (1) · Germany (1) · Italy (1) · Poland (1) · United Kingdom (1)
Herman Ellman, MD (2) · Brian T Nguyen, MD, MSc (1) · C. Rageth, MD, PD (1) · Janusz Jaskiewicz, MD (1) · Jonas Bergh, MD, PhD (1) · Jordan Klebanoff, MD (1) · Kim E Caramelli, MS (1) · Kristin Riley, MD (1) · Lars Holmberg, MD, PhD (1) · Ozgul Muneyyirci-Delale, M.D. (1) · Yvon Englert, MD, PhD (1)
PMID 31971678, PMID 33650259, PMID 34553161, PMID 34582715, PMID 34878624, PMID 39381651, PMID 14962527, PMID 17453860, PMID 17487652, PMID 18202966, PMID 18364505, PMID 23129737, PMID 23921878, PMID 26410176, PMID 32702363, PMID 39448218, PMID 41307293, PMID 42695385
2004 (1)