8 completed, 1 active not recruiting, 1 terminated. 10 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Completed 8, Active not recruiting 1, Terminated 1 |
| Phase 2 | 4 | Completed 3, Terminated 1 |
Follow DNA methylation analysis: new trials by email Literature Review of DNA methylation analysis trials Research Report on DNA methylation analysis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome flow cytometry, DNA methylation analysis, cytogenetic analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 25 | 2010-07-01 | 2019-03-04 |
| Low-Dose Azacitidine, Lenalidomide, and Low-Dose Dexamethasone in Relapsed or Refractory Multiple Myeloma azacitidine, lenalidomide, dexamethasone - Refractory Multiple Myeloma | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 45 | 2010-06-01 | 2020-11-16 |
| 5-Fluoro-2'-Deoxycytidine and Tetrahydrouridine in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes 5-fluoro-2-deoxycytidine, tetrahydrouridine, laboratory biomarker analysis - Adult Acute Myeloid Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 | Completed | City of Hope Medical Center | 25 | 2009-12-22 | 2026-10-16 |
| ABT-888, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme temozolomide, veliparib, DNA methylation analysis - Brain and Central Nervous System Tumors | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 24 | 2009-07-13 | 2018-06-27 |
| Decitabine, Vaccine Therapy, and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer decitabine, NY-ESO-1 peptide vaccine, pegylated liposomal doxorubicin hydrochloride - Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer | Phase 1 | Completed | Roswell Park Cancer Institute | 18 | 2009-04-01 | 2022-08-01 |
| Clofarabine and Rituximab in Treating Patients With Relapsed Non-Hodgkin Lymphoma rituximab, clofarabine, DNA methylation analysis - Lymphoma | Phase 1 / Phase 2 | Terminated | OHSU Knight Cancer Institute | 2 | 2008-05-01 | 2019-11-27 |
| Genetic Testing in Predicting Biomarkers of Recurrence in Patients With Prostate Cancer Undergoing Surgery DNA analysis, DNA methylation analysis, RNA analysis - Prostate Cancer | Phase 1 | Active not recruiting | City of Hope Medical Center | 1045 | 2007-11-26 | 2026-08-20 |
| Studying Genes in Blood and Lung Fluid Samples From Patients With Chronic Obstructive Pulmonary Disease With or Without a Previous Diagnosis of Lung Cancer or With Asthma Treated With Budesonide and Formoterol budesonide/formoterol fumarate dihydrate inhalation aerosol, DNA methylation analysis, comparative genomic hybridization - Lung Cancer, Precancerous Condition | Phase 1 | Completed | British Columbia Cancer Agency | 30 | 2007-01-01 | 2012-03-09 |
| Decitabine and Tretinoin in Treating Patients With Myelodysplastic Syndromes decitabine, tretinoin, DNA methylation analysis - Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 54 | 2006-07-01 | 2024-05-20 |
| Effect of Folate on DNA in Colon Tissue and Blood Samples From Patients at Increased Risk of Developing Colorectal Neoplasia folic acid, DNA methylation analysis, gene expression analysis - Colorectal Cancer | Phase 1 | Completed | Rockefeller University | 20 | 2003-06-01 | 2009-02-17 |
Myelodysplastic Syndromes (2) · Anemia, Refractory (1) · Anemia, Refractory, with Excess of Blasts (1) · Burkitt Lymphoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Ovarian Epithelial (1) · Central Nervous System Neoplasms (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Fallopian Tube Neoplasms (1) · Glioblastoma (1) · Gliosarcoma (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Leukemia, Myeloid, Acute (1) · Leukemia, Myelomonocytic, Chronic (1)
Case Comprehensive Cancer Center (2) · City of Hope Medical Center (2) · British Columbia Cancer Agency (1) · Memorial Sloan Kettering Cancer Center (1) · OHSU Knight Cancer Institute (1) · Rockefeller University (1) · Roswell Park Cancer Institute (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1)
United States (8) · Canada (1)
Brenda Cooper, MD (1) · Craig Okada, MD, PhD (1) · Ehsan Malek, MD (1) · Frederic Reu (1) · Kunle Odunsi (1) · Larry Kleinberg, MD (1) · Peter R. Holt, MD (1) · Raajit Rampal, MD, PhD (1) · Robert Chen, MD (1) · Stephen Lam, MD (1) · Steven S. Smith, PhD (1) · Yogen Saunthararajah (1)
P30CA033572 (1), P30CA069533 (1), R01CA102521 (1), U01CA062475 (1)