6 completed, 2 not yet recruiting, 2 withdrawn, 1 enrolling by invitation. 5 Phase 2, 4 Phase 4, 3 Not applicable, 3 Phase 1.
Follow Low Dose Naltrexone: new trials by email Literature Review of Low Dose Naltrexone trials Research Report on Low Dose Naltrexone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Pilot Study on the Efficacy of Oral Low Dose Naltrexone for Vulvodynia Low Dose Naltrexone - Vulvodynia | Phase 2 | Not yet recruiting | University of Florida | 20 | 2027-01-01 | 2026-10-09 |
| Low Dose Naltrexone Use in Patients With POTS Low Dose Naltrexone, Microcrystalline cellulose - Postural Orthostatic Tachycardia Syndrome | Phase 4 | Not yet recruiting | University of Calgary | 80 | 2026-07-01 | 2026-05-01 |
| Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome Low dose naltrexone, Placebo sugar capsules - Complex Regional Pain Syndrome, Chronic Pain | Phase 4 | Enrolling by invitation | Hospital for Special Surgery, New York | 40 | 2024-01-02 | 2026-06-18 |
| Low Dose Naltrexone for Pain in Patients With HIV Low Dose Naltrexone - Human Immunodeficiency Virus, Chronic Neuropathic Pain | Phase 4 | Recruiting | Emory University | 60 | 2023-04-28 | 2026-04-09 |
| Efficacy of Low Dose Naltrexone in Psoriasis Naltrexone Pill - Psoriasis | Phase 1 | Completed | Jinnah Postgraduate Medical Centre | 42 | 2019-01-01 | 2020-01-31 |
| St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Nalmefene Low dose naltrexone, Nalmefene - HIV Infection, Alcohol Use | Phase 1 / Phase 2 | Completed | Boston Medical Center | 11 | 2018-07-03 | 2020-08-24 |
| Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? Low dose naltrexone, Placebo - Fibromyalgia | Phase 4 | Completed | Copenhagen University Hospital, Rigshospitalet | 58 | 2016-06-01 | 2024-02-23 |
| Low Dose Naltrexone (LDN) Immune Monitoring Low Dose Naltrexone - Fibromyalgia | Not applicable | Completed | University of Alabama at Birmingham | 9 | 2014-03-01 | 2017-04-11 |
| Low Dose Naltrexone in Symptomatic Inflammatory Bowel Disease Low dose naltrexone, Placebo - Inflammatory Bowel Disease, Crohn's Disease | Phase 2 | Withdrawn | Santa Barbara Cottage Hospital | 2013-03-01 | 2014-11-20 | |
| Low Dose Naltrexone for Glioma Patients LDN, Placebo - Malignant Glioma | Phase 2 | Completed | Katy Peters | 110 | 2011-05-01 | 2015-07-17 |
| Low Dose Naltrexone for the Treatment of Juvenile Primary Fibromyalgia Syndrome Low Dose Naltrexone - Fibromyalgia | Not applicable | Withdrawn | Stanford University | 2010-08-01 | 2015-12-11 | |
| Effects of Low Dose Naltrexone in Fibromyalgia Low Dose Naltrexone, Placebo - sugar pill - Fibromyalgia, Persian Gulf Syndrome | Not applicable | Completed | Stanford University | 53 | 2007-06-01 | 2015-10-21 |
| Trial of Low-Dose Naltrexone for Children With Pervasive Developmental Disorder (PDD) low dose naltrexone - Pervasive Developmental Disorder | Phase 1 / Phase 2 | Unknown | Hadassah Medical Organization | 50 | 2006-05-03 |
Fibromyalgia (4) · Pain (3) · Acquired Immunodeficiency Syndrome (1) · Agnosia (1) · Alcohol Drinking (1) · Autistic Disorder (1) · Causalgia (1) · Child Development Disorders, Pervasive (1) · Chronic Pain (1) · Colitis, Ulcerative (1) · Complex Regional Pain Syndromes (1) · Crohn Disease (1) · Glioblastoma (1) · Glioma (1) · HIV Infections (1)
Stanford University (2) · Boston Medical Center (1) · Copenhagen University Hospital, Rigshospitalet (1) · Emory University (1) · Hadassah Medical Organization (1) · Hospital for Special Surgery, New York (1) · Jinnah Postgraduate Medical Centre (1) · Katy Peters (1) · Santa Barbara Cottage Hospital (1) · University of Alabama at Birmingham (1) · University of Calgary (1) · University of Florida (1)
United States (7) · Denmark (1) · Israel (1) · Pakistan (1) · Russia (1)
Jarred Younger (2) · Alexandra Sideris, PhD (1) · Anne M McKenzie-Brown, MD (1) · David S Wilensky, MD (1) · Erick J Imbertson, M.D. (1) · Jarred Younger, PhD (1) · Jeffrey H. Samet, MD, MA, MPH (1) · Katherine B Peters, MD, PhD (1) · Kirsten M Bested, MD (1) · Rabia Ghafoor, FCPS (1) · Satish R Raj, MD MSCI (1) · Sean Mackey (1) · Semih Gungor, M.D. (1)
PMID 23359310, PMID 17222320, PMID 19365548, PMID 21991594, PMID 23188075, PMID 24558033, PMID 30937241, PMID 33682527, PMID 35001215
2015 (1), UH2AA026193 (1)