5 active not recruiting, 5 completed, 5 unknown, 2 not yet recruiting. 20 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 20 | Active not recruiting 5, Completed 5, Unknown 5, Not yet recruiting 2, Recruiting 2, Enrolling by invitation 1 |
Follow mepolizumab: new trials by email Literature Review of mepolizumab trials Research Report on mepolizumab
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab Mepolizumab 100 MG Injection - COPD (Chronic Obstructive Pulmonary Disease) | Phase 4 | Not yet recruiting | Western University, Canada | 36 | 2026-10-01 | 2026-08-06 |
| Beyond EOsinophils: proteoMICS to Identify Potential Biomarker of Organ Damage and Response to MEPOLIZUMAB in EGPA Mepolizumab 100 MG Injection [Nucala], Mepolizumab 300 mg - EGPA - Eosinophilic Granulomatosis With Polyangiitis, Severe Asthma | Phase 4 | Enrolling by invitation | Azienda Ospedaliero Universitaria di Cagliari | 90 | 2025-10-17 | 2026-01-15 |
| Anti-IL-5 Therapy With Simple Polypectomy Versus Extended Endoscopic Sinus Surgery for CRSwNP Mepolizumab, Simple Polypectomy, Extended Endoscopic Sinus Surgery - Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) | Phase 4 | Not yet recruiting | Eye & ENT Hospital of Fudan University | 360 | 2025-10-08 | 2025-10-01 |
| Complete Remission After Treatment With Biologics for Nasal Polyps DUPIXENT®, NUCALA®, Dupi discontinuation - Nasal Polyps | Phase 4 | Recruiting | Copenhagen University Hospital, Rigshospitalet | 66 | 2025-04-03 | 2025-12-05 |
| Mepolizumab and in Office-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS). surgical arm, Mepolizumab 100 MG, combined arm - Chronic Rhinosinusitis With Nasal Polyps | Phase 4 | Recruiting | Instituto de Investigación Marqués de Valdecilla | 75 | 2024-12-31 | 2026-09-11 |
| th2 Modulation CRSwNP Mepolizumab - Chronic Rhinosinusitis With Nasal Polyps | Phase 4 | Unknown | St. Paul's Sinus Centre | 40 | 2024-06-01 | 2024-04-17 |
| REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study Mepolizumab, Spirometry - Asthma | Phase 4 | Active not recruiting | GlaxoSmithKline | 336 | 2024-03-20 | 2025-08-01 |
| Identifying Predictors Of Response To Mepolizumab In CRSwNP Mepolizumab 100 MG Injection - Chronic Rhinosinusitis With Nasal Polyps | Phase 4 | Active not recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 36 | 2023-10-03 | 2026-08-31 |
| Mepolizumab and In-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS). A Three Arm Study. Mepolizumab, Polypeptomy - Rhinosinusitis Chronic, Polyp, Nasal | Phase 4 | Unknown | Instituto de Investigación Marqués de Valdecilla | 75 | 2023-09-01 | 2023-06-28 |
| Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment Mepolizumab, Placebo - Chronic Rhinosinusitis With Nasal Polyps, Asthma | Phase 4 | Unknown | St. Paul's Sinus Centre | 90 | 2023-07-01 | 2024-04-17 |
| A Real-world, Head-to-head Comparison of Dupilumab Versus Mepolizumab in Danish Patients With Chronic Rhinosinusitis With Nasal Polyps dupilumab, mepolizumab - Chronic Rhinosinusitis With Nasal Polyps, Asthma; Eosinophilic | Phase 4 | Active not recruiting | Copenhagen University Hospital, Rigshospitalet | 220 | 2023-04-27 | 2025-07-01 |
| Mepolizumab to CRSwNP Through 12 Months - Randomised to FESS and Non-FESS Within the First 2 Weeks Mepolizumab Injection, Functional Endoscopic Sinus Surgery (FESS). - Chronic Rhinosinusitis with Nasal Polyps, Asthma | Phase 4 | Active not recruiting | Vibeke Backer | 58 | 2023-04-01 | 2025-03-30 |
