11 completed, 10 terminated, 2 unknown, 1 recruiting. 10 Phase 2, 5 Phase 1, 4 Phase 3, 3 Phase 4, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial Biospecimen Collection, Carboplatin, Cisplatin - Oral Cavity Squamous Cell Carcinoma, Stage I Lip and Oral Cavity Cancer AJCC v8 | Phase 2 | Recruiting | University of Michigan Rogel Cancer Center | 50 | 2025-07-17 | 2026-07-31 |
| Tc 99m Tilmanocept Imaging for Early Prediction of Anti-TNFα Therapy Response in Moderate to Severe Active RA TC99m-tilmanocept - Rheumatoid Arthritis | Phase 3 | Terminated | Navidea Biopharmaceuticals | 169 | 2022-03-02 | 2025-01-23 |
| Evaluating the Ability of 99mTc-Tilmanocept to Identify Clipped Nodes in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy and Sentinel Lymph Node Dissection 99m Tc-TM - Breast Cancer | Terminated | Johns Hopkins University | 14 | 2022-03-01 | 2024-02-09 | |
| Comparison of Tc 99m Tilmanocept Imaging With IHC Analysis of CD206 Expression in Synovial Tissue of Subjects With RA Tc 99m tilmanocept - Rheumatoid Arthritis | Phase 2 | Terminated | Navidea Biopharmaceuticals | 20 | 2021-09-14 | 2025-01-08 |
| Development of a Normative Database for Rheumatoid Arthritis (RA) Imaging With Tc99m Tilmanocept Tc99m tilmanocept - Rheumatoid Arthritis | Phase 2 | Completed | Navidea Biopharmaceuticals | 134 | 2021-05-27 | 2025-01-08 |
| Feasibility of IV Tc-99m-tilmanocept for Imaging of M2-like TAMs in Metastatic Melanoma Tc-99m tilmanocept - Melanoma | Early Phase 1 | Terminated | John O. Prior | 5 | 2021-02-01 | 2023-12-13 |
| Concurrent Use Lymphoseek & Indocyanine Green in Sentinel Lymph Node Detection in Endometrial Cancer Lymphoseek, Single Photon Emission Computed Tomography (SPECT), Indocyanine Green (ICG) - Endometrial Cancer | Phase 2 | Terminated | Stanford University | 6 | 2021-01-20 | 2023-10-11 |
| Study Comparing Lymphoseek® vs. Albumin Nanocolloid in Head and Neck, Melanoma and Breast Cancer Lymphoseek, Nanocoll - Head Cancer, Neck Cancer | Phase 4 | Unknown | Anna Cruceta | 30 | 2020-03-01 | 2020-02-20 |
| Mapping Draining Lymph Nodes in CNS Malignancies Tc-99m tilmanocept - Central Nervous System Neoplasms, Central Nervous System Tumor | Phase 1 | Terminated | Washington University School of Medicine | 14 | 2019-12-03 | 2023-12-21 |
| Panitumumab-IRDye800 Compared to Sentinel Node Biopsy and (Selective) Neck Dissection in Identifying Metastatic Lymph Nodes in Patients With Head&Neck Cancer Panitumumab-IRDye800, Lymphoseek - Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck (SCCHN) | Phase 2 | Completed | Eben Rosenthal | 3 | 2019-08-01 | 2022-11-10 |
| Evaluation of the Precision and Sensitivity of Tilmanocept Uptake Value (TUV) on Tc 99m Tilmanocept Planar Imaging Tc 99m tilmanocept - Rheumatoid Arthritis | Phase 2 | Completed | Navidea Biopharmaceuticals | 116 | 2019-04-08 | 2023-08-24 |
| Safety Evaluation of IV Tc 99m Tilmanocept and Comparison of Imaging With Sulfur Colloid in Subjects With and Without NASH Tc 99M Sulfur Colloid, Tc99m-tilmanocept - Nonalcoholic Steatohepatitis, NASH - Nonalcoholic Steatohepatitis | Phase 1 | Terminated | Navidea Biopharmaceuticals | 6 | 2017-12-06 | 2024-12-24 |
| An Evaluation of Tc 99m Tilmanocept by Intravenous (IV) and Subcutaneous (SC) Injection in Kaposi Sarcoma (KS) Tc99m-tilmanocept - Kaposi Sarcoma, HIV Infections | Phase 1 | Completed | Navidea Biopharmaceuticals | 15 | 2017-12-01 | 2025-03-05 |
