14 completed, 3 unknown, 2 active not recruiting, 2 recruiting. 9 Phase 1, 8 Phase 2, 3 Phase 3, 2 Phase 4, 1 Early Phase 1.
Follow Midazolam Hydrochloride: new trials by email Literature Review of Midazolam Hydrochloride trials Research Report on Midazolam Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
| Ketamine for Combined Depression and Alcohol Use Disorder Ketamine Hydrochloride, Midazolam Hydrochloride - Depression, Alcohol Use Disorder | Phase 1 / Phase 2 | Recruiting | University Hospital of North Norway | 34 | 2025-01-20 | 2026-06-23 |
| Ketamine for Methamphetamine Use Disorder Ketamine Hydrochloride, Midazolam Hydrochloride - Substance Use Disorders, Substance Use | Phase 2 | Completed | University of Texas Southwestern Medical Center | 120 | 2024-09-11 | 2026-10-27 |
| Predictors of Intravenous Ketamine Response in TRD Ketamine, Midazolam - Treatment Resistant Depression, Major Depressive Disorder | Phase 3 | Active not recruiting | Abraham Nunes | 40 | 2024-01-19 | 2026-05-22 |
| i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial Ketamine hydrochloride, i-CBT (Internet-based Cognitive Behavioural Therapy), Midazolam Hydrochloride - Major Depressive Disorder, Suicide | Phase 2 | Active not recruiting | University Health Network, Toronto | 76 | 2024-01-02 | 2026-10-06 |
| Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis Caffeine, Metoprolol, Midazolam - Atopic Dermatitis | Early Phase 1 | Completed | Amgen | 21 | 2023-06-03 | 2025-12-23 |
| Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents Ketamine Hydrochloride, Midazolam Hydrochloride - Suicide, Attempted, Suicide and Depression | Phase 3 | Completed | University of Texas Southwestern Medical Center | 50 | 2022-10-03 | 2026-10-15 |
| Ketamine for Treatment-Resistant Bipolar Disorder Ketamine Hydrochloride, Midazolam Hydrochloride - Bipolar Disorder, Bipolar Depression | Phase 2 | Completed | Joshua Rosenblat | 71 | 2022-07-04 | 2026-03-05 |
| Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4 Tralokinumab, Caffeine, Warfarin - Atopic Dermatitis | Phase 1 | Completed | LEO Pharma | 40 | 2018-08-13 | 2025-02-24 |
| Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s Midazolam hydrochloride, Metoprolol tartrate, Pioglitazone hydrochloride - Healthy | Phase 1 | Completed | Corcept Therapeutics | 27 | 2018-03-06 | 2018-05-17 |
| Evaluate the Effect of Entrectinib on the Pharmacokinetics of Midazolam in Cancer Patients Entrectinib, Midazolam Hydrochloride - Advanced Solid Tumor | Phase 1 | Completed | Hoffmann-La Roche | 15 | 2017-11-14 | 2018-08-21 |
| Investigation of Antidepressant Efficacy of Oral Ketamine Treatment Ketamine, Midazolam Hydrochloride - Major Depressive Episode | Phase 2 | Unknown | Medical University of Vienna | 60 | 2017-04-24 | 2019-09-03 |
| Safety and Efficacy of Intranasal Dexmedetomidine Dexmedetomidine, Midazolam Hydrochloride, Nitrous Oxide - Safety and Efficacy of Intranasal Dexmedetomidine | Phase 4 | Unknown | Bon Secours Pediatric Dental Associates | 100 | 2017-01-01 | 2016-12-07 |
| Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia dexter ketamine, Lidocaine Hydrochloride, Fentanyl Hydrochloride - Pain, Postoperative, Anesthesia Complication | Phase 4 | Unknown | Federal University of São Paulo | 40 | 2016-11-01 | 2016-11-04 |
| Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery Midazolam Hydrochloride, Fentanyl, Ketamine - Anesthesia, Tooth Extraction | Phase 1 | Completed | Albert Einstein College of Medicine | 73 | 2016-10-04 | 2026-03-27 |
| Understanding How Ketamine Brings About Rapid Improvement in OCD Ketamine, Midazolam - Obsessive-Compulsive Disorder | Phase 2 | Completed | Stanford University | 120 | 2016-08-16 | 2026-08-13 |
| A PHASE 1, OPEN-LABEL, CROSS-OVER, FIXED SEQUENCE STUDY TO EVALUATE THE EFFECT OF MULTIPLE DOSES OF DS-1971A ON THE SINGLE DOSE PHARMACOKINETICS OF PROBE SUBSTRATES FOR CYP2B6, CYP2C8, CYP2C9, CYP2C19 AND CYP3A4 ENZYMES IN HEALTHY MALE AND FEMALE SUBJECTS DS-1971a, midazolam hydrochloride, Omeprazole - Healthy | Phase 1 | Completed | Daiichi Sankyo | 18 | 2015-05-01 | 2015-11-05 |
| Action of Ketamine in Treatment-Resistant Depression Ketamine, Midazolam - Treatment-resistant Depression | Phase 2 / Phase 3 | Completed | University of Ottawa | 46 | 2013-05-01 | 2018-06-26 |
| Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced Solid Tumors Gamma-Secretase Inhibitor RO4929097, Ketoconazole, Rifampin - Adult Solid Neoplasm | Phase 1 | Completed | National Cancer Institute (NCI) | 17 | 2010-09-01 | 2014-12-23 |
| Study to Evaluate the Effect of Multiple Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Warfarin, Omeprazole, Caffeine, and Dextromethorphan in Healthy Male Volunteers BIRT 2584 XX, Warfarin sodium, Omeprazole - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 20 | 2005-09-01 | 2014-10-06 |
Showing 20 of 21. Sign in to see all of them.
Depressive Disorder, Treatment-Resistant (4) · Bipolar Disorder (3) · Depression (3) · Depressive Disorder, Major (3) · Dermatitis, Atopic (2) · Suicidal Ideation (2) · Suicide (2) · Alcoholism (1) · Amnesia (1) · Behavior, Addictive (1) · Borderline Personality Disorder (1) · Ileus (1) · Memory Disorders (1) · Nausea (1) · Obsessive-Compulsive Disorder (1)
Joshua Rosenblat (2) · University of Texas Southwestern Medical Center (2) · Abraham Nunes (1) · Albert Einstein College of Medicine (1) · Amgen (1) · Boehringer Ingelheim (1) · Bon Secours Pediatric Dental Associates (1) · Corcept Therapeutics (1) · Daiichi Sankyo (1) · Federal University of São Paulo (1) · Hoffmann-La Roche (1) · LEO Pharma (1) · Medical University of Vienna (1) · Memorial Sloan Kettering Cancer Center (1) · National Cancer Institute (NCI) (1)
United States (11) · Canada (5) · Austria (1) · Brazil (1) · France (1) · Netherlands (1) · Norway (1) · United Kingdom (1)
Madhukar Trivedi, MD (2) · Abraham Nunes, MD PhD MBA FRCPC (1) · Andreas W Blomkvist, M.D. (1) · Carolyn I Rodriguez, MD, PhD (1) · George Wilding (1) · Joshua D. Rosenblat, MD, MSc (1) · Joshua Rosenblat, MD, MSc (1) · Kane O. Pryor, M.D. (1) · Kirsteen Donaldson, FFPM,DM,FRCP (1) · Pierre Blier, M.D, Ph.D (1) · Rodrigo Mansur (1)
PMID 17959952, PMID 30922101, PMID 34971723, PMID 35267254, PMID 35931041, PMID 42684694, PMID 42849709
2018 (1), 2023 (1), P30CA014520 (1), R01MH125181 (1), U01CA062491 (1)