5 recruiting, 1 active not recruiting, 1 completed, 1 not yet recruiting. 4 Phase 2, 3 Phase 3, 1 Early Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Recruiting 2, Active not recruiting 1, Withdrawn 1 |
| Phase 3 | 3 | Recruiting 2, Not yet recruiting 1 |
| Early Phase 1 | 1 | Recruiting 1 |
| Not applicable | 1 | Completed 1 |
Follow Intensity-Modulated Proton Therapy: new trials by email Literature Review of Intensity-Modulated Proton Therapy trials Research Report on Intensity-Modulated Proton Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Radiation After Surgery to Observation After Surgery in Patients With Clinical Low-Risk, Molecular High-Risk Meningioma, and Evaluating Observation After Surgery in Patients With Clinical and Molecular Low-Risk Meningioma Patient Observation, Magnetic Resonance Imaging, Biospecimen Collection - Grade 1 Meningioma, Grade 2 Meningioma | Phase 3 | Not yet recruiting | NRG Oncology | 464 | 2027-01-28 | 2026-08-25 |
| Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer Intensity-Modulated Radiation Therapy, Volume Modulated Arc Therapy, Pencil Beam Scanning - Astrocytoma, IDH-Mutant, Grade 3 | Phase 3 | Recruiting | Alliance for Clinical Trials in Oncology | 408 | 2026-06-24 | 2026-10-02 |
| Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer Computed Tomography, Fludeoxyglucose F-18, Intensity-Modulated Proton Therapy - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Early Phase 1 | Recruiting | Emory University | 20 | 2024-12-03 | 2025-10-22 |
| A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma 3-Dimensional Conformal Proton Radiation Therapy, 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection - Basal Ganglia Germinoma, Diabetes Insipidus | Phase 2 | Recruiting | Children's Oncology Group | 240 | 2024-10-22 | 2026-08-25 |
| De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA Biospecimen Collection, Cisplatin, Computed Tomography - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 455 | 2023-03-20 | 2026-10-01 |
| Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study Cisplatin, Intensity-Modulated Proton Therapy, Quality-of-Life Assessment - Head and Neck Carcinoma, Head and Neck Carcinoma of Unknown Primary | Phase 2 | Active not recruiting | Mayo Clinic | 174 | 2022-02-16 | 2026-07-16 |
| Re-irradiation With NBTXR3 in Combination With Pembrolizumab for the Treatment of Inoperable Locoregional Recurrent Head and Neck Squamous Cell Cancer Hafnium Oxide-containing Nanoparticles NBTXR3, Intensity-Modulated Proton Therapy, Intensity-Modulated Radiation Therapy - Recurrent Head and Neck Squamous Cell Carcinoma, Unresectable Head and Neck Squamous Cell Carcinoma | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2021-03-09 | 2023-09-13 | |
| Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging 3-Dimensional Conformal Radiation Therapy, Apalutamide, Computed Tomography - Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 804 | 2020-10-08 | 2026-08-19 |
| Vertebral Body Sparing Craniospinal Irradiation for Pediatric Patients With Cancer of the Central Nervous System Intensity-Modulated Proton Therapy, Magnetic Resonance Imaging - Malignant Central Nervous System Neoplasm | Not applicable | Completed | Emory University | 10 | 2019-12-16 | 2024-03-21 |
Oropharyngeal Neoplasms (3) · Carcinoma (2) · Hypopharyngeal Neoplasms (2) · Laryngeal Neoplasms (2) · Squamous Cell Carcinoma of Head and Neck (2) · Astrocytoma (1) · Central Nervous System Neoplasms (1) · Diabetes Insipidus (1) · Germinoma (1) · Lymphatic Metastasis (1) · Lymphoma, Follicular (1) · Mouth Neoplasms (1) · Paranasal Sinus Neoplasms (1) · Prostatic Neoplasms (1) · Salivary Gland Neoplasms (1)
Emory University (2) · Mayo Clinic (2) · Alliance for Clinical Trials in Oncology (1) · Children's Oncology Group (1) · ECOG-ACRIN Cancer Research Group (1) · M.D. Anderson Cancer Center (1) · NRG Oncology (1)
United States (7) · Australia (1) · Canada (1)
Amol M Takalkar, MD, MS, MBA, FACNM (1) · Bree R Eaton (1) · David M, Routman, M.D. (1) · Jack Phan, MD (1) · Mohamed S Abdelbaki (1) · Neha Vapiwala (1) · Patrick Y Wen, MD (1) · Rifaquat M. Rahman, MD (1) · Scott C. Lester, M.D. (1) · Ugonma N Chukwueke, MD (1)
P30CA138292 (2), U10CA180820 (1), U10CA180886 (1)