5 recruiting, 5 unknown, 4 completed, 3 active not recruiting. 20 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 20 | Recruiting 5, Unknown 5, Completed 4, Active not recruiting 3, Enrolling by invitation 2, Terminated 1 |
| Phase 2 | 4 | Enrolling by invitation 2, Active not recruiting 1, Completed 1 |
Follow Induction Chemotherapy: new trials by email Literature Review of Induction Chemotherapy trials Research Report on Induction Chemotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer FOLFOXIRI, CAPOX, FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) - Locally Advanced Rectal Carcinoma | Phase 3 | Recruiting | J. W. A. Burger | 394 | 2026-03-16 | 2026-10-27 |
| Comparing the Efficacy of the LDA, LHAA, and DA Regimens in Young Adults With Low-Risk Acute Myeloid Leukemia Eligible for Intensive Chemotherapy Lisaftoclax+daunorubicin+cytarabine, Lisaftoclax+homoharringtonine+cytarabine+aclarubicin, Daunorubicin+cytarabine - Acute Myeloid Leukemia, Lisaftoclax | Phase 2 / Phase 3 | Enrolling by invitation | First Affiliated Hospital of Zhejiang University | 267 | 2026-03-01 | 2026-06-16 |
| Comparing the Efficacy of LDA, LHAA, and LA Regimens in Young Adults With Intermediate- and High-Risk Acute Myeloid Leukemia Eligible for Intensive Chemotherapy Lisaftoclax+daunorubicin+cytarabine, Lisaftoclax+homoharringtonine+cytarabine+aclarubicin, Lisaftoclax+azacitidine - Acute Myeloid Leukemia (AML), Lisaftoclax | Phase 2 / Phase 3 | Enrolling by invitation | First Affiliated Hospital of Zhejiang University | 450 | 2026-03-01 | 2026-06-16 |
| Phase 3 Trial Comparing IMRT or IMPT Plus CIRT for Patients With NPC Intensity-modulated proton radiation therapy, Intensity-modulated photon radiation therapy, Intensity-modulated carbon ion radiation therapy - Nasopharyngeal Cancinoma (NPC) | Phase 3 | Recruiting | Lin Kong, MD | 470 | 2025-04-01 | 2025-12-02 |
| Phase III Study Evaluating Induction Chemotherapy Followed by Chemoradiotherapy Compared to Standard Chemoradiotherapy for Locally Advanced SCCA induction chemotherapy (mDCF), Concomitant chemotherapy (Capecitabin + Mitomycin-C), radiotherapy - Anal Cancer | Phase 3 | Recruiting | Federation Francophone de Cancerologie Digestive | 310 | 2024-02-26 | 2025-09-02 |
| IC Plus Low-dose Radiation Plus Cadonilimab in LANPC Intensity Modulated Radiation Therapy, Chemotherapy, Immune checkpoint inhibitor - Nasopharyngeal Carcinoma, Immune Checkpoint Inhibitor | Phase 3 | Recruiting | Sun Yat-sen University | 380 | 2024-01-10 | 2026-05-11 |
| Phase III Trial of Concurrent Chemotherapy Alone in Patients With Low-risk Nasopharyngeal Carcinoma IMRT and concurrent cisplatin, gemcitabine and cisplatin (Induction chemotherapy) - Nasopharyngeal Carcinoma | Phase 3 | Active not recruiting | Sun Yat-sen University | 464 | 2023-09-07 | 2026-08-12 |
| Reduced-dose Versus Standard Dose Radiotherapy for Nasopharyngeal Carcinomain IMRT, induction chemotherapy, cisplatin concurrent chemotherapy - Nasopharyngeal Carcinoma | Phase 3 | Active not recruiting | Sun Yat-sen University | 452 | 2022-05-11 | 2025-03-21 |
| ICCRT vs. CRT for Locally Advanced Nasopharyngeal Carcinoma Induction Chemotherapy, Concurrent Chemotherapy, Definitive Radiotherapy - Locally Advanced Nasopharyngeal Carcinoma | Phase 3 | Recruiting | First Affiliated Hospital, Sun Yat-Sen University | 447 | 2021-09-22 | 2021-09-30 |
| Induction Chemotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma Induction chemotherapy, Chemoradiotherapy - Locally Advanced Malignant Neoplasm | Phase 3 | Unknown | Barretos Cancer Hospital | 434 | 2018-12-19 | 2019-07-18 |
| Sequential or Concurrent Chemoradiotherapy in Patients With Locoregionally Advanced NPC gemcitabine and cisplatin (Induction and adjuvant chemotherapy), IMRT, gemcitabine and cisplatin (Induction chemotherapy) - Nasopharyngeal Carcinoma | Phase 3 | Unknown | Chaosu Hu | 420 | 2018-01-01 | 2022-03-04 |
| Sequential Neo-adjuvant Chemotherapy Followed by Capecitabine Vs. Conventional Adjuvant Chemotherapy in Breast Cancer Neo-adjuvant Chemotherapy, Capecitabine - Breast Neoplasm Female | Phase 3 | Unknown | The First Hospital of Jilin University | 1588 | 2016-12-01 | 2017-01-10 |
