21 completed, 11 unknown, 4 recruiting, 3 terminated. 34 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 34 | Completed 18, Unknown 10, Recruiting 3, Terminated 2, Withdrawn 1 |
| Phase 2 | 1 | Unknown 1 |
Follow HFNC: new trials by email Literature Review of HFNC trials Research Report on HFNC
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact on Mortality of a Strategy Including Continuous Positive Airway Pressure Plus High Flow Nasal Cannula Oxygen Therapy Versus High Flow Nasal Cannula Oxygen Therapy Alone in Patients With de Novo Acute Hypoxemic Respiratory Failure: a Prospective, Randomized Controlled Trial. HFNC, CPAP and HFNC - De Novo Hypoxemic Acute Respiratory Failure (hARF) | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 1084 | 2025-08-19 | 2026-04-13 |
| Noninvasive Ventilation Versus High-Flow Nasal Cannula After Extubation in High-Risk ICU Patients NIV, HFNC - Extubation Failure | Not applicable | Completed | Benha University | 102 | 2025-07-30 | 2026-06-11 |
| Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure HFNC, NIV - Respiratory Failure | Not applicable | Recruiting | Minia University | 75 | 2025-06-01 | 2026-04-09 |
| HFNC vs NIPPV Following Extubation High Flow Nasal Canula following extubation, Non-Invasive Positive Pressure Ventilation following extubation - Congenital Heart Disease | Not applicable | Recruiting | Emory University | 200 | 2025-02-27 | 2026-07-14 |
| Comparison Physiological Effects According to Preoxygenation Method Using EIT HFNC - Acute Hypoxemic Respiratory Failure | Not applicable | Withdrawn | Samsung Medical Center | 2023-08-01 | 2024-04-17 | |
| The Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) Study HFNC, CPAP, Standard Oxygen - Acute Respiratory Failure With Hypoxia, Acute Respiratory Distress Syndrome | Not applicable | Completed | Makerere University | 705 | 2023-03-13 | 2025-08-14 |
| Comparative Study on the Effectiveness, Comfort and Compliance of HFNC and Noninvasive Mechanical Ventilation BiPAP Mode in the Treatment of Hypoxemia Patients Non-invasive BiPAP ventilation, HFNC - Hypoxemia | Not applicable | Unknown | Qilu Hospital of Shandong University | 243 | 2023-03-01 | 2023-03-27 |
| HFNC in Management of Bronchiectasis Exacerbation bi-level ventillation - Bronchiectasis | Recruiting | Assiut University | 20 | 2023-03-01 | 2026-09-24 | |
| Effects of High-flow Oxygen Therapy and Non-invasive Ventilation on Lung Volumes and on Upper Airway HFNC, NIV - Respiratory Failure | Not applicable | Unknown | University Hospital, Montpellier | 56 | 2023-01-27 | 2024-05-29 |
| Physiological Effects of High-flow Nasal Cannula During Exercise High-flow Nasal Cannula - Healthy Volunteers | Not applicable | Completed | Pontificia Universidad Catolica de Chile | 14 | 2022-07-25 | 2023-12-07 |
| HFNC Versus SOT During EBUS Standard oxygen therapy, HFNC - Endobronchial Ultrasound | Not applicable | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 300 | 2022-06-10 | 2024-08-14 |
| HFNC Versus Oxygen Face Mask on Postoperative Pulmonery Complications HFNC, Oxygen face mask - Post Operative Pulmonary Complications | Not applicable | Completed | Alexandria University | 94 | 2021-04-30 | 2022-09-21 |
| High Flow Nasal Cannula With Noninvasive Ventilation Standard of Care - Nasal Cannula, High-flow nasal cannula, HFNC plus non-invasive ventilation - Acute Respiratory Failure | Not applicable | Completed | University of Oklahoma | 6 | 2020-09-01 | 2023-11-21 |
| The Physiologic Effect of the Flow Generated by High Flow Nasal Cannula in Mild Respiratory Failure HFNC - Respiratory Failure | Not applicable | Completed | Hadassah Medical Organization | 28 | 2020-08-01 | 2023-02-01 |
| High Flow Nasal Cannula Oxygen During Sedation for Video-assisted Thoracoscopic Surgery High flow nasal cannula, CONTROL - Chronic Obstructive Pulmonary Disease, Respiratory Failure | Phase 2 | Unknown | Alexandria University | 60 | 2020-08-01 | 2020-08-20 |
| HFNC and NIV for COVID-19 Complicated by Respiratory Failure HFNC - Respiratory Failure | Completed | Chinese University of Hong Kong | 26 | 2020-06-11 | 2022-07-25 | |
| Helmet CPAP Versus HFNC in COVID-19 Helmet CPAP, HFNC - COVID, Acute Hypoxemic Respiratory Failure | Not applicable | Terminated | Lund University | 2 | 2020-06-03 | 2021-04-15 |
| High Flow Nasal Cannula HFNC In Covid-19 Patients High flow nasal cannula HFNC - SARS-CoV Infection, SARS (Severe Acute Respiratory Syndrome) | Not applicable | Unknown | Lahore General Hospital | 30 | 2020-05-01 | 2020-12-08 |
| Postextubation Management in Patients at Risk for Extubation Failure BiPAP, HFNC - Ventilatory Failure | Not applicable | Terminated | OhioHealth | 6 | 2020-02-11 | 2022-01-13 |
| The Physiological Effect of High Flow Oxygen Therapy HFNC, NPPV - High-flow Nasal Cannula, Non-invasive Positive Pressure Ventilation | Not applicable | Unknown | The First Affiliated Hospital of Guangzhou Medical University | 10 | 2019-12-27 | 2019-12-30 |
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Respiratory Insufficiency (12) · Pulmonary Disease, Chronic Obstructive (5) · Bronchiolitis (2) · COVID-19 (2) · Hypercapnia (2) · Hypoxia (2) · Acidosis, Respiratory (1) · Acute Lung Injury (1) · Asthma (1) · Bronchiectasis (1) · Bronchopulmonary Dysplasia (1) · Dyspnea (1) · Heart Defects, Congenital (1) · Hypoventilation (1) · Motor Activity (1)
Alexandria University (2) · Poitiers University Hospital (2) · University Hospital, Montpellier (2) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Benha University (1) · Chang Gung University (1) · Children's Hospital Medical Center, Cincinnati (1) · Chinese PLA General Hospital (1) · Chinese University of Hong Kong (1) · Emory University (1) · Guilherme Sant'Anna, MD (1) · Hadassah Medical Organization (1) · Hospices Civils de Lyon (1) · Hospital Italiano de Buenos Aires (1)
France (7) · United States (6) · Egypt (5) · Canada (4) · China (3) · Argentina (1) · Brazil (1) · Chile (1) · Hong Kong (1) · India (1) · Israel (1) · Italy (1) · Netherlands (1) · Pakistan (1) · South Korea (1)
Ahmad M. Shaddad (1) · Ahmed EL-Attar, MD (1) · Arthur Kwizera, MD (1) · Asaad Beshish, MD (1) · Carl B. Shanholtz, MD (1) · Celia Y Quang, MD (1) · Chun Pan, Dr (1) · David S Hui, MD (1) · Dedong Ma, MD (1) · Dirceu Costa (1) · Fuxi Sun, Dr (1) · Guilherme M Sant'Anna, MD, PhD (1) · Hui-Ling Lin, MSc (1)
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