16 completed, 11 unknown, 7 terminated, 4 active not recruiting. 18 Not applicable, 14 Phase 3, 4 Phase 2, 1 Phase 1, 1 Phase 4.
Follow Microfracture: new trials by email Literature Review of Microfracture trials Research Report on Microfracture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Minced Cartilage Implantation Versus Microfracture for Acetabular Chondral Lesions Due to FAI (Femoro-acetabular Impingement) Minced cartilage implantation - MCI, Microfracture - Femoro-acetabular Impingement (FAI) | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 180 | 2026-07-01 | 2026-06-18 |
| A Study of Collagen Scaffold for the Repair of Elbow Cartilage Injury Collagen Scaffold (Colla-Plug), microfracture - Cartilage Defect, Elbow Injury | Phase 3 | Not yet recruiting | Beijing Jishuitan Hospital | 90 | 2025-08-01 | 2025-09-02 |
| Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects MegaCarti®, Microfracture - Osteoarthritis, Knee | Not applicable | Completed | L&C Bio | 61 | 2024-01-22 | 2026-02-25 |
| Clinical Trial to Evaluate the Regeneration of Articular Cartilage Through Arthroscopy After MegaCarti® Application MegaCarti®, microfracture - Osteoarthritis, Knee | Completed | L&C Bio | 40 | 2023-06-23 | 2024-10-09 | |
| The Effectiveness of the Microfracture Technique in the Meniscal Healing Microfracture - Microfractures, Meniscus Tear | Unknown | Hasanuddin University | 62 | 2023-03-31 | 2023-04-05 | |
| Chondro-Gide® Bilayer Collagen Membrane in Knee Cartilage Defect Repair Microfracture, Chondro-Gide bilayer collagen membrane - Cartilage Defects | Not applicable | Terminated | Geistlich Pharma AG | 75 | 2023-03-10 | 2026-03-09 |
| Efficacy of BST-CarGel in Treating Chondral Lesions of the Hip BST-CarGel, Microfracture - Disorder of Hip Region | Not applicable | Withdrawn | Nova Scotia Health Authority | 2022-12-01 | 2024-02-07 | |
| A Comparison of JointRep® and Microfracture in Repair of Cartilage Lesions on the Femoral Condyle or Trochlea, JointRep®, Microfracture - Chondral Defect, Articular Cartilage Defect | Not applicable | Unknown | Oligo Medic Pty Ltd | 185 | 2021-09-22 | 2024-03-20 |
| Treatment of Cartilage Defects With Peripheral Blood Stem Cells autologous peripheral blood mesenchymal stem cell, Microfracture, Microfracture + collagen membrane - Cartilage Injury | Phase 1 | Unknown | Peking University Third Hospital | 252 | 2021-08-01 | 2021-07-08 |
| Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee Microfracture, Microfracture plus placement of Chondro-Gide® ACC - Knee Injuries, Cartilage Injury | Not applicable | Terminated | Geistlich Pharma AG | 82 | 2020-08-26 | 2026-02-13 |
| Guided Cartilage Regeneration Membrane Guided cartilage regeneration membrane, Microfracture - Articular Cartilage Injury, Knee Ligament Injury | Not applicable | Unknown | Peking University Third Hospital | 150 | 2020-08-03 | 2020-07-09 |
| Episealer® Knee System IDE Clinical Study Episealer Knee System, Microfracture - Degenerative Lesion of Articular Cartilage of Knee | Not applicable | Active not recruiting | Episurf Medical Inc. | 13 | 2020-06-18 | 2026-10-14 |
| Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects MegaCarti®, Microfracture - Osteoarthritis, Knee | Not applicable | Active not recruiting | L&C Bio | 90 | 2020-04-16 | 2022-06-30 |