| Symptoms Control and adhErenCe Assessment During Treatment With MepolizUmab New pREfilled Devices Pre-filled syringe, mepolizumab 100 mg/month, Auto-injector pen, mepolizumab 100 mg/month - Asthma | Phase 4 | Active not recruiting | Hospices Civils de Lyon | 20 | 2023-03-09 | 2024-11-18 |
| Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases Mepolizumab, Normal Saline - Chronic Cough, Eosinophilic Bronchitis | Phase 4 | Completed | McMaster University | 46 | 2021-12-14 | 2025-09-16 |
| Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab) Mepolizumab, Placebo - Asthma, Aspirin-Induced, Chronic Rhinosinusitis With Nasal Polyps | Phase 4 | Completed | Helsinki University Central Hospital | 95 | 2021-08-12 | 2026-03-24 |
| Efficacy and Safety Study of Mepolizumab 100 Milligram (mg) Subcutaneous (SC) in Indian Participants Aged Greater Than or Equal to (>=) 18 Years With Severe Eosinophilic Asthma Mepolizumab, Salbutamol - Asthma | Phase 4 | Completed | GlaxoSmithKline | 100 | 2021-06-29 | 2024-12-10 |
| A Pragmatic Study to Investigate the Efficacy and Safety of Mepolizumab in Severe Uncontrolled Asthma in Brazil Mepolizumab 100 MG [Nucala] - Eosinophilic Asthma | Phase 4 | Unknown | University of Sao Paulo General Hospital | 18 | 2020-01-09 | 2020-01-14 |
| Comparing Treatment Efficacy With Mepolizumab and Omalizumab in Severe Asthma - "Choosebetweenamab". Mepolizumab, Omalizumab - Asthma, Eosinophilic Asthma | Phase 4 | Unknown | University of Newcastle, Australia | 200 | 2018-11-03 | 2020-10-14 |
| Effect of Anti-interleukin 5 (IL5) Therapy on Sputum Cells and Cytokines Mepolizumab Injection [Nucala] - Asthma | Phase 4 | Completed | KU Leuven | 22 | 2016-09-01 | 2020-06-02 |
| Omalizumab to Mepolizumab Switch Study in Severe Eosinophilic Asthma Patients Mepolizumab 100mg SC, Albuterol/salbutamol MDIs, Omalizumab - Asthma | Phase 4 | Completed | GlaxoSmithKline | 145 | 2016-03-17 | 2019-08-19 |
Asthma (11) · Pulmonary Eosinophilia (6) · Nasal Polyps (3) · Asthma, Aspirin-Induced (1) · Chronic Cough (1) · Churg-Strauss Syndrome (1) · Eosinophilia (1) · Pulmonary Disease, Chronic Obstructive (1) · Recurrence (1) · Virus Diseases (1)
GlaxoSmithKline (3) · Copenhagen University Hospital, Rigshospitalet (2) · Instituto de Investigación Marqués de Valdecilla (2) · St. Paul's Sinus Centre (2) · Azienda Ospedaliero Universitaria di Cagliari (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Eye & ENT Hospital of Fudan University (1) · Helsinki University Central Hospital (1) · Hospices Civils de Lyon (1) · KU Leuven (1) · McMaster University (1) · University of Newcastle, Australia (1) · University of Sao Paulo General Hospital (1) · Vibeke Backer (1) · Western University, Canada (1)
Canada (6) · Spain (4) · Denmark (3) · France (3) · Belgium (2) · Germany (2) · Italy (2) · United States (2) · Argentina (1) · Australia (1) · Brazil (1) · China (1) · Finland (1) · India (1) · Japan (1)
Christian Pedersen, MD (1) · Christian von Buchwald (1) · Gilles Devouassoux, Pr (1) · Grace Parraga, PhD (1) · Huabin Li, PhD (1) · Imran Satia, MD, PhD (1) · Martin Yvon Desrosiers, MD (1) · Peter Wark, MBBS/PhD (1) · Rodrigo A Athanazio, MD, PhD (1) · Sanna Toppila-Salmi, MD PhD, PI (1) · Tatjana Decaesteker (1) · Vibeke B Backer, Professor (1)
2015 (1)