7 completed, 3 terminated, 1 active not recruiting, 1 not yet recruiting. 14 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Completed 7, Terminated 3, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow microfracture: new trials by email Literature Review of microfracture trials Research Report on microfracture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Collagen Scaffold for the Repair of Elbow Cartilage Injury Collagen Scaffold (Colla-Plug), microfracture - Cartilage Defect, Elbow Injury | Phase 3 | Not yet recruiting | Beijing Jishuitan Hospital | 90 | 2025-08-01 | 2025-09-02 |
| Efficacy and Safety of Allogenic Stem Cell Product(CARTISTEM®) for Osteochondral Lesion of Talus CARTISTEM®, Microfracture - Chondral or Osteochondral Lesion of Talus | Phase 3 | Completed | Hyundai Bioland Co., Ltd. | 102 | 2020-03-03 | 2022-11-29 |
| A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee MACI, microfracture - Chondral Defect, Osteochondritis Dissecans (OCD) | Phase 3 | Recruiting | Vericel Corporation | 45 | 2018-10-24 | 2026-10-13 |
| NOVOCART®3D for Treatment of Articular Cartilage of the Knee Microfracture, NOVOCART 3D - Articular Cartilage of the Femoral Condyle Between 2-6cm2 | Phase 3 | Active not recruiting | Aesculap Biologics, LLC | 233 | 2013-12-01 | 2025-03-21 |
| Phase III Study to Evaluate Safety and Effectiveness of NOVOCART 3D Plus vs. Microfracture in Knee Cartilage Defects NOVOCART® 3D plus, Microfracture - Traumatic Articular Cartilage Defects in the Knee Joint | Phase 3 | Completed | Tetec AG | 263 | 2013-05-01 | 2023-11-24 |
| Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect CARTISTEM, Microfracture - Degenerative Osteoarthritis, Defect of Articular Cartilage | Phase 3 | Completed | Medipost Co Ltd. | 103 | 2012-06-01 | 2017-04-20 |
| Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional Microfracture Microfracture, Cartilage Autograft Implantation System (CAIS) - Other Articular Cartilage Disorders, Osteochondritis Dissecans | Phase 3 | Unknown | Singapore General Hospital | 36 | 2012-01-01 | 2012-03-21 |
| Neocartilage Implant to Treat Cartilage Lesions of the Knee Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture - Articular Cartilage Disorder, Degeneration; Articular Cartilage | Phase 3 | Terminated | ISTO Technologies, Inc. | 14 | 2011-07-01 | 2017-08-31 |
| Efficacy and Safety Study of co.Don Chondrosphere to Treat Cartilage Defects co.don chondrosphere®, Microfracture - Articular Cartilage Lesion of the Femoral Condyle | Phase 3 | Completed | co.don AG | 102 | 2010-10-01 | 2021-01-27 |
| Confirmatory Study of NeoCart in Knee Cartilage Repair NeoCart, Microfracture - Articular Cartilage Defects in the Knee Joint | Phase 3 | Terminated | Histogenics Corporation | 245 | 2010-05-01 | 2019-03-29 |
| Comparison of Microfracture Treatment and CARTIPATCH® Chondrocyte Graft Treatment in Femoral Condyle Lesions CARTIPATCH® procedure, Microfracture - Knee Chondral, Osteochondral Defect | Phase 3 | Terminated | TBF Genie Tissulaire | 40 | 2008-10-01 | 2015-04-28 |
| Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee autologous cultured chondrocytes on porcine collagen membrane, Microfracture - Articular Cartilage Defect | Phase 3 | Completed | Vericel Corporation | 144 | 2008-07-01 | 2021-05-12 |
| A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects. Microfracture, Chondro-Gide sutured, Chondro-Gide glued - Cartilage Injury, Osteochondritis Dissecans | Phase 3 | Completed | Geistlich Pharma AG | 67 | 2003-12-01 | 2017-02-23 |
| RCT of ChondroCelect® (in an ACI Procedure) vs Microfracture in the Repair of Cartilage Defects of the Knee ChondroCelect implantation, Microfracture - Articular Cartilage Lesion of the Femoral Condyle | Phase 3 | Completed | TiGenix n.v. | 118 | 2002-02-01 | 2011-09-26 |
Osteochondritis Dissecans (3) · Fractures, Stress (2) · Elbow Injuries (1) · Joint Diseases (1) · Osteoarthritis (1)
Vericel Corporation (2) · Aesculap Biologics, LLC (1) · Beijing Jishuitan Hospital (1) · Geistlich Pharma AG (1) · Histogenics Corporation (1) · Hyundai Bioland Co., Ltd. (1) · ISTO Technologies, Inc. (1) · Medipost Co Ltd. (1) · Singapore General Hospital (1) · TBF Genie Tissulaire (1) · Tetec AG (1) · TiGenix n.v. (1) · co.don AG (1)
Germany (4) · United States (4) · Poland (3) · Belgium (2) · Canada (2) · Czechia (2) · France (2) · Netherlands (2) · South Korea (2) · United Kingdom (2) · Austria (1) · China (1) · Croatia (1) · Hungary (1) · Latvia (1)
Andrea Belschner (1) · Beom-gu Lee, MD, PhD (1) · Choong-hyuk Choi, MD, PhD (1) · Chul-won Ha, MD, PhD (1) · Frank P Luyten, M.D., Ph.D. (1) · Hong-chul Lim, MD, PhD (1) · Hwa-jae Jeong, MD, PhD (1) · Jae-doo Yoo, MD, PhD (1) · Johan Vanlauwe, M.D. (1) · Jonathan Hopper, BSc (Hons), MB ChB, FRCSEd (1) · Jong-hyeok Choi, MD, PhD (1) · Jung-ro Yoon, MD, PhD (1) · Michaela Purcell (1)
PMID 18202295, PMID 19846694, PMID 23672920, PMID 23730377, PMID 24356241, PMID 24714783, PMID 27489411, PMID 28108777, PMID 31317047, PMID 31893951, PMID 32064573, PMID 33490296, PMID 38501741, PMID 38630297, PMID 40778441
2009 (1)