| Efficacy and Safety of Allogenic Stem Cell Product(CARTISTEM®) for Osteochondral Lesion of Talus CARTISTEM®, Microfracture - Chondral or Osteochondral Lesion of Talus | Phase 3 | Completed | Hyundai Bioland Co., Ltd. | 102 | 2020-03-03 | 2022-11-29 |
| Long-term Safety and Efficacy of CartiFill After Microfracture Surgery in Knee Cartilage Defects CartiFill, Microfracture - Cartilage Defects of the Knee | Completed | Cellontech Co., Ltd. | 36 | 2020-02-03 | 2026-06-02 | |
| A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee MACI, microfracture - Chondral Defect, Osteochondritis Dissecans (OCD) | Phase 3 | Recruiting | Vericel Corporation | 45 | 2018-10-24 | 2026-10-13 |
| Microfracture vs. Microfracture and BMAC for Osteochondral Lesions of the Talus Microfracture with Bone Marrow Aspirate Concentrate, Microfracture - Osteochondral Lesion of Talus | Not applicable | Unknown | Rothman Institute Orthopaedics | 70 | 2018-10-18 | 2019-02-27 |
| Clinical Study of Decalcification Bone Scaffold for Cartilage Lesions of the Knee decalcification bone scaffold, microfracture - Cartilage Injury | Not applicable | Unknown | Peking University Third Hospital | 60 | 2018-09-11 | 2020-07-02 |
| Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair Arthroscopic synovial brushing, Microfracture - Defect of Articular Cartilage, Cartilage Injury | Not applicable | Completed | University of Leeds | 4 | 2017-01-01 | 2023-11-29 |
| HyaloFAST Trial for Repair of Articular Cartilage in the Knee Hyalofast, Microfracture - Defect of Articular Cartilage | Not applicable | Active not recruiting | Anika Therapeutics, Inc. | 200 | 2015-12-01 | 2026-04-15 |
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Fractures, Stress (17) · Osteoarthritis, Knee (4) · Osteochondritis Dissecans (4) · Osteoarthritis (3) · Wounds and Injuries (3) · Knee Injuries (2) · Arthritis (1) · Cartilage Diseases (1) · Elbow Injuries (1) · Femoracetabular Impingement (1) · Joint Diseases (1)
Cellontech Co., Ltd. (3) · Geistlich Pharma AG (3) · L&C Bio (3) · Peking University Third Hospital (3) · Vericel Corporation (3) · Histogenics Corporation (2) · Aesculap Biologics, LLC (1) · Anika Therapeutics, Inc. (1) · Arthro-Anda Tianjin Biologic Technology Co., Ltd. (1) · Beijing Jishuitan Hospital (1) · Bergen Orthopedic Study Group (1) · Biosolution Co., Ltd. (1) · DePuy Mitek (1) · Episurf Medical Inc. (1) · GCS Ramsay Santé pour l'Enseignement et la Recherche (1)
United States (13) · South Korea (8) · Canada (6) · China (6) · Germany (6) · United Kingdom (5) · France (4) · Poland (4) · Czechia (3) · Netherlands (3) · Norway (3) · Austria (2) · Belgium (2) · Hungary (2) · Indonesia (2)
Fabiana Martinelli (2) · Yong In, MD (2) · Alberto Gobbi, MD (1) · Andrea Belschner (1) · Avner Yayon, PhD MD (1) · Beom-gu Lee, MD, PhD (1) · Brooks Story, PhD (1) · Bruce Caldwell, MBBS, FRACS (1) · Chan Woong Moon, MD (1) · Cheol Hong Jeon, MD (1) · Choong-hyuk Choi, MD, PhD (1) · Chul-won Ha, MD, PhD (1) · Dennis G McGonagle, MB BcH BAO (1)
PMID 18202295, PMID 19846694, PMID 23672920, PMID 23730377, PMID 24356241, PMID 24714783, PMID 25416965, PMID 27489411, PMID 28068480, PMID 28108777, PMID 31317047, PMID 31893951, PMID 32064573, PMID 32476445, PMID 33143647, PMID 33490296, PMID 33512974, PMID 38230875, PMID 38501741, PMID 38630297, PMID 39525351, PMID 40778441
2009 (2)