16 completed, 1 terminated, 1 unknown, 1 withdrawn. 19 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 19 | Completed 16, Terminated 1, Unknown 1, Withdrawn 1 |
Follow Gliclazide: new trials by email Literature Review of Gliclazide trials Research Report on Gliclazide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Study of Sitagliptin and Gliclazide With Metformin in Type 2 Diabetes Patients With Glucotoxicity Sitagliptin and Gliclazide, Metformin - Type 2 Diabetes Mellitus, Glucotoxicity | Phase 4 | Completed | Zhibin Xu | 129 | 2024-06-01 | 2024-09-26 |
| Renal Actions of Combined Empagliflozin and LINagliptin in Type 2 diabetES EMPA/LINA 10/5 mg QD (n=22), LINA/EMPA 5/10 mg QD (N=22), Gliclazide 30 mg QD/BID (N=22) - Type2 Diabetes | Phase 4 | Unknown | M.H.H. Kramer | 66 | 2017-11-09 | 2022-01-14 |
| Effect of Anti-diabetic Drugs on Glycemic Variability Dapagliflozin, Gliclazide MR - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Centro de Diabetes Curitiba Ltda | 135 | 2016-10-01 | 2020-03-04 |
| Canagliflozin (Invokana™) vs. Standard Dual Therapy Regimen for T2DM During Ramadan Canagliflozin, Repaglinide, Pioglitazone - Diabetes Mellitus, Type 2 | Phase 4 | Completed | University of Leicester | 25 | 2016-07-01 | 2020-01-30 |
| Renoprotective Effects of Dapagliflozin in Type 2 Diabetes Dapagliflozin 10mg QD, Gliclazide 30mg QD - Diabetes Mellitus, Type 2, Diabetic Nephropathies | Phase 4 | Completed | M.H.H. Kramer | 44 | 2016-02-01 | 2020-07-07 |
| Effect of Dapagliflozin on Vascular Functions in Patients With Type 2 Diabetes Compared to Gliclazide Dapagliflozin, Gliclazide - Diabetes | Phase 4 | Completed | Seoul National University Bundang Hospital | 32 | 2015-11-01 | 2018-09-11 |
| Sulphonylurea Receptor Mutation and Responsiveness to Gliclazide - a Pilot Proof of Concept, Randomised Cross-over Study Gliclazide, Glibenclamide - Diabetes | Phase 4 | Completed | Khoo Teck Puat Hospital | 8 | 2014-08-01 | 2016-09-01 |
| Antidiabetic Effects on Intrahepatic Fat Liraglutide, Metformin, Gliclazide - Non-Alcoholic Fatty Liver Disease, Type2 Diabetes | Phase 4 | Completed | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 87 | 2014-05-01 | 2017-03-01 |
| Safety Evaluation of Adverse Reactions in Diabetes Exenatide, Linagliptin, Gliclazide - Type 2 Diabetes Mellitus | Phase 4 | Completed | Charles University, Czech Republic | 42 | 2013-10-01 | 2018-02-07 |
| MASTERMIND - Understanding Individual Variation in Treatment Response in Type 2 Diabetes Gliclazide 80mg OD, Sitagliptin 100mg OD - Type 2 Diabetes | Phase 4 | Completed | Royal Devon and Exeter NHS Foundation Trust | 143 | 2013-04-01 | 2018-06-21 |
| Vildagliptin Compared to Gliclazide as Dual Therapy With Metformin in Muslim Patients With Type 2 Diabetes Fasting During Ramadan Vildagliptin, Gliclazide, Metformin - Type 2 Diabetes Mellitus | Phase 4 | Completed | Novartis Pharmaceuticals | 557 | 2013-01-01 | 2013-10-17 |
| Effect of Anti-diabetic Drugs on Bone Metabolism and Glycemic Variability Vildagliptin, Gliclazide MR - Type 2 Diabetes Mellitus, Menopause | Phase 4 | Completed | Centro de Diabetes Curitiba Ltda | 56 | 2012-12-01 | 2016-11-04 |
