30 completed, 4 unknown, 1 suspended, 1 terminated. 37 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 37 | Completed 30, Unknown 4, Suspended 1, Terminated 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
Follow Indinavir: new trials by email Literature Review of Indinavir trials Research Report on Indinavir
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment With Indinavir and Chemotherapy for Advanced Classical Kaposi's Sarcoma Indinavir in association with Vinblastina +/- Bleomicina - Kaposi's Sarcoma | Phase 2 | Completed | Barbara Ensoli, MD, PhD | 25 | 2008-06-01 | 2016-08-30 |
| External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases indinavir sulfate, ritonavir, radiation therapy - Cancer | Phase 2 | Unknown | Oncology Institute of Southern Switzerland | 60 | 2007-09-01 | 2013-08-12 |
| The Pharmacokinetics and Safety of IDV/r With NRTIs in HIV/TB Co-infected Patients Receiving Rifampicin indinavir/ritonavir - HIV Infections, Tuberculosis | Phase 1 / Phase 2 | Completed | The HIV Netherlands Australia Thailand Research Collaboration | 20 | 2006-12-01 | 2020-07-17 |
| Treatment of Classical Non-HIV-Related Kaposi's Sarcoma With the Antiviral Drug Indinavir indinavir - Classical Kaposi's Sarcoma | Phase 2 | Completed | Istituto Superiore di Sanità | 28 | 2003-06-01 | 2008-04-14 |
| Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children NRTIs (ABC, FTC, FTC/TDF, 3TC, 3TC/AZT, d4T, TDF, ddC, AZT), NNRTIs (EFV, NVP), PIs (AMP, IDV, LPV/r, NFV, SQV, RTV) - HIV Infections | Phase 2 / Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 266 | 2002-08-01 | 2021-11-05 |
| Efficacy and Tolerability of an Antiretroviral Bi-Therapy in HIV Infected Patients With Multidrug Resistance Indinavir, Lamivudine, Ritonavir - HIV Infections | Phase 2 | Terminated | French National Agency for Research on AIDS and Viral Hepatitis | 40 | 2002-02-01 | 2007-01-18 |
| A Study of Indinavir Plus Ritonavir Plus Two NRTIs vs. Nelfinavir Plus Two NRTIs in HIV Positive Patients (0639-112)(COMPLETED) MK0639, indinavir sulfate / Duration of Treatment: 48 Weeks, Comparator: nelfinavir mesylate / Duration of Treatment: 48 Weeks - HIV Infections | Phase 2 | Completed | Merck Sharp & Dohme LLC | 330 | 2001-01-01 | 2017-02-17 |
| A Study to Compare the Safety and Effectiveness of Two Dosing Schedules of Lamivudine in Combination With Two Other Anti-HIV Drugs Indinavir sulfate, Nelfinavir mesylate, Lamivudine - HIV Infections | Phase 2 | Completed | Glaxo Wellcome | 1999-06-01 | 2005-06-24 | |
| A Study to Compare Two Anti-HIV Drug Combinations That Include Amprenavir in HIV-Infected Patients Who Have Failed Anti-HIV Drug Combinations That Did Not Include Amprenavir Indinavir sulfate, Abacavir sulfate, Amprenavir - HIV Infections | Phase 2 | Completed | Glaxo Wellcome | 100 | 1999-03-01 | 2005-06-24 |
| Paclitaxel in Treating Patients With AIDS-Related Kaposi's Sarcoma indinavir sulfate, nelfinavir mesylate, paclitaxel - Sarcoma | Phase 2 | Completed | Eastern Cooperative Oncology Group | 33 | 1997-12-15 | 2023-06-15 |
| A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas therapeutic autologous dendritic cells, indinavir sulfate, peripheral blood stem cell transplantation - Ewing's Sarcoma, Rhabdomyosarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 42 | 1996-12-01 | 2012-06-15 |
| Safety and Effectiveness of Giving Indinavir, Ritonavir, Stavudine, and Lamivudine to HIV-Infected Patients Who Have Never Received Anti-HIV Drugs Indinavir sulfate, Ritonavir, Lamivudine - HIV Infections | Phase 2 | Unknown | Merck Sharp & Dohme LLC | 8 | 2005-06-24 | |
