57 completed, 23 unknown, 16 terminated, 15 recruiting. 54 Phase 2, 40 Phase 3, 19 Phase 1, 10 Phase 4, 4 Not applicable.
Follow Mitomycin C: new trials by email Literature Review of Mitomycin C trials Research Report on Mitomycin C
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Appendix Carcinoma, Metastatic Colorectal Carcinoma | Phase 3 | Recruiting | City of Hope Medical Center | 129 | 2026-10-01 | 2026-09-25 |
| Combined Systemic and Intraperitoneal Chemotherapy for Synchronous Gastric and/or Gastroesophageal Peritoneal Carcinomatosis Cisplatin, Mitomycin C - Synchronous Gastric Peritoneal Carcinomatosis, Gastroesophageal Peritoneal Carcinomatosis | Phase 2 | Recruiting | Mohammad Haroon Asif Choudry | 22 | 2026-09-29 | 2026-10-22 |
| Active Surveillance Versus Adjuvant Intravesical Chemotherapy in Liquid Biopsy-Defined Low-Shedding Intermediate-Risk NMIBC Active Surveillance, Adjuvant Intravesical Chemotherapy - Bladder Cancer, Non-Muscle-Invasive Bladder Cancer (NMIBC) | Not applicable | Recruiting | Tianjin Medical University Second Hospital | 670 | 2026-08-10 | 2026-10-09 |
| Metronomic Gemcitabine, Mitomycin C, and Thalidomide for Advanced Solid Tumors Gemcitabine, Mitomycin C, Thalidomide - Solid Tumor Cancer | Phase 2 | Recruiting | Sarcoma Oncology Research Center, LLC | 60 | 2026-06-01 | 2026-06-26 |
| Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309) Enfortumab vedotin, Conventional Radiotherapy, Hypofractionated Radiotherapy - Urothelial Cancer, Urinary Bladder Neoplasms | Phase 3 | Recruiting | Astellas Pharma Global Development, Inc. | 390 | 2026-05-11 | 2026-10-28 |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study Biospecimen Collection, Cisplatin, Computed Tomography - Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 486 | 2025-10-07 | 2026-10-23 |
| A Study to Evaluate TAR-210 Versus Intravesical Chemotherapy Treatment in Participants With High Risk Non-Muscle-Invasive Bladder Cancer TAR-210, Mitomycin C, Gemcitabine - Non-Muscle Invasive Bladder Neoplasms | Phase 3 | Recruiting | Janssen Research & Development, LLC | 220 | 2025-09-10 | 2026-09-28 |
| Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial Biospecimen Collection, Cisplatin, Computed Tomography - Non-Muscle Invasive Bladder Urothelial Carcinoma, Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 160 | 2025-06-03 | 2026-10-19 |
| Chemoablation Or Bladder Resection With Adjuvant Chemotherapy in Recurrent Non-Muscle Invasive Bladder Cancer Mitomycin c - Non-Muscle Invasive Bladder Cancer | Phase 4 | Recruiting | Jakob Kristian Jakobsen | 272 | 2025-06-01 | 2025-10-03 |
| In-home Intravesical Chemotherapy for the Treatment of Bladder Cancer, INVITE Trial BCG Solution, Cystoscopy, Docetaxel - Non-Muscle Invasive Bladder Carcinoma, Stage 0a Bladder Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 40 | 2025-04-21 | 2026-10-08 |
| Study to Evaluate the Non-inferiority of Low-dose HIPEC Versus High-dose HIPEC in the Treatment of PMP (HIPEC-PMP) Mitomycin c - Pseudomyxoma Peritonei | Phase 3 | Recruiting | University of Southampton | 176 | 2024-12-04 | 2026-02-19 |
| Effect of Mitomycin-C on the Outcomes of Patients Receiving Ahmed Glaucoma Valve Implantation Surgery Mitomycin c - Glaucoma | Phase 3 | Not yet recruiting | St. Joseph's Healthcare Hamilton | 144 | 2024-12-01 | 2024-11-08 |
| A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG) TAR-200, Mitomycin C, Gemcitabine - Non-Muscle Invasive Bladder Neoplasms | Phase 3 | Active not recruiting | Janssen Research & Development, LLC | 272 | 2024-04-09 | 2026-09-25 |
| Intravesical Mitomycin C After Diagnostic Ureteroscopy for Upper Tract Urothelial Carcinoma Mitomycin C - Urothelial Carcinoma Ureter, Urothelial Cancer of Renal Pelvis | Phase 1 | Not yet recruiting | McMaster University | 40 | 2023-09-01 | 2023-08-07 |
| REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity Mitigation Radiation (reduced elective nodal dose (30.6 Gy), Capecitabine, Mitomycin c - Anal Cancer | Phase 2 / Phase 3 | Active not recruiting | University of Cincinnati | 33 | 2023-08-14 | 2025-12-18 |
| Phase II Trial of Lung Chemoemobolization Computed Tomography, Ethiodized Oil, Mitomycin - Lung Non-Small Cell Carcinoma, Mediastinal Neoplasm | Phase 2 | Recruiting | City of Hope Medical Center | 30 | 2023-05-12 | 2026-03-05 |
| Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer Anoscopy, Biospecimen Collection, Capecitabine - AIDS-Related Anal Carcinoma, Anal Margin Squamous Cell Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 40 | 2022-08-09 | 2026-10-05 |
| Safety and Feasibility of HIPEC for High-Risk Gallbladder Adenocarcinoma HIPEC - Gallbladder Adenocarcinoma | Early Phase 1 | Recruiting | West Virginia University | 10 | 2022-06-23 | 2026-04-20 |
| Intralesional Injection of Mitomycin C Following Visual Internal Urethrotomy for Recurrent Urethral Stricture Mitomycin c - Urethral Stricture | Phase 2 / Phase 3 | Completed | Ain Shams University | 50 | 2022-01-01 | 2024-01-30 |
| Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies Sodium Thiosulfate, 5-Fluorouracil, Oxaliplatin - Peritoneal Mesothelioma, Peritoneal Carcinomatosis | Phase 1 | Recruiting | National Cancer Institute (NCI) | 60 | 2021-10-19 | 2026-10-29 |
Showing 20 of 122. Sign in to see all of them.
Urinary Bladder Neoplasms (22) · Non-Muscle Invasive Bladder Neoplasms (12) · Anus Neoplasms (11) · Colorectal Neoplasms (11) · Glaucoma (10) · Appendiceal Neoplasms (8) · Carcinoma, Non-Small-Cell Lung (7) · Neoplasm Metastasis (7) · Colonic Neoplasms (6) · Stomach Neoplasms (6) · Lung Neoplasms (5) · Neoplasms (5) · Peritoneal Neoplasms (5) · Rectal Neoplasms (5) · Anal Canal Carcinoma (4)
National Cancer Institute (NCI) (9) · European Organisation for Research and Treatment of Cancer - EORTC (4) · City of Hope Medical Center (3) · M.D. Anderson Cancer Center (3) · Mayo Clinic (3) · Medical Research Council (3) · Fox Chase Cancer Center (2) · Gynecologic Oncology Group (2) · Janssen Research & Development, LLC (2) · Pro Top & Mediking Company Limited (2) · Radiation Therapy Oncology Group (2) · The University of Texas Health Science Center at San Antonio (2) · UNICANCER (2) · University Hospital Birmingham (2) · Abnoba Gmbh (1)
United States (68) · United Kingdom (20) · Germany (7) · Belgium (6) · Canada (6) · China (6) · France (6) · Italy (6) · Egypt (5) · Netherlands (5) · Brazil (3) · Denmark (3) · Israel (3) · Norway (3) · South Korea (3)
Brian D. Badgwell, MD (2) · Dominique Elias, MD (2) · Ian E. Smith, MD (2) · Martin F. Muers, MD (2) · Parminder Singh (2) · Adrian Hodson (1) · Al B Benson (1) · Al B. Benson, MD, FACP (1) · Albert Koong (1) · Aldo V. Bono, MD (1) · Alex W Yeung, MBBS (1) · Alexander Stojadinovic, MD (1) · Alvarado Beatriz, M.D. (1) · Anders Johnsson, MD, PhD (1) · Andrew M Blakely, M.D. (1)
PMID 34125951, PMID 36912740, PMID 10937547, PMID 12051882, PMID 16051328, PMID 16157935, PMID 17122118, PMID 17470859, PMID 17544497, PMID 18430910, PMID 18486741, PMID 19139424, PMID 19643599, PMID 20354452, PMID 20564111, PMID 20570237, PMID 21135251, PMID 21156335, PMID 22512481, PMID 23150707, PMID 24490762, PMID 26597443, PMID 28643069, PMID 29477688, PMID 30274699, PMID 30390114, PMID 31273010, PMID 31727428, PMID 31785830, PMID 32067679, PMID 32124514, PMID 32556731, PMID 32622848, PMID 33539743, PMID 33660142, PMID 36223555, PMID 37012180, PMID 37611799, PMID 39680823, PMID 41074972
P30CA033572 (3), U10CA180820 (3), 2023 (2), U10CA180868 (2), 2014 (1), N01CM00070 (1), N01CM62207 (1), P30CA006973 (1), P30CA015083 (1), P30CA016058 (1), P30CA016086 (1), P30CA023108 (1), P30CA054174 (1), U01CA079778 (1), U01CA080098 (1)