14 completed, 3 recruiting, 1 not yet recruiting, 1 unknown. 19 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 19 | Completed 14, Recruiting 3, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 4 | Completed 3, Recruiting 1 |
Follow Mitomycin C: new trials by email Literature Review of Mitomycin C trials Research Report on Mitomycin C
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| In-home Intravesical Chemotherapy for the Treatment of Bladder Cancer, INVITE Trial BCG Solution, Cystoscopy, Docetaxel - Non-Muscle Invasive Bladder Carcinoma, Stage 0a Bladder Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 40 | 2025-04-21 | 2026-10-08 |
| Intravesical Mitomycin C After Diagnostic Ureteroscopy for Upper Tract Urothelial Carcinoma Mitomycin C - Urothelial Carcinoma Ureter, Urothelial Cancer of Renal Pelvis | Phase 1 | Not yet recruiting | McMaster University | 40 | 2023-09-01 | 2023-08-07 |
| Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies Sodium Thiosulfate, 5-Fluorouracil, Oxaliplatin - Peritoneal Mesothelioma, Peritoneal Carcinomatosis | Phase 1 | Recruiting | National Cancer Institute (NCI) | 60 | 2021-10-19 | 2026-11-09 |
| Comparison Between Topical Mitomycin C and Cyclosporine Mitomycin c - Pterygium | Phase 1 | Completed | Egymedicalpedia | 57 | 2021-01-01 | 2023-10-17 |
| PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer Biopsy, Cisplatin, Doxorubicin - Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IVA Gastric Cancer AJCC v8 | Phase 1 | Recruiting | City of Hope Medical Center | 49 | 2020-08-21 | 2026-08-26 |
| Chemoembolization for Lung Tumors Chemoembolization, Mitomycin C, Lipiodol - Lung Metastases, Endobronchial Metastases | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 10 | 2019-12-13 | 2025-05-16 |
| Decorin in Sub Scleral Trabeculectomy Decorin, Mitomycin c - Primary Open-angle Glaucoma | Phase 1 | Unknown | Cairo University | 52 | 2019-09-01 | 2019-04-23 |
| Study of Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology Dexamethasone, Diphenhydramine, Famotidine - Diseases of Oesophagus Stomach and Duodenum | Phase 1 | Completed | M.D. Anderson Cancer Center | 29 | 2017-10-27 | 2023-04-21 |
| CAVATAK (CVA21) in Non-muscle Invasive Bladder Cancer (VLA-012 CANON) CVA21, Mitomycin C - Non-muscle Invasive Bladder Cancer | Phase 1 | Completed | Viralytics | 16 | 2015-01-16 | 2022-07-27 |
| Phase I Study of Cetuximab in Combination With 5-fluoruracil, Mitomycin C and Radiotherapy in Patients With Anal Cancer Stage T2 (>4 cm) - T4 N0-3 M0 or Any T N2-3 M0 Cetuximab, Mitomycin C, 5-Fluoruracil - Locally Advanced Cancer in the Anal Region | Phase 1 | Completed | Lund University Hospital | 21 | 2012-06-01 | 2020-02-28 |
| Phase I Mitomycin Combined With Bacillus Calmette-Guérin (BCG) for Bladder Cancer Mitomycin C - Urinary Bladder Neoplasm | Phase 1 | Completed | The University of Texas Health Science Center at San Antonio | 18 | 2012-03-01 | 2015-12-03 |
| Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors Laboratory Biomarker Analysis, Mitomycin, Veliparib - Solid Neoplasm | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-10-01 | 2016-07-11 |
| Sorafenib Tosylate and Chemoembolization in Treating Patients With Unresectable Liver Cancer sorafenib tosylate, doxorubicin hydrochloride, cisplatin - Hepatocellular Carcinoma, Liver Cancer | Phase 1 | Completed | Abramson Cancer Center at Penn Medicine | 18 | 2009-09-01 | 2013-02-26 |
