46 completed, 11 recruiting, 8 unknown, 7 not yet recruiting. 55 Not applicable, 10 Phase 2, 9 Phase 3, 6 Phase 4, 3 Early Phase 1.
Follow Creatine monohydrate: new trials by email Literature Review of Creatine monohydrate trials Research Report on Creatine monohydrate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Creatine and Perioperative Brain Health Creatine monohydrate, Placebo - Neurocognitive Disorders, Postoperative Delirium | Not applicable | Not yet recruiting | Massachusetts General Hospital | 120 | 2026-11-01 | 2026-10-27 |
| Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease Creatine monohydrate, Beta-hydroxy-beta-methylbutyrate (HMB), Placebo (microcrystalline cellulose) - Huntington Disease, Sarcopenia | Not applicable | Not yet recruiting | Universidad de Burgos | 88 | 2026-11-01 | 2026-10-28 |
| Creatine Supplementation in Pediatric Brain Injury Creatine monohydrate, Microcrystalline Cellulose - Brain Injury, Traumatic Brain Injury | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 46 | 2026-10-01 | 2026-08-10 |
| The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults Tyrosol, Creatine Monohydrate, Resistant Dextrin - Tyrosol, Creatine | Not applicable | Recruiting | Applied Science & Performance Institute | 60 | 2026-09-04 | 2026-09-21 |
| Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution Creatine Monohydrate, Maltodextrin (Placebo) - Heat Exposure, Exercise Performance | Not applicable | Not yet recruiting | University of Windsor | 25 | 2026-07-30 | 2026-05-18 |
| Effects of Creatine and Carbohydrate Supplementation on Endurance Performance Creatine Monohydrate, Carbohydrate, Creatine Monohydrate and Carbohydrate - Exercise Performance Recovery | Not applicable | Not yet recruiting | California Polytechnic State University-San Luis Obispo | 12 | 2026-07-15 | 2026-07-21 |
| Creatine Supplementation and Resistance Training to Improve Sarcopenia Parameters in Patients With Prostate Cancer After Androgen Deprivation Therapy Creatine Monohydrate, Maltodextrin, Resistance training - Prostate Cancer, Sarcopenia | Not applicable | Recruiting | University of Sao Paulo | 34 | 2026-05-01 | 2026-06-11 |
| Creatine Supplementation for Improved Voice Performance in the Elderly Creatine monohydrate, Placebo - Presbyphonia | Not applicable | Suspended | NYU Langone Health | 20 | 2026-05-01 | 2026-03-04 |
| Dietary Supplements and Middle Aged Women (Creatine) Creatine Monohydrate, Placebo control - Cognition, Muscle Strength | Not applicable | Recruiting | Loughborough University | 38 | 2026-05-01 | 2026-07-28 |
| Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat Creatine Monohydrate, Maltodextrin (Placebo) - Acute Kidney Injury, Exertional Heat Illness | Not applicable | Recruiting | University of Northern Iowa | 20 | 2026-03-12 | 2026-03-16 |
| Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Muscle Function in Sarcopenic Frailty Placebo (Cellulose), Creatine Monohydrate, Multicomponent Exercise Program - Frailty, Sarcopenia | Not applicable | Active not recruiting | Universidad de Burgos | 50 | 2026-03-10 | 2026-05-04 |
| Effects of Short-term Acute Creatine Supplementation on Power, Speed and Muscular Strengths in Young Football Players Creatine Monohydrate, Placebo - Performance Enhancement | Not applicable | Not yet recruiting | St. Mary's University, Twickenham | 20 | 2026-03-01 | 2026-03-16 |
| Antioxidant Supplementation and Muscle Recovery From DOMS in Trained Women Creatine Monohydrate, Omega 3 FA (Fish Oil), N-Acetyl Cysteine (NAC) - Delayed Onset Muscle Soreness, Exercise-induced Muscle Damage | Not applicable | Completed | Antonio Molina Lopez | 60 | 2026-02-19 | 2026-10-16 |
