7 completed, 1 active not recruiting, 1 not yet recruiting. 9 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 7, Active not recruiting 1, Not yet recruiting 1 |
| Phase 2 | 1 | Completed 1 |
Follow cytisine: new trials by email Literature Review of cytisine trials Research Report on cytisine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 3 Trial Evaluating the Efficacy and Safety of Cytisinicline for Vaping Cessation in Adults Using Nicotine-Containing E Cigarettes Cytisinicline, Placebo, Behavioral Support - Vaping Cessation | Phase 3 | Not yet recruiting | Achieve Life Sciences | 800 | 2026-05-15 | 2026-02-06 |
| Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers Cytisinicline - Smoking Cessation, Vaping Cessation | Phase 3 | Completed | Achieve Life Sciences | 479 | 2024-05-28 | 2025-11-26 |
| PeRiopEratiVE SmokiNg CessaTion Trial Cytisine, Video Messaging - Smoking (Tobacco) Addiction, Smoking Cessation | Phase 3 | Active not recruiting | Population Health Research Institute | 1720 | 2024-01-15 | 2024-10-03 |
| Cytisine and E-cigarettes With Supportive Text-messaging for Smoking Cessation (Cess@Tion) Cytisine, Nicotine delivered via an e-cigarette, Cytisine plus nicotine delivered via an e-cigarette - Smoking Cessation | Phase 3 | Completed | University of Auckland, New Zealand | 807 | 2022-05-05 | 2024-12-19 |
| A Second Study of Cytisinicline for Smoking Cessation in Adult Smokers Cytisinicline, Placebo, Behavioral support - Smoking Cessation | Phase 3 | Completed | Achieve Life Sciences | 792 | 2022-01-20 | 2026-01-14 |
| A Study of Cytisinicline for Smoking Cessation in Adult Smokers Cytisinicline, Placebo, Behavioral support - Smoking Cessation | Phase 3 | Completed | Achieve Life Sciences | 810 | 2020-10-13 | 2026-01-15 |
| Varenicline Versus Cytisine for Smoking Cessation in Primary Care Setting Varenicline, Cytisine - Smoking Cessation | Phase 3 | Completed | University of Zagreb | 352 | 2020-07-14 | 2022-11-03 |
| Cytisine Versus Varenicline for Smoking Cessation Cytisine, Behavioural support, Varenicline - Smoking Cessation | Phase 3 | Completed | University of Auckland, New Zealand | 679 | 2017-09-18 | 2021-08-19 |
| Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV) Varenicline, Cytisine, Nicotine Replacement Therapy - HIV Infection, Alcohol Use | Phase 2 / Phase 3 | Completed | Boston Medical Center | 400 | 2017-07-19 | 2020-12-17 |
Smoking Cessation (7) · Smoking (2) · Alcohol Drinking (1) · Behavior, Addictive (1) · Coronary Disease (1) · HIV Infections (1) · Inflammation (1) · Tobacco Use (1) · Vaping (1)
Achieve Life Sciences (4) · University of Auckland, New Zealand (2) · Boston Medical Center (1) · Population Health Research Institute (1) · University of Zagreb (1)
United States (3) · New Zealand (2) · Canada (1) · Croatia (1) · Russia (1) · Slovenia (1)
Julie Ball (2) · Natalie Walker, PhD (2) · Daniel Cain, Vice-President Clinical Research (1) · Flavia Kessler Borges, Dr. (1) · Hrvoje Tiljak, PhD (1) · Janez Rifel, PhD (1) · Jeffrey H Samet, MA, MA, MPH (1) · Jeffrey M Ashbruner, PhD, MPH (1) · Nancy Rigotti, MD (1) · Sandra Ofori, Dr. (1) · Sanja Percac Lima, PhD, MD (1) · Stjepan Oreskovic, PhD (1) · Tin Oreskovic (1) · Zalika Klemenc Ketis, MD, PhD (1)
PMID 40962497, PMID 33761149, PMID 35930287, PMID 37432430, PMID 37697327, PMID 40257755
U01AA020780 (1)