36 completed, 7 unknown, 2 active not recruiting, 1 terminated. 10 Phase 1, 9 Phase 2, 4 Phase 3, 2 Not applicable.
Follow DNA methylation analysis: new trials by email Literature Review of DNA methylation analysis trials Research Report on DNA methylation analysis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Emotional Regulation in Children With ND: the Role of Genomic Variation, Proteomic Patterns, and Early Experience DNA methylation analysis, Proteomics analysis, Still Face Paradigm - Neurodevelopmental Disabilities, Emotional Regulation | Unknown | IRCCS Eugenio Medea | 248 | 2021-04-07 | 2023-10-18 | |
| Studying Genes Using Cord Blood and Placenta Samples From Relatively Healthy Newborns and Samples From Younger Patients With Wilms Tumor DNA methylation analysis, RNA analysis, allele-specific oligonucleotide real-time quantitative polymerase chain reaction - Kidney Cancer | Completed | Children's Oncology Group | 40 | 2012-04-01 | 2016-05-18 | |
| Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer DNA analysis, DNA methylation analysis, RNA analysis - Lung Cancer | Completed | Alliance for Clinical Trials in Oncology | 248 | 2012-03-01 | 2017-06-27 | |
| Studying Genes in Samples From Younger Patients With Adrenocortical Tumor DNA methylation analysis, RNA analysis, gene expression analysis - Adrenocortical Carcinoma | Completed | Children's Oncology Group | 10 | 2012-02-01 | 2016-05-18 | |
| Biomarkers in Predicting Response to Chemotherapy in Patients With Advanced or Metastatic Melanoma Previously Treated With Carboplatin and Paclitaxel With or Without Sorafenib Tosylate DNA methylation analysis, gene expression analysis, laboratory biomarker analysis - Melanoma (Skin) | Completed | ECOG-ACRIN Cancer Research Group | 80 | 2012-01-19 | 2017-05-17 | |
| Bevacizumab and Lomustine for Recurrent GBM bevacizumab, lomustine, DNA methylation analysis - Glioblastoma Multiforme, Cognition Disorders | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 592 | 2011-10-01 | 2021-02-15 |
| Studying Biomarkers in Samples From Younger Patients With Malignant Germ Cell Tumor Progression DNA methylation analysis, RNA analysis, mutation analysis - Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor | Completed | Children's Oncology Group | 90 | 2011-10-01 | 2016-05-18 | |
| Biomarkers in Patients With Rhabdomyosarcoma DNA methylation analysis, fluorescence in situ hybridization, gene expression analysis - Sarcoma | Completed | Children's Oncology Group | 20 | 2011-10-01 | 2016-05-19 | |
| S8600-S9031-S9333-A, Study of DNA in Samples From Patients With Acute Myeloid Leukemia DNA methylation analysis, gene expression analysis, microarray analysis - Leukemia | Completed | SWOG Cancer Research Network | 200 | 2011-10-01 | 2016-04-15 | |
| Biomarkers in Samples From Adult Patients With Acute Myeloid Leukemia Who Failed Existing Standard-of-Care Treatment DNA methylation analysis, RNA analysis, gene expression analysis - Leukemia | Unknown | National Cancer Institute (NCI) | 400 | 2011-09-01 | 2013-07-10 | |
| Biomarker Study of Chemotherapy Resistance and Outcomes in Samples From Older Patients With Acute Myeloid Leukemia DNA methylation analysis, RNA analysis, gene expression analysis - Leukemia | Completed | Eastern Cooperative Oncology Group | 257 | 2011-08-17 | 2017-05-17 | |
| DNA Tests in Detecting Disseminated Disease in Tumor, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma DNA methylation analysis, microarray analysis, polymerase chain reaction - Sarcoma | Completed | Children's Oncology Group | 170 | 2011-08-01 | 2016-05-17 | |
| Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia DNA methylation analysis, gene expression analysis, microarray analysis - Leukemia | Completed | Children's Oncology Group | 32 | 2010-11-01 | 2016-05-19 | |
| Biomarkers in Young Patients With Neuroblastoma DNA analysis, DNA methylation analysis, RNA analysis - Neuroblastoma | Completed | Children's Oncology Group | 380 | 2010-07-01 | 2016-05-18 | |
