10 terminated. 10 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Terminated 10 |
| Phase 1 | 2 | Terminated 2 |
| Phase 3 | 1 | Terminated 1 |
Follow Epinephrine: new trials by email Literature Review of Epinephrine trials Research Report on Epinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial Epinephrine 0.5 mcg/kg, Epinephrine 1 mcg/kg - Hypotension | Phase 2 | Terminated | Boston Children's Hospital | 15 | 2023-02-08 | 2026-07-07 |
| Study Assessing Pain Relief After Replacement of the Knee ATX-101, bupivacaine hydrochloride without epinephrine - Acute Postoperative Pain | Phase 2 | Terminated | Allay Therapeutics, Inc. | 112 | 2022-06-07 | 2025-08-14 |
| "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors" Exparel Injectable Product, Multi-Drug Cocktail (Ropivicaine, Epinephrine, Ketolorac, Clonidine) - Musculoskeletal Diseases, Soft Tissue Mass | Phase 2 | Terminated | Atlantic Health System | 116 | 2021-01-27 | 2025-04-09 |
| Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section Bupivacaine, Morphine, Fentanyl - Pain, Referred | Phase 2 | Terminated | Montefiore Medical Center | 26 | 2018-07-19 | 2020-01-13 |
| Nebulized Adrenalin and Oral Betamethasone in Children With Bronchiolitis Attending Pediatric Emergencies. 0.9% saline solution, oral betamethasone placebo, adrenaline - Children, Bronchiolitis | Phase 2 / Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 195 | 2015-10-01 | 2017-09-12 |
| Femoral Nerve Block for Femur Fracture Repair in Pediatrics Ropivicaine, Epinephrine - Traumatic Femur Fracture | Phase 2 | Terminated | Nationwide Children's Hospital | 19 | 2013-05-01 | 2018-01-25 |
| Assessment and Evaluation of Pharmacokinetic Profile of E004 in Healthy Adults Arm T Epinephrine Inhalation Aerosol HFA, 125 mcg, 1 inhalation, Arm C-Epinephrine Inhalation Aerosol CFC - Asthma | Phase 1 / Phase 2 | Terminated | Amphastar Pharmaceuticals, Inc. | 21 | 2012-11-01 | 2016-03-17 |
| Randomized, Placebo/Active Crossover Dose-ranging Study for Safety and Efficacy in Asthma Patients. E004 (epinephrine inhalation aerosol), 90 mcg/actuation, E004 Placebo, E004 (epinephrine inhalation aerosol), 125 mcg - Asthma | Phase 1 / Phase 2 | Terminated | Amphastar Pharmaceuticals, Inc. | 9 | 2009-12-01 | 2018-05-16 |
| Mechanisms of Hypoglycemia Associated Autonomic Failure naloxone, fructose, exercise - Diabetes Mellitus, Hypoglycemia | Phase 2 | Terminated | Albert Einstein College of Medicine | 39 | 2008-03-01 | 2026-05-19 |
| Treatment of Ventricular Tachyarrhythmias Refractory To Shock With Beta Blockers: The SHOCK and BLOCK Trial Epinephrine, Metoprolol - Cardiac Arrest, Sudden Cardiac Death | Phase 2 | Terminated | David Haines, MD | 7 | 2007-01-01 | 2017-05-25 |
Asthma (2) · Bronchiolitis (1) · Death, Sudden, Cardiac (1) · Diabetes Mellitus (1) · Dyspnea (1) · Heart Arrest (1) · Hypoglycemia (1) · Hypotension (1) · Musculoskeletal Diseases (1) · Pain, Postoperative (1) · Pain, Referred (1) · Pure Autonomic Failure (1) · Respiratory Sounds (1) · Status Asthmaticus (1) · Tachycardia, Ventricular (1)
Amphastar Pharmaceuticals, Inc. (2) · Albert Einstein College of Medicine (1) · Allay Therapeutics, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Atlantic Health System (1) · Boston Children's Hospital (1) · David Haines, MD (1) · Montefiore Medical Center (1) · Nationwide Children's Hospital (1)
United States (8) · Australia (1) · Canada (1) · France (1) · United Kingdom (1)
Catherine E Ross, MD (1) · David E Haines, MD (1) · Jeffrey Bernstein, MD (1) · Jim Shi, M.D., Ph.D. (1) · Meredith Hawkins, M.D., M.S. (1) · Nicole Elsey, MD (1) · Vladimir Evilevitch, M.D. (1)
PMID 22285545, PMID 22522612, PMID 26447426, PMID 26447431, PMID 2674208, PMID 28860128, PMID 32150492
2015 (1), K23HL148312 (1), R01DK079974 (1)