| A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313) Metformin, Sitagliptin, Acarbose - Type 2 Diabetes Mellitus | Phase 4 | Completed | Merck Sharp & Dohme LLC | 5570 | 2012-11-08 | 2018-08-21 |
| JanUmet Before Insulin Lantus In Eastern Population Evaluation Program (JUBILEE) In Type 2 Diabetic Patients Janumet, Lantus, metformin, gliclazide, protaphane - Type 2 Diabetes Mellitus | Phase 4 | Completed | Chinese University of Hong Kong | 71 | 2011-05-01 | 2015-08-24 |
| Comparison of Repaglinide and Gliclazide in Chinese Subjects With Type 2 Diabetes Never Received Oral Antidiabetic Drug Treatment repaglinide, gliclazide - Diabetes, Diabetes Mellitus, Type 2 | Phase 4 | Completed | Novo Nordisk A/S | 440 | 2009-11-01 | 2014-07-09 |
| Response To Oral Agents in Diabetes (ROAD)- Pilot Study Gliclazide MR, Sitagliptin, Pioglitazone - Diabetes Mellitus, Type 2 | Phase 4 | Completed | University of Dundee | 29 | 2008-12-01 | 2017-10-26 |
| Variation in Sulphonylurea Response in Type 2 Diabetes gliclazide - Diabetes Mellitus, Type 2 | Phase 4 | Terminated | NHS Tayside | 14 | 2007-06-01 | 2018-05-03 |
| Insulin Glargine in Type 2 Diabetic Patients Insulin Glargine, Glyburide, Glyclazide - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Sanofi | 387 | 2006-06-01 | 2009-09-15 |
| Study Protocol for Rosiglitazone Versus Gliclazide in Diabetics With Angina Rosiglitazone, Gliclazide (Comparison drug) - Angina Pectoris, Diabetes Mellitus, Type 2 | Phase 4 | Withdrawn | University of Glasgow | 60 | 2006-09-08 |
Diabetes Mellitus, Type 2 (16) · Diabetes Mellitus (5) · Diabetic Nephropathies (2) · Angina Pectoris (1) · Atherosclerosis (1) · Bone Diseases, Metabolic (1) · Cardiovascular Diseases (1) · Coronary Artery Disease (1) · Hypoglycemia (1) · Non-alcoholic Fatty Liver Disease (1) · Osteoporosis (1)
Centro de Diabetes Curitiba Ltda (2) · M.H.H. Kramer (2) · Charles University, Czech Republic (1) · Chinese University of Hong Kong (1) · Khoo Teck Puat Hospital (1) · Merck Sharp & Dohme LLC (1) · NHS Tayside (1) · Novartis Pharmaceuticals (1) · Novo Nordisk A/S (1) · Royal Devon and Exeter NHS Foundation Trust (1) · Sanofi (1) · Seoul National University Bundang Hospital (1) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (1) · University of Dundee (1) · University of Glasgow (1)
United Kingdom (6) · China (4) · Brazil (2) · Netherlands (2) · Singapore (2) · Czechia (1) · Denmark (1) · Egypt (1) · Germany (1) · Hong Kong (1) · Indonesia (1) · Jordan (1) · Kuwait (1) · Lebanon (1) · Malaysia (1)
Andre GD Vianna, MD (2) · Ewan R Pearson (2) · Andrew T Hattersley, FRCP, DM, BM (1) · Bruno Jolain (1) · Dalong Zhu, MD,PhD (1) · Mark HH Kramer, MD PhD (1) · Mark HH Kramer, MD/PhD (1) · Martin Haluzik, MD DSc (1) · Melanie J Davies, MBBS MD FRCP FRCGP (1) · Naveed Sattar, MBChB PhD (1) · Stuart M Cobbe, MBChB MD (1)
PMID 37435938, PMID 24920915, PMID 28271251, PMID 28515791, PMID 31816432, PMID 32200854, PMID 32516291, PMID 33205810, PMID 35221224, PMID 35322793, PMID 38770818, PMID 41665872
2015 (1)