| An Evaluation of Tilmanocept by IV Injection Using SPECT/CT vs PET Imaging in Subjects With Liver Metastases. Tilmanocept (Technetium Tc 99m tilmanocept Injection), SPECT/CT Imaging - Liver Metastases, Colorectal Carcinoma | Phase 1 | Terminated | Navidea Biopharmaceuticals | 3 | 2017-07-26 | 2020-09-10 |
| Tilmanocept vs Sulfur Colloid in Sentinel Lymph Node Biopsy Tc 99m tilmanocept, Tc 99m filtered sulfur colloid - Sentinel Lymph Node Biopsy, Breast Cancer | Phase 4 | Unknown | Memorial Health University Medical Center | 86 | 2017-06-22 | 2018-08-24 |
| A Prospective, Open-Label, Multi-center Comparison of Lymphoseek Identified Lymph Nodes and Clinically Identified Lymph Nodes of Subjects With Known Cancer of the Anus Lymphoseek - Anal Cancer | Phase 2 | Withdrawn | Cardinal Health 414, LLC | 2016-09-01 | 2017-03-15 | |
| Evaluation of SC Injected Tc 99m Tilmanocept Localization in Active RA Subjects by SPECT and SPECT/CT Imaging Tilmanocept - Rheumatoid Arthritis | Phase 1 | Completed | Navidea Biopharmaceuticals | 18 | 2016-07-01 | 2019-11-21 |
| A Trial of Comparing the Pathology Status of Lymphoseek®-Identified Sentinel Lymph Nodes Relative to the Pathological Pathology Status of Nonsentinel Lymph Nodes in Nodal Staging of Subjects With Known Cancer of the Cervix Who Are Undergoing Lymph Node Dissection Tc99m tilmanocept - Uterine Cervical Neoplasms | Phase 2 | Terminated | Cardinal Health 414, LLC | 18 | 2016-01-01 | 2019-02-11 |
| A Study of Lymphoseek® as a Lymphoid Tissue Targeting Agent in Pediatric Patients With Melanoma, Rhabdomyosarcoma, or Other Solid Tumors Who Are Undergoing Lymph Node Mapping Tc99m tilmanocept, Vital Blue Dye (optional), Lymph Node Mapping - Rhabdomyosarcoma, Melanoma | Phase 2 | Completed | Cardinal Health 414, LLC | 24 | 2015-08-01 | 2024-06-28 |
| Sentinel Lymph Node Biopsy Findings in Patients With Breast Cancer Lymphoseek, Sulfur Colloid - Breast Cancer | Phase 4 | Completed | Kettering Health Network | 40 | 2015-01-19 | 2020-07-28 |
Showing 20 of 25. Sign in to see all of them.
Breast Neoplasms (7) · Arthritis, Rheumatoid (5) · Melanoma (5) · Squamous Cell Carcinoma of Head and Neck (3) · Head and Neck Neoplasms (2) · Sarcoma, Kaposi (2) · Adenocarcinoma (1) · Anus Neoplasms (1) · Central Nervous System Neoplasms (1) · Colorectal Neoplasms (1) · Disease (1) · Endometrial Neoplasms (1) · HIV Infections (1) · Mouth Neoplasms (1) · Non-alcoholic Fatty Liver Disease (1)
Navidea Biopharmaceuticals (12) · Cardinal Health 414, LLC (3) · Anna Cruceta (1) · Eben Rosenthal (1) · John O. Prior (1) · Johns Hopkins University (1) · Kettering Health Network (1) · Memorial Health University Medical Center (1) · Stanford University (1) · University of California, San Diego (1) · University of Michigan Rogel Cancer Center (1) · Washington University School of Medicine (1)
United States (22) · Israel (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Michael Blue, MD (10) · Amer K Karam, MD (1) · Arash Kardan, MD (1) · Bonnie C Abbruzzese, MS RD (1) · Bonnie C Abbruzzese, MS, RD, CCRA (1) · Fred M Baik (1) · Frederick O Cope, PhD (1) · Jennifer L Shah (1) · Mehran Habibi, MD (1) · Niklaus Schaefer, Prof. (1) · Richard Orahood, M.D. (1) · Simon A Blackburn (1) · Tanner Johanns, M.D., Ph.D. (1) · William Burak, MD (1)
PMID 23054107, PMID 23504141, PMID 24051744, PMID 25670018, PMID 27866590, PMID 35958955, PMID 40913745
2018 (1), 2019 (1), P30CA124435 (1), R01CA190306 (1), R44CA162783 (1), R44CA192859 (1)