| Biomarkers in Tissue and Blood Samples From Patients With Early-Stage Non-Small Cell Lung Cancer DNA methylation analysis, polymerase chain reaction, laboratory biomarker analysis - Lung Cancer | Completed | Alliance for Clinical Trials in Oncology | 99 | 2010-07-01 | 2016-07-06 | |
| Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome flow cytometry, DNA methylation analysis, cytogenetic analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 25 | 2010-07-01 | 2019-03-04 |
| Low-Dose Azacitidine, Lenalidomide, and Low-Dose Dexamethasone in Relapsed or Refractory Multiple Myeloma azacitidine, lenalidomide, dexamethasone - Refractory Multiple Myeloma | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 45 | 2010-06-01 | 2020-11-16 |
| Biomarkers in Tissue Samples From Patients With High-Risk Wilms Tumor DNA methylation analysis, gene expression analysis, microarray analysis - Clear Cell Sarcoma of the Kidney, Recurrent Wilms Tumor and Other Childhood Kidney Tumors | Completed | Children's Oncology Group | 185 | 2010-05-01 | 2016-05-19 | |
| Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma bevacizumab, temozolomide, laboratory biomarker analysis - Giant Cell Glioblastoma, Glioblastoma | Phase 2 | Completed | Jonsson Comprehensive Cancer Center | 50 | 2010-04-28 | 2024-09-19 |
| 5-Fluoro-2'-Deoxycytidine and Tetrahydrouridine in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes 5-fluoro-2-deoxycytidine, tetrahydrouridine, laboratory biomarker analysis - Adult Acute Myeloid Leukemia, de Novo Myelodysplastic Syndromes | Phase 1 | Completed | City of Hope Medical Center | 25 | 2009-12-22 | 2026-10-16 |
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Leukemia (10) · Congenital Abnormalities (7) · Leukemia, Myeloid, Acute (7) · Glioblastoma (5) · Carcinoma, Non-Small-Cell Lung (4) · Central Nervous System Neoplasms (4) · Gliosarcoma (4) · Leukemia, Erythroblastic, Acute (4) · Leukemia, Megakaryoblastic, Acute (4) · Leukemia, Monocytic, Acute (4) · Leukemia, Myelomonocytic, Acute (4) · Lung Neoplasms (4) · Myelodysplastic Syndromes (4) · Breast Neoplasms (3) · Colonic Neoplasms (3)
Children's Oncology Group (10) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (4) · Alliance for Clinical Trials in Oncology (3) · ECOG-ACRIN Cancer Research Group (3) · Case Comprehensive Cancer Center (2) · City of Hope Medical Center (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Jonsson Comprehensive Cancer Center (2) · Memorial Sloan Kettering Cancer Center (2) · National Cancer Institute (NCI) (2) · SWOG Cancer Research Network (2) · AIDS Malignancy Consortium (1) · British Columbia Cancer Agency (1) · Canadian Cancer Trials Group (1) · Dr. Susan Love Research Foundation (1)
United States (19) · United Kingdom (5) · Canada (3) · Netherlands (3) · Germany (2) · Italy (2) · Australia (1) · Belgium (1) · France (1) · Israel (1) · Japan (1) · Spain (1) · Switzerland (1)
Alan K. Burnett, MD, FRCP (1) · Alba A. Brandes, MD (1) · Anna Nowak, MD (1) · Anthony Heaney, MD (1) · Antonio C. Wolff, MD (1) · Ari M. Melnick, MD (1) · Brenda Cooper, MD (1) · Caroline Y. Hu, MD (1) · Cheryl L. Willman, MD (1) · Clara Bloomfield, MD (1) · Craig Okada, MD, PhD (1) · Derek L. Stirewalt, MD (1) · Ehsan Malek, MD (1) · Elizabeth J. Perlman, MD (1) · Elizabeth Perlman, MD (1)
PMID 20368434, PMID 20442368, PMID 23032420, PMID 24117272, PMID 24383844, PMID 24386300, PMID 25527568, PMID 25621498, PMID 27744512, PMID 27870562, PMID 28296618, PMID 28801186, PMID 29141164, PMID 31375516, PMID 32632894, PMID 34000245, PMID 34162404, PMID 34847232, PMID 35275197, PMID 36823396, PMID 37196637, PMID 38017103, PMID 38702786, PMID 39283025, PMID 41449147
P30CA006973 (2), U01CA062475 (2), U10CA032102 (2), N01CM62207 (1), P30CA008748 (1), P30CA033572 (1), P30CA069533 (1), R01CA102521 (1), U01CA121947 (1), U10CA098543 (1)