6 completed, 3 withdrawn, 2 terminated, 1 active not recruiting. 15 Phase 1, 7 Phase 2.
Follow Cryoablation: new trials by email Literature Review of Cryoablation trials Research Report on Cryoablation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Grouping Immune-modulation With Cryoablation (LOGIC) for Breast Cancers Cryoablation, Cryoablation combined with PD1 Inhibitor - Triple Negative Breast Cancer | Phase 1 / Phase 2 | Not yet recruiting | Texas Tech University Health Sciences Center | 36 | 2026-03-01 | 2025-09-09 |
| A Study of Pembrolizumab and Ablation (Cryoablation or Histotripsy) in People With Breast Cancer Pembrolizumab, Cryoablation, Histotripsy - Metastatic Breast Cancer, Breast Cancer | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 30 | 2024-01-29 | 2026-09-14 |
| Cryotherapy for Locally Advanced Esophageal Cancer Cryotherapy - Esophageal Cancer | Phase 1 | Active not recruiting | Hunter Holmes Mcguire Veteran Affairs Medical Center | 14 | 2020-02-11 | 2026-09-18 |
| Cryoablation Combined With Camrelizumab and Apatinib for Multiprimary Lung Cancer Camrelizumab and Apatinib - Lung Cancer | Phase 1 / Phase 2 | Unknown | ShiYue Li | 20 | 2019-12-01 | 2019-12-17 |
| Dendritic Cell Therapy With Pembrolizumab for Metastatic or Unresectable Melanoma Cryosurgery, Pembrolizumab, Pheresis - Stage III Cutaneous Melanoma AJCC v7, Stage IIIA Cutaneous Melanoma AJCC v7 | Phase 1 / Phase 2 | Terminated | Mayo Clinic | 7 | 2017-11-15 | 2025-06-12 |
| Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma Cryosurgery, Dendritic Cell Therapy, Laboratory Biomarker Analysis - Aggressive Non-Hodgkin Lymphoma, Indolent Non-Hodgkin Lymphoma | Phase 1 / Phase 2 | Completed | Mayo Clinic | 11 | 2017-08-15 | 2026-05-04 |
| Phase-I Trial of Pembrolizumab and Percutaneous Cryoablation Combination Followed by Nephron-Sparing Surgery or Cytoreductive Nephrectomy in Locally Advanced and Metastatic Renal Cell Carcinomas Pembrolizumab Injection [Keytruda], Cryoablation, Nephrectomy - Renal Cell Carcinoma, Metastatic Kidney Cancer | Phase 1 | Withdrawn | University of California, Irvine | 2017-07-01 | 2021-04-05 | |
| Compare Ultrasound Assisted Cold Therapy and Lidocaine Injection to Treat Morton's Neuroma Cryoablation, Lidocaine, Saline - Intermetatarsal Neuroma | Phase 1 | Completed | Icahn School of Medicine at Mount Sinai | 10 | 2016-07-01 | 2018-11-06 |
| Increased Frequency of AlloStim(TM) Dosing in Combination With Cryoablation in Metastatic Breast Cancer Patients AlloStim, Cryoablation - Metastatic Breast Cancer | Phase 1 / Phase 2 | Withdrawn | Mirror Biologics, Inc. | 2014-03-01 | 2020-01-22 | |
| Tremelimumab With Chemoembolization or Ablation for Liver Cancer Tremelimumab, RFA, TACE - Heptocellular Cancer, Biliary Tract Neoplasms | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 61 | 2013-05-02 | 2019-12-10 |
| Safety and Efficacy of Cryoablation Combined With Radiation Therapy for the Palliation of Painful Bone Metastases Cryoablation, Radiation - Pain, Neoplasm Metastasis | Phase 1 | Withdrawn | Boston Scientific Corporation | 2013-04-01 | 2021-07-16 | |
| Pre-Operative, Single-Dose Ipilimumab and/or Cryoablation in Early Stage/Resectable Breast Cancer Cryoablation, Ipilimumab - Breast Cancer, Invasive Adenocarcinoma of the Breast | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 19 | 2011-12-01 | 2016-01-05 |
| Safety and Efficacy of Cryoablation for the Palliation of Painful Bone Metastases Cryoablation - Pain, Neoplasm Metastasis | Phase 1 | Completed | Boston Scientific Corporation | 29 | 2011-11-01 | 2021-07-16 |
| Safety and Efficacy of Cryoablation for Abdominal Pain Associated With Pancreatic Cancer Cryoablation - Pain, Pancreatic Cancer | Phase 1 | Terminated | Boston Scientific Corporation | 14 | 2011-08-01 | 2021-07-16 |
| Experimental Therapeutic Cancer Vaccine Created In-situ in Patients With Stage II-Stage IV Cancer AlloStim, Cryoablation - Solid Tumors Stage II, Stage III and Stage IV, Breast Cancer | Phase 1 / Phase 2 | Completed | Michael Har-Noy | 9 | 2010-12-01 | 2020-01-22 |
Breast Neoplasms (4) · Pain (3) · Bone Neoplasms (2) · Carcinoma, Renal Cell (2) · Melanoma (2) · Neoplasm Metastasis (2) · Triple Negative Breast Neoplasms (2) · Abdominal Pain (1) · Biliary Tract Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1) · Esophageal Neoplasms (1) · Gastrointestinal Neoplasms (1) · Kidney Neoplasms (1)
Boston Scientific Corporation (3) · Mayo Clinic (2) · Memorial Sloan Kettering Cancer Center (2) · Hunter Holmes Mcguire Veteran Affairs Medical Center (1) · Icahn School of Medicine at Mount Sinai (1) · Michael Har-Noy (1) · Mirror Biologics, Inc. (1) · National Cancer Institute (NCI) (1) · ShiYue Li (1) · Texas Tech University Health Sciences Center (1) · University of California, Irvine (1)
United States (11) · Canada (1) · France (1) · Israel (1)
Jerry Matteo, MD (2) · David D Childs, MD (1) · David Spinner, DO (1) · Dr. Michael Har-Noy (1) · Heather McArthur, MD, MPH (1) · Jaime Landman, MD (1) · Matthew S. Block, M.D., Ph.D. (1) · Tamar Peretz, MD (1) · Tilak Shah, MD (1) · Tim F Greten, M.D. (1) · Yi Lin, MD, PhD (1) · Yolanda Bryce, MD (1) · Zivile Katiliene, Ph.D. (1)
PMID 18054441, PMID 18565579, PMID 18834631, PMID 21123824, PMID 22075702, PMID 27816492, PMID 28923358, PMID 30578687, PMID 30688989
P50CA097274 (1), R01CA219960 (1)