10 completed, 5 unknown, 2 active not recruiting, 2 terminated. 7 Phase 1, 7 Phase 2, 3 Phase 3, 2 Not applicable, 2 Phase 4.
Follow GnRH: new trials by email Literature Review of GnRH trials Research Report on GnRH
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA) Follitropin alfa/lutropin alfa (MBJ-0011), hMG, Cetrorelix acetate - Infertility | Phase 3 | Recruiting | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 266 | 2026-02-04 | 2026-09-08 |
| Recall by Genotype: Neuropeptide Stimulation kisspeptin 112-121, GnRH - Reproductive Disorder | Phase 1 | Terminated | Stephanie B. Seminara, MD | 16 | 2023-10-20 | 2026-03-06 |
| Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men Testosterone, GnRH - Hypogonadism, Male, Testosterone Deficiency | Unknown | Royal College of Surgeons, Ireland | 60 | 2023-03-12 | 2023-03-17 | |
| Goserline Acetate VS Dienogest in Endometriosi Zoladex, Visanne - Endometriosis | Phase 4 | Unknown | Mansoura University | 40 | 2020-12-25 | 2021-10-20 |
| Conventional Androgen Deprivation Therapy (ADT) With or Without Abiraterone Acetate + Prednisone and Apalutamide Following a Detectable PSA After Radiation and ADT Prednisone, Apalutamide, Abiraterone Acetate - Prostate Cancer | Phase 3 | Terminated | Dana-Farber Cancer Institute | 12 | 2020-04-20 | 2024-09-19 |
| Testing the Addition of a New Anti-Cancer Drug, Niraparib, to the Usual Treatment (Hormone and Radiation Therapy) for Prostate Cancer With a High Chance of Recurring Gonadotrophin Releasing Hormone, Intensity-Modulated Radiation Therapy, Niraparib - Prostate Adenocarcinoma, Stage IIC Prostate Cancer AJCC v8 | Phase 1 / Phase 2 | Completed | NRG Oncology | 22 | 2019-10-08 | 2026-07-10 |
| Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism kisspeptin 112-121, GnRH - Hypogonadotropic Hypogonadism | Phase 2 | Completed | Stephanie B. Seminara, MD | 18 | 2019-05-03 | 2026-08-26 |
| Randomized Phase II Study of Salvage XRT + ADT +/- Abiraterone and Apalutamide for Rising PSA After RP (FORMULA-509) GnRH, Bicalutamide, Salvage radiation - Prostate Cancer | Phase 2 | Unknown | Dana-Farber Cancer Institute | 345 | 2017-11-24 | 2024-05-14 |
| Administration of Kisspeptin in Patients With Hyperprolactinemia Kisspeptin 112-121, GnRH - Hyperprolactinemia, Hypogonadism | Phase 2 | Completed | Massachusetts General Hospital | 36 | 2017-11-17 | 2024-10-01 |
| Reprometabolic Syndrome Mediates Subfertility in Obesity Insulin, Intralipid, Dextrose - Obesity, Infertility | Not applicable | Active not recruiting | University of Colorado, Denver | 84 | 2016-06-01 | 2026-03-02 |
| GnRH for Luteal Support in IVF/ICSI/FET Cycles GnRH, placebo - Infertility | Phase 4 | Active not recruiting | University Reproductive Associates | 350 | 2015-11-01 | 2026-10-19 |
| Effects of Dietary Omega-3 Fatty Acids on Reproductive Hormones in Obese Women LOVAZA, GnRH - Obesity, Fertility | Not applicable | Completed | University of Colorado, Denver | 39 | 2014-07-01 | 2017-02-02 |
| Neuropeptides in Human Reproduction Kisspeptin 112-121, Naloxone, GnRH - Hypogonadotropic Hypogonadism | Phase 1 | Completed | Massachusetts General Hospital | 61 | 2014-04-30 | 2024-07-31 |
| Kisspeptin in the Evaluation of Delayed Puberty kisspeptin 112-121, GnRH - Delayed Puberty, Kallmann Syndrome | Phase 1 | Completed | Massachusetts General Hospital | 24 | 2013-06-08 | 2023-10-19 |
| Cabazitaxel With Radiation and Hormone Therapy for Prostate Cancer Cabazitaxel, Intensity Modulated Radiation Therapy (IMRT), Anti-Androgen Therapy: Bicalutamide - Prostate Cancer | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 20 | 2011-09-22 | 2025-05-15 |
| Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling kisspeptin 112-121, GnRH - Hypogonadotropic Hypogonadism, Healthy Postmenopausal Women | Phase 1 | Completed | Massachusetts General Hospital | 96 | 2011-09-01 | 2022-07-11 |
| Kisspeptin Administration in the Adult kisspeptin 112-121, GnRH - Hypogonadotropic Hypogonadism, Kallmann Syndrome | Phase 1 | Completed | Massachusetts General Hospital | 256 | 2009-06-23 | 2024-07-31 |
| The Effects of Aging and Estrogen on the Pituitary GnRH, NAL-GLU GnRH antagonist, Estrogen patch - Healthy | Phase 2 / Phase 3 | Unknown | Massachusetts General Hospital | 19 | 2002-01-01 | 2017-04-13 |
| Rapid Hormonal Cycling as Treatment for Patients With Prostate Cancer: The Men's Cycle GnRH, Ketoconazole, Bicalutamide - Prostate, Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 36 | 2001-07-01 | 2016-03-25 |
| Pulsatile GnRH in Anovulatory Infertility GnRH, Pump - Hypogonadotropic Hypogonadism, Amenorrhea | Phase 2 | Unknown | Massachusetts General Hospital | 270 | 1989-01-01 | 2017-07-12 |
Hypogonadism (7) · Infertility (5) · Prostatic Neoplasms (5) · Kallmann Syndrome (3) · Obesity (3) · Hyperprolactinemia (2) · Amenorrhea (1) · Cardiovascular Diseases (1) · Diabetes Mellitus (1) · Endometriosis (1) · Eunuchism (1) · Gonadal Dysgenesis (1) · Hyperinsulinism (1) · Metabolic Diseases (1) · Metabolic Syndrome (1)
Massachusetts General Hospital (7) · Dana-Farber Cancer Institute (2) · Stephanie B. Seminara, MD (2) · University of Colorado, Denver (2) · Mansoura University (1) · Memorial Sloan Kettering Cancer Center (1) · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany (1) · NRG Oncology (1) · Royal College of Surgeons, Ireland (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · University Reproductive Associates (1)
United States (17) · Canada (1) · Egypt (1) · Ireland (1) · Japan (1)
Stephanie B Seminara, MD (5) · Janet E Hall, M.D. (2) · Alaa Mosbah (1) · Alex Polotsky, MD, MS (1) · Anthony D'Amico, MD, PhD (1) · Howard Scher, MD (1) · M. D Michaelson (1) · Nanette Santoro, MD (1) · Paul Nguyen, MD (1) · Peter G McGovern, MD (1) · Robert Den, MD (1) · Stephanie Seminara (1) · Stephanie Seminara, MD (1)
PMID 29669934, PMID 31132118, PMID 19549740, PMID 20133465, PMID 23341491, PMID 25226293, PMID 26523525, PMID 28368443, PMID 30773100, PMID 32034419, PMID 32232399, PMID 33838870, PMID 38710978, PMID 39965102, PMID 41273106, PMID 42230485
P50HD104224 (1), R01AG013241 (1), U10CA180868 (1), U54HD028138 (1), U54HD058155 (1), UL1TR001082 (1)