| Effects of 7-Day Creatine Supplementation on Cognitive Function After High-Intensity Interval Training in Active Young Men Creatine Monohydrate, Placebo, High Intensity Interval Training - Creatine Supplementation, Exercise Ergogenics | Not applicable | Completed | Universitas Negeri Malang | 20 | 2026-02-07 | 2026-04-16 |
| Effects of Soy Protein and Creatine Supplementation on Certain Parameters in Men Performing Resistance Exercise soy protein, Creatine Monohydrate - Healthy Men Doing Resistance Training | Not applicable | Completed | Yakup Enes Çam | 54 | 2026-01-05 | 2026-07-30 |
| Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment Creatine monohydrate, Resistance training - Creatine, Exercise | Not applicable | Recruiting | Western University, Canada | 140 | 2026-01-01 | 2026-08-20 |
| Impact of OptiCreatine on Plasma Creatine and Gastrointestinal Effects in Males and Females OptiCreatine, Creatine Monohydrate - Creatine Absorption in Healthy Adults | Not applicable | Completed | TSI Group LTD | 17 | 2025-11-05 | 2026-03-12 |
| PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS) Sleep and dietary counseling, Supervised exercise and exergaming program, Motivational interviewing - Ageing | Not applicable | Recruiting | National University of Singapore | 20 | 2025-09-29 | 2026-03-05 |
| Load and Hold: Impact of 7-Day Creatine Monohydrate Loading on Breath-Hold Cycling Performance Creatine Monohydrate, Placebo Control - Healthy | Not applicable | Enrolling by invitation | Harokopio University | 26 | 2025-07-24 | 2025-11-18 |
| Exploring the Therapeutic Effects of Creatine Supplementation for Long COVID-19 Creatine monohydrate - Long COVID Fatigue | Not applicable | Not yet recruiting | University of Calgary | 24 | 2025-07-02 | 2025-05-31 |
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Depression (7) · Depressive Disorder, Major (7) · Sarcopenia (7) · Huntington Disease (6) · Motor Activity (5) · Fatigue (3) · Prostatic Neoplasms (3) · Stroke (3) · Substance-Related Disorders (3) · Acute Kidney Injury (2) · Amyotrophic Lateral Sclerosis (2) · Brain Concussion (2) · Disease (2) · Frailty (2) · Muscular Dystrophy, Duchenne (2)
Massachusetts General Hospital (6) · University of Utah (6) · Perry Renshaw (4) · University of Regina (4) · Florida State University (3) · University of Saskatchewan (3) · Applied Science & Performance Institute (2) · Texas A&M University (2) · Universidad de Burgos (2) · University of Northern Iowa (2) · University of Sao Paulo (2) · Alliance for Clinical Trials in Oncology (1) · Ankara Yildirim Beyazıt University (1) · Antonio Molina Lopez (1) · Bangor University (1)
United States (43) · Canada (10) · Spain (5) · United Kingdom (3) · Australia (2) · Brazil (2) · Denmark (2) · Turkey (Türkiye) (2) · Austria (1) · Colombia (1) · Greece (1) · Indonesia (1) · Iran (1) · Israel (1) · Netherlands (1)
Diana Rosas, MD, MS (4) · Perry Renshaw, MD, PhD, MBA (3) · Steven M Hersch, MD, PhD (3) · Darren Candow, Ph.D. (2) · Darren G Candow, PhD (2) · Perry F Renshaw, MD, PhD, MBA (2) · Philip Chilibeck, Ph.D. (2) · Aaron Johnson (1) · Abbie Smith-Ryan, PhD (1) · Adriana Coletta (1) · Adriana Coletta, PhD, MS, RD (1) · Aminah Jatoi, MD (1) · Andres Rojas-Jaramillo, PhD (1) · Andrew Jagim, PhD (1) · Beny Lafer, PhD (1)
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P01NS058793 (1), P30CA042014 (1), R01CA281759 (1), U01AT000613 (1), UL1TR001082 (1)