| International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma Radiotherapy without Carboplatin, Reduced-intensity maintenance chemotherapy, Radiotherapy with Carboplatin - Brain Tumors | Phase 2 / Phase 3 | Active not recruiting | Universitätsklinikum Hamburg-Eppendorf | 360 | 2014-06-01 | 2025-12-04 |
| Randomized Controlled Study on Optimize Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer Induction chemotherapy, Chemoradiotherapy and gap chemotherapy (Capecitabine combine with oxaliplatin), standard chemoradiotherapy - Advanced Rectal Cancer | Phase 3 | Unknown | Sun Yat-sen University | 556 | 2014-01-01 | 2023-08-25 |
| Induction Gemcitabine and Cisplatin in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma gemcitabine and cisplatin (Induction chemotherapy), IMRT and concurrent cisplatin - Nasopharyngeal Carcinoma | Phase 3 | Unknown | Sun Yat-sen University | 480 | 2013-11-01 | 2018-04-24 |
| Maintenance After Induction Chemotherapy in Elderly Patients With Advanced Non-small Cell Lung Cancer Pemetrexed, Gemcitabine, Induction chemotherapy - Non Small Cell Lung Cancer (Squamous or Non Squamous) | Phase 3 | Completed | Intergroupe Francophone de Cancerologie Thoracique | 632 | 2013-05-16 | 2023-03-14 |
| Pancreatic Carcinoma: Chemoradiation Compared With Chemotherapy Alone After Induction Chemotherapy Induction chemotherapy with gemcitabine or FOLFIRINOX, Radiotherapy, 28 x 1.8 Gy, Chemotherapy, gemcitabine - Pancreatic Cancer | Phase 3 | Completed | University of Erlangen-Nürnberg Medical School | 830 | 2013-04-04 | 2024-04-11 |
| Induction Chemotherapy and Chemoradiotherapy in Nasopharyngeal Cancers Induction chemotherapy + concurrent radiochemotherapy vs. concurrent radiochemotherapy - Nasopharyngeal Cancers | Phase 3 | Terminated | Groupe Oncologie Radiotherapie Tete et Cou | 83 | 2009-01-01 | 2019-01-18 |
| Treatment Outcome in Elderly Patients chemotherapy treatment (see arm) + norethandrolone, chemotherapy treatment (see arms) - AML, Elderly Patients | Phase 3 | Completed | University Hospital, Grenoble | 330 | 2002-06-01 | 2008-06-18 |
| Laryngeal Preservation in Pyriform Sinus Carcinoma induction chemotherapy, Conventionnal chemotherapy - Squamous Cell Carcinoma | Phase 2 / Phase 3 | Completed | Centre Hospitalier Universitaire de Saint Etienne | 71 | 2002-02-01 | 2008-10-10 |
Nasopharyngeal Carcinoma (5) · Leukemia, Myeloid, Acute (2) · Anus Neoplasms (1) · Brain Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Squamous Cell (1) · Lung Neoplasms (1) · Medulloblastoma (1) · Nasopharyngeal Neoplasms (1) · Neuroectodermal Tumors, Primitive (1) · Pancreatic Neoplasms (1) · Pathologic Complete Response (1) · Rectal Neoplasms (1)
Sun Yat-sen University (5) · First Affiliated Hospital of Zhejiang University (2) · Barretos Cancer Hospital (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Chaosu Hu (1) · Federation Francophone de Cancerologie Digestive (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Groupe Oncologie Radiotherapie Tete et Cou (1) · Intergroupe Francophone de Cancerologie Thoracique (1) · J. W. A. Burger (1) · Lin Kong, MD (1) · The First Hospital of Jilin University (1) · University Hospital, Grenoble (1) · University of Erlangen-Nürnberg Medical School (1) · Universitätsklinikum Hamburg-Eppendorf (1)
China (11) · France (6) · Germany (2) · Netherlands (2) · Austria (1) · Belgium (1) · Brazil (1) · Czechia (1) · Denmark (1) · Ireland (1) · Italy (1) · Morocco (1) · Norway (1) · Poland (1) · Portugal (1)
Chong Zhao, MD, PhD (1) · Fan Zhimin, Professor (1) · Francois Doz, Prof. Dr. (1) · Hai Qiang Mai, Dr (1) · Jacobus WA Burger, Prof. dr. (1) · Jamel Daoud, Pr (1) · Jun Ma, M.D. (1) · Rainer Fietkau, MD (1) · Till Milde, Dr. med. (1)
PMID 16079161, PMID 16606972, PMID 18502088, PMID 19505212, PMID 19732686, PMID 19906561, PMID 22261362, PMID 27567280, PMID 28129526, PMID 28688693, PMID 31150573, PMID 31640628, PMID 32898792, PMID 35183221, PMID 35709465, PMID 37280275, PMID 40705321, PMID 40802908, PMID 40967259, PMID 42151882, PMID 9215816
2009 (1), 2025 (1)