45 completed, 13 unknown, 9 active not recruiting, 6 recruiting. 77 Phase 3, 8 Phase 2.
Follow Mercaptopurine: new trials by email Literature Review of Mercaptopurine trials Research Report on Mercaptopurine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | Children's Oncology Group | 1708 | 2026-08-28 | 2026-07-30 |
| Capizzi Escalating Methotrexate Versus High Dose Methotrexate in Children With Newly Diagnosed T-cell Lymphoblastic Lymphoma (T-LBL) Prednisone,Vincristine, Pegylated-asparaginase, Bortezomib,Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine, methotrexate, Dexamethasone, Doxorubicin, Prednisone,Vincristine, Pegylated-asparaginase, Bortezomib,Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine, methotrexate, Dexamethasone, Doxorubicin, Vindesine, Etoposide, Ifosfamide - T-cell Lymphoblastic Lymphoma | Phase 3 | Recruiting | Children's Cancer Group, China | 200 | 2023-02-06 | 2026-03-19 |
| InDuctIon TREatment with SubCuTaneous Infliximab for Crohn's Disease Infliximab subcutaneous, Immunosuppressive Agents - Inflammatory Disease, Disease Crohn | Phase 3 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 158 | 2021-11-25 | 2024-12-10 |
| The Individualized Treatment of 6-mercaptopurine in Children With Acute Lymphoblastic Leukemia in China 6-mercaptopurine, Standard treatment, Individualized treatment - Acute Lymphoblastic Leukemia, Pediatric | Phase 2 / Phase 3 | Unknown | Wei Zhao | 82 | 2020-02-01 | 2020-01-14 |
| Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration - B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma | Phase 3 | Recruiting | Children's Oncology Group | 5951 | 2019-10-31 | 2026-08-25 |
| International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma Cyclophosphamide, Cytarabine, Dexamethasone - Lymphoblastic Lymphoma, Childhood | Phase 3 | Recruiting | University Hospital Muenster | 683 | 2019-08-23 | 2026-05-06 |
| A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia Asparaginase Erwinia chrysanthemi, Blinatumomab, Cyclophosphamide - B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 6720 | 2019-07-03 | 2026-11-02 |
| Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017 Blinatumomab, Bortezomib, Cyclophosphamide - Acute Lymphoblastic Leukemia, Pediatric | Phase 3 | Recruiting | Martin Schrappe | 5000 | 2018-07-15 | 2025-04-06 |
| Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia Allopurinol, Cytarabine, Daunorubicin Hydrochloride - B Acute Lymphoblastic Leukemia | Phase 3 | Recruiting | Alliance for Clinical Trials in Oncology | 303 | 2017-09-20 | 2026-11-03 |
| Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Calaspargase Pegol, Cyclophosphamide - Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia | Phase 3 | Active not recruiting | Children's Oncology Group | 352 | 2017-08-08 | 2026-10-05 |
| Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Prednisone, Vincristine, Daunorubicin - Acute Lymphoblastic Leukemia, Acute Lymphoblastic Lymphoma | Phase 2 / Phase 3 | Active not recruiting | St. Jude Children's Research Hospital | 790 | 2017-03-29 | 2026-06-17 |
| Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Pegaspargase, Erwinia asparaginase, Cyclophosphamide - Acute Lymphoblastic Leukemia, Pediatric | Phase 3 | Active not recruiting | Dana-Farber Cancer Institute | 560 | 2017-03-03 | 2026-07-16 |
| LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis Prednisone, Vinblastine, mercaptopurine - Langerhans Cell Histiocytosis | Phase 2 / Phase 3 | Active not recruiting | North American Consortium for Histiocytosis | 1400 | 2016-11-02 | 2026-04-09 |
| Mercaptopurine Therapy in Ulcerative Colitis Mercaptopurine (Purinethol), Placebo, Mesalamine - Colitis, Ulcerative | Phase 3 | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 136 | 2016-11-01 | 2020-01-07 |
| Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment Rituximab, Nelarabine, PEG-Asparaginase - Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma | Phase 3 | Completed | Goethe University | 1023 | 2016-08-01 | 2025-12-16 |
| Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia Arsenic trioxide, Idarubicin, Cytarabine - Acute Promyelocytic Leukemia | Phase 3 | Completed | Technische Universität Dresden | 133 | 2016-06-01 | 2026-05-29 |
| A Phase III Randomized Trial of the Reduction of Chemotherapy in Philadelphia Chromosome-positive ALL of Young Adults Nilotinib, Methotrexate, Aracytine (Ara C) - Philadelphia Chromosome Positive Adult Acute Lymphoblastic Leukemia | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 265 | 2016-04-01 | 2019-10-21 |
| Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL Dexamethasone, vincristine, Cyclophosphamide - Leukemia, Leukemia, Acute | Phase 2 / Phase 3 | Unknown | Nanfang Hospital, Southern Medical University | 80 | 2016-02-14 | 2018-06-21 |
| Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL Chidamide, Dexamethasone, vincristine - Leukemia, Acute, Leukemia, T Cell | Phase 2 / Phase 3 | Unknown | Nanfang Hospital, Southern Medical University | 70 | 2016-02-14 | 2018-06-12 |
| LBL-2016 for Children or Adolescents in China Prednisone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine, 6-mercaptopurine,Methotrexate, Dexamethasone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Doxorubicin, 6-mercaptopurine - Lymphoblastic Lymphoma | Phase 3 | Active not recruiting | Children's Cancer Group, China | 150 | 2016-01-01 | 2026-03-18 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (38) · Leukemia (32) · Lymphoma (12) · Burkitt Lymphoma (9) · Leukemia, Promyelocytic, Acute (5) · Leukemia, Biphenotypic, Acute (4) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (4) · Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (3) · Crohn Disease (2) · Dendritic Cell Sarcoma, Interdigitating (2) · Down Syndrome (2) · Leukemia, Myeloid, Acute (2) · Leukemia, T-Cell (2) · Blast Crisis (1) · Cardiotoxicity (1)
Children's Oncology Group (21) · National Cancer Institute (NCI) (9) · St. Jude Children's Research Hospital (6) · European Organisation for Research and Treatment of Cancer - EORTC (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Children's Cancer Group, China (2) · Dana-Farber Cancer Institute (2) · Nanfang Hospital, Southern Medical University (2) · University Hospital Schleswig-Holstein (2) · Alliance for Clinical Trials in Oncology (1) · Assistance Publique - Hôpitaux de Paris (1) · Associazione Italiana Ematologia Oncologia Pediatrica (1) · Children's Cancer and Leukaemia Group (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dutch Childhood Oncology Group (1)
United States (43) · Canada (25) · Australia (23) · Switzerland (17) · Puerto Rico (15) · Germany (14) · New Zealand (13) · Netherlands (10) · France (9) · Italy (9) · Austria (8) · China (8) · Czechia (8) · Belgium (6) · Israel (6)
Anne L Angiolillo (2) · Sima Jeha, MD (2) · Alfred Reiter, MD (1) · Andrea Biondi (1) · Antony H. Goldstone, FRCP (1) · Barbara L. Asselin, MD (1) · Bayard Powell (1) · Birgit Burkhardt, Prof. Dr. Dr. (1) · C. Mitchell (1) · Carlos Rodriguez-Galindo, MD (1) · Charlotte Niemeyer, MD (1) · Chi-Kong Li, MD (1) · Ching-Hon Pui, M.D. (1) · Ching-Hon Pui, MD (1) · Christophe Bergeron (1)
PMID 39121442, PMID 37890117, PMID 23007406, PMID 24970932, PMID 33242441, PMID 38446568, PMID 41671463, PMID 16421426, PMID 19433688, PMID 19546402, PMID 20154213, PMID 21719599, PMID 23233662, PMID 24344215, PMID 26590194, PMID 26888258, PMID 26913693, PMID 29148893, PMID 29284596, PMID 30138085, PMID 31188727, PMID 31601692, PMID 31612640, PMID 32552472, PMID 32589970, PMID 33152759, PMID 35271306, PMID 36603187, PMID 37021527, PMID 39316653, PMID 40315406, PMID 40908865, PMID 42085640, PMID 10627444, PMID 12111109, PMID 12153596, PMID 12239143, PMID 12694250, PMID 12780755, PMID 15087948, PMID 15154634, PMID 15353542, PMID 15368546, PMID 15637138, PMID 15659500, PMID 15801953, PMID 15952999, PMID 16105981, PMID 16556888, PMID 16609069
U10CA098543 (14), U10CA180886 (10), 2017 (2), F32CA141762 (2), R37CA036401 (2), 2009 (1), P01CA068484 (1), P30CA006516 (1), P30CA008748 (1), P30CA021765 (1), P50GM115279 (1), R01CA090246 (1), R01CA113482 (1), R01CA140729 (1), R01CA174683 (1)