| Sorafenib Tosylate and Chemoembolization With Doxorubicin Hydrochloride and Mitomycin in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery doxorubicin hydrochloride, mitomycin C, sorafenib tosylate - Liver Cancer | Phase 1 | Completed | UNC Lineberger Comprehensive Cancer Center | 11 | 2009-07-22 | 2018-01-05 |
| Use of Ranibizumab With Mitomycin C During Trabeculectomy Ranibizumab, Ranibizumab and MMC, MMC - Glaucoma | Phase 1 / Phase 2 | Completed | University of Colorado, Denver | 30 | 2008-04-01 | 2016-10-13 |
| Safety Study of Recombinant Human Hyaluronidase (Chemophase) in Combination With Mitomycin in Participants With Superficial Bladder Cancer Mitomycin C, Chemophase - Bladder Cancer | Phase 1 / Phase 2 | Completed | Halozyme Therapeutics | 27 | 2006-03-30 | 2021-10-29 |
| Study With Mitomycin c/5-FU/FA in Pretreated Gastrointestinal Cancer Patients With Metastases (>= Second-line Treatment) Mitomycin C, 5-FU, Folinic acid - Gastrointestinal Neoplasms, Neoplasm Metastasis | Phase 1 / Phase 2 | Completed | University Hospital Tuebingen | 1999-09-01 | 2013-01-28 | |
| Irinotecan Plus Mitomycin in Treating Patients With Advanced Solid Tumors irinotecan hydrochloride, mitomycin C - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | The University of Texas Health Science Center at San Antonio | 12 | 1998-08-01 | 2012-08-09 |
| Mitomycin and Mitoxantrone in Treating Patients With Acute Myelogenous Leukemia sargramostim, mitomycin C, mitoxantrone hydrochloride - Leukemia | Phase 1 | Completed | Dartmouth-Hitchcock Medical Center | 29 | 1996-09-01 | 2018-03-19 |
Urinary Bladder Neoplasms (4) · Non-Muscle Invasive Bladder Neoplasms (3) · Appendiceal Neoplasms (2) · Carcinoma, Hepatocellular (2) · Colorectal Neoplasms (2) · Gastrointestinal Neoplasms (2) · Liver Neoplasms (2) · Neoplasm Metastasis (2) · Ovarian Neoplasms (2) · Peritoneal Neoplasms (2) · Stomach Neoplasms (2) · Anus Neoplasms (1) · Glaucoma (1) · Glaucoma, Open-Angle (1) · Leukemia (1)
National Cancer Institute (NCI) (2) · The University of Texas Health Science Center at San Antonio (2) · Abramson Cancer Center at Penn Medicine (1) · Cairo University (1) · City of Hope Medical Center (1) · Dartmouth-Hitchcock Medical Center (1) · Egymedicalpedia (1) · Halozyme Therapeutics (1) · Lund University Hospital (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · McMaster University (1) · Memorial Sloan Kettering Cancer Center (1) · UNC Lineberger Comprehensive Cancer Center (1) · University Hospital Tuebingen (1)
United States (13) · Egypt (2) · Norway (1) · Sweden (1) · United Kingdom (1)
Anders Johnsson, MD, PhD (1) · Andrew M Blakely, M.D. (1) · Brian D. Badgwell, MD (1) · Carsten Bokemeyer, MD (1) · Christopher H. Lowrey, MD (1) · Hanna H. Sanoff, MD (1) · Hardev Pandha (1) · Joerg T Hartmann, MD (1) · Malik Y. Kahook, MD (1) · Marwa Zaki, Assist.Prof. (1) · Michael Soulen (1) · Mustafa Raoof, MD (1) · Robert S. Svatek, MD, MSCI (1) · Ronald L. Drengler, MD (1) · Sameh Mikhail (1)
PMID 20570237, PMID 26597443, PMID 31273010
2014 (1), N01CM00070 (1), N01CM62207 (1), P30CA016058 (1), P30CA016086 (1), P30CA023108 (1), P30CA033572 (1), P30CA054174 (1), UL1TR002377 (1)