| A Study of the Safety and Effectiveness of Hydroxyurea in Patients on Potent Antiretroviral Therapy and Who Have Less Than 200 Copies/ml of HIV RNA in Their Blood Indinavir sulfate, Lamivudine/Zidovudine, Hydroxyurea - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 399 | 2021-10-29 | |
| A Phase II Study of Intermittent Recombinant Human Interleukin-2 (rhIL-2) by Intravenous or Subcutaneous Administration in Subjects With HIV Infection on Highly Active Antiretroviral Therapy (HAART) Compared to HAART Alone Indinavir sulfate, Lamivudine, Stavudine - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 200 | 2012-05-21 | |
| Safety and Effectiveness of an Anti-HIV Drug Combination in HIV-Positive Patients Who Have Failed Previous Treatment With Protease Inhibitors Indinavir sulfate, Ritonavir - HIV Infections | Phase 2 | Completed | Merck Sharp & Dohme LLC | 30 | 2005-06-24 | |
| A Study of Three Anti-HIV Drug Combinations in Patients Who Have Taken Amprenavir Indinavir sulfate, Amprenavir, Nevirapine - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 94 | 2021-11-04 | |
| Safety and Effectiveness of an Anti-HIV Drug Combination Taken Twice Daily Indinavir sulfate, Ritonavir, Lamivudine - HIV Infections | Phase 2 | Unknown | Merck Sharp & Dohme LLC | 80 | 2005-06-24 | |
| Using Drug Levels and Drug Resistance Testing to Select Effective Anti-HIV Drug Combinations in Patients With Drug-resistant HIV lopinavir/ritonavir, indinavir sulfate, tenofovir disoproxil fumarate - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 53 | 2021-11-01 | |
| A Study on the Safety and Effectiveness of L-756423 Plus Indinavir in HIV-Positive Patients Who Have Previously Taken Indinavir L-756423, Indinavir sulfate - HIV Infections | Phase 2 | Completed | Merck Sharp & Dohme LLC | 30 | 2005-06-24 | |
| Comparison of New Anti-HIV Drug Combinations in HIV-Infected Children Who Have Taken Anti-HIV Drugs Indinavir sulfate, Ritonavir, Nevirapine - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 240 | 2021-11-04 |
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HIV Infections (32) · Acquired Immunodeficiency Syndrome (3) · Sarcoma, Kaposi (2) · AIDS-Related Complex (1) · AIDS-related Kaposi sarcoma (1) · Adenocarcinoma, Follicular (1) · Adrenocortical Carcinoma (1) · Anus Neoplasms (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Ovarian Epithelial (1) · Carcinoma, Renal Cell (1) · Colonic Neoplasms (1)
National Institute of Allergy and Infectious Diseases (NIAID) (17) · Merck Sharp & Dohme LLC (8) · Glaxo Wellcome (4) · Barbara Ensoli, MD, PhD (1) · Eastern Cooperative Oncology Group (1) · French National Agency for Research on AIDS and Viral Hepatitis (1) · Gilead Sciences (1) · Istituto Superiore di Sanità (1) · National Cancer Institute (NCI) (1) · Oncology Institute of Southern Switzerland (1) · The HIV Netherlands Australia Thailand Research Collaboration (1)
United States (30) · Puerto Rico (10) · Italy (2) · France (1) · Switzerland (1) · Tanzania (1) · Thailand (1)
Scott Hammer (3) · Collier A (2) · Ann J. Melvin, MD (1) · Barbara Ensoli, MD, PhD (1) · Benson CA (1) · Chaisson RE (1) · Constance Benson (1) · Coombs R (1) · Crystal Mackall, M.D. (1) · Currier JS (1) · Dan Kuritzkes (1) · Dominique Costagliola (1) · Douglas Richman, MD (1) · Elaine Abrams (1) · Elizabeth Connick (1)
PMID 10659875, PMID 11840078, PMID 11980557, PMID 15687448, PMID 17280617, PMID 17726714, PMID 18215978, PMID 18676758, PMID 21239359, PMID 21288774, PMID 21337357, PMID 22250979