10 completed, 3 recruiting, 3 unknown, 2 active not recruiting. 8 Phase 2, 5 Phase 4, 4 Phase 3, 2 Not applicable, 1 Phase 1.
Follow Doxycycline hyclate: new trials by email Literature Review of Doxycycline hyclate trials Research Report on Doxycycline hyclate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African Women Doxycycline hyclate, Standard of Care for STI prevention - Sexually Transmitted Infection (STI), Gonorrhea | Phase 3 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 580 | 2026-11-30 | 2026-10-20 |
| Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO) Doxycycline Hyclate - Bacterial Sexually Transmitted Diseases | Not applicable | Recruiting | Jonathan Troy Grennan | 560 | 2023-06-02 | 2024-08-05 |
| Doxycycline in Cutaneous Schwannoma (NF2) Doxycycline Injection [Doxy] - Neurofibromatosis Type 2 | Phase 1 / Phase 2 | Active not recruiting | Massachusetts Eye and Ear Infirmary | 19 | 2022-09-19 | 2026-10-16 |
| Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne Spironolactone, Doxycycline Hyclate - Acne | Phase 4 | Active not recruiting | University of Pennsylvania | 350 | 2022-03-30 | 2026-08-25 |
| Multi-model Image of Doxycycline in TAO Doxycycline Hyclate - Thyroid Associated Ophthalmopathy | Not applicable | Recruiting | Sun Yat-sen University | 20 | 2022-01-01 | 2023-11-22 |
| Subantimicrobial Doxycycline in Acne Doxycycline Hyclate - Acne Vulgaris, Pediatrics | Phase 4 | Completed | Michigan State University | 22 | 2020-11-19 | 2023-04-03 |
| MMP-9 Inhibition for Recalcitrant Wet AMD Doxycycline Hyclate, Placebo - Exudative Macular Degeneration, Wet Age-related Macular Degeneration | Phase 2 | Recruiting | University of Iowa | 50 | 2020-11-04 | 2026-04-02 |
| A Study to Compare Efficacy and Safety of Trifarotene Cream When Used With an Oral Antibiotic for the Treatment of Severe Acne Vulgaris (AV) Trifarotene cream, Doxycycline hyclate, Trifarotene Vehicle - Acne Vulgaris | Phase 4 | Completed | Galderma R&D | 202 | 2020-07-29 | 2022-05-10 |
| Doxycycline to Protect Heart Muscle After Heart Attacks Placebo, Doxycycline Hyclate - ST Segment Elevation Myocardial Infarction, Heart Failure | Phase 2 | Completed | University of Alberta | 174 | 2020-01-06 | 2026-04-13 |
| A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Doxycycline, Placebo - Lymphedema, Lymphatic Filariasis | Phase 3 | Completed | The Task Force for Global Health | 235 | 2019-01-15 | 2021-06-24 |
| Doxycycline for Hereditary Hemorrhagic Telangiectasia Doxycycline Hyclate, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 2 | Completed | Unity Health Toronto | 13 | 2018-09-12 | 2025-04-01 |
| A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Doxycycline, Placebo - Lymphedema, Lymphatic Filariasis | Phase 3 | Completed | The Task Force for Global Health | 220 | 2018-06-19 | 2021-06-24 |
| A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Doxycycline, Placebo - Lymphedema, Lymphatic Filariasis | Phase 3 | Completed | The Task Force for Global Health | 219 | 2018-02-16 | 2021-03-17 |
| Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis. Chloroquine, Atovaquone and Proguanil, Doxycycline - Rabies | Phase 4 | Completed | State University of New York - Upstate Medical University | 103 | 2016-11-11 | 2021-05-13 |
| Doxycycline for the Treatment of Nodding Syndrome Doxycycline, Placebo - Seizures | Phase 2 | Unknown | Makerere University | 230 | 2016-09-05 | 2017-02-23 |
| Doxycycline Treatment in Mild Thyroid-Associated Ophthalmopathy Doxycycline hyclate, Placebo - Graves Ophthalmopathy, Graves Disease | Phase 2 | Unknown | Sun Yat-sen University | 100 | 2014-07-01 | 2021-11-17 |
| Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial Doxycycline, Placebo - Aneurysm | Phase 2 | Completed | University of Maryland, Baltimore | 261 | 2013-05-01 | 2021-11-26 |
| Double-blind-randomized,Placebo Controlled Trial for Chemotherapy-associated Oral Mucositis Using Doxycycline Hyclate Doxycycline hyclate - Mucositis | Phase 2 | Unknown | Metropolitan Autonomous University | 164 | 2010-05-01 | 2010-03-16 |
| Treatment of Acne Vulgaris With Doryx Tablets Compared to Doxycyline Hyclate Doxycycline hyclate (Doryx), Doxycycline hyclate - Acne Vulgaris | Phase 4 | Completed | Warner Chilcott | 93 | 2008-03-01 | 2012-04-20 |
Acne Vulgaris (4) · Elephantiasis, Filarial (3) · Filariasis (3) · Lymphedema (3) · Graves Ophthalmopathy (2) · Sexually Transmitted Diseases (2) · Aneurysm (1) · Autoimmune Diseases (1) · Bisexuality (1) · Chlamydia Infections (1) · Endocrine System Diseases (1) · Eye Diseases, Hereditary (1) · Gonorrhea (1) · Graves Disease (1) · Heart Failure (1)
The Task Force for Global Health (3) · Sun Yat-sen University (2) · Galderma R&D (1) · Jonathan Troy Grennan (1) · Makerere University (1) · Massachusetts Eye and Ear Infirmary (1) · Metropolitan Autonomous University (1) · Michigan State University (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · State University of New York - Upstate Medical University (1) · Unity Health Toronto (1) · University of Alberta (1) · University of Iowa (1) · University of Maryland, Baltimore (1) · University of Pennsylvania (1)
United States (8) · Canada (3) · China (2) · Uganda (2) · Botswana (1) · Eswatini (1) · India (1) · Malawi (1) · Mali (1) · Mexico (1) · Puerto Rico (1) · Sri Lanka (1)
Eric Ottesen, MD (3) · Angelo Secci, MD (1) · Benjamin Tyrrell, MD (1) · D. Bradley Welling, MD, PhD (1) · Dan Liang (1) · Dan Liang, MD (1) · Elliott H Sohn, MD (1) · Ian Paterson, MD (1) · John Curci, MD (1) · Jonathan Matsumura, MD (1) · Kevin Bainey, MD (1) · Kevin Marsh, MRCP, DTM&H (1) · Marie E Faughnan, MD MSc FRCPC (1) · Michael L Terrin, MD (1)
PMID 11873261, PMID 22610930, PMID 32228663, PMID 10656038, PMID 29382251, PMID 30841858, PMID 31743394, PMID 32453369, PMID 33595625, PMID 33957227, PMID 34655683, PMID 36173609, PMID 36344987, PMID 38754459, PMID 39066638
R01AG037120 (1), U01AR079752 (1)