11 completed, 3 terminated, 2 unknown, 1 recruiting. 7 Phase 3, 5 Phase 4, 3 Phase 2, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 7 | Completed 4, Terminated 2, Recruiting 1 |
| Phase 4 | 5 | Completed 4, Unknown 1 |
| Phase 2 | 3 | Completed 1, Terminated 1, Unknown 1 |
| Not applicable | 2 | Completed 2 |
Follow cotrimoxazole: new trials by email Literature Review of cotrimoxazole trials Research Report on cotrimoxazole
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Cotrimoxazole as a De-escalation Treatment of Ventilator-Associated Pneumonia in Intensive Care Unit cotrimoxazole, standard antibiotic therapy - Ventilator Associated Pneumonia | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 628 | 2023-10-19 | 2025-05-20 |
| Administration of Antibiotic Prophylaxis for Transperineal Prostate Biopsy in Cipto Mangunkusumo Hospital Cotrimoxazole, Placebo - Prostate Cancer, Prostate Biopsy | Phase 2 | Unknown | Universitas Indonesia | 78 | 2021-07-06 | 2021-08-05 |
| Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy Clindamycin, Diary, Ertapenem - Bladder Carcinoma, Refractory Bladder Carcinoma | Phase 4 | Completed | Roswell Park Cancer Institute | 89 | 2020-09-02 | 2026-09-29 |
| A Novel Regimen to Prevent Malaria and STI in Pregnant Women With HIV Azithromycin/TMPS, Placebo/TMPS - HIV, Pregnancy Malaria | Phase 2 | Completed | University of Alabama at Birmingham | 308 | 2018-03-07 | 2023-11-27 |
| Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso Azithromycin, Amoxicillin, Cotrimoxazole - Child Development | Phase 4 | Completed | University of California, San Francisco | 252 | 2017-07-04 | 2023-03-02 |
| Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria Cotrimoxazole, Placebo - HIV-1-infection, Pneumocystis Pneumonia | Phase 4 | Completed | University of Bergen | 537 | 2017-03-30 | 2019-10-02 |
| Study to Test the Validity of the Treatment of Idiopathic Pulmonary Fibrosis With Cotrimoxazole Cotrimoxazole, Placebo - Idiopathic Pulmonary Fibrosis | Phase 3 | Terminated | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 3 | 2013-11-25 | 2017-11-14 |
| Discontinuation of Trimethoprim-sulfamethoxazole Prophylaxis in Adults on Antiretroviral Therapy in Kenya Discontinue TMP/SMZ prophylaxis - HIV Infections, Acquired Immunodeficiency Syndrome | Not applicable | Completed | University of Washington | 500 | 2012-02-01 | 2014-04-11 |
| VSL#3 and Spontaneous Bacterial Peritonitis cotrimoxazole, VSL#3 active, VSL#3 placebo - Decompensated Cirrhosis, Ascites | Phase 2 | Terminated | Nottingham University Hospitals NHS Trust | 10 | 2012-02-01 | 2016-10-28 |
| Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine cotrimoxazole, mefloquine - Malaria in Pregnancy, HIV Infections | Phase 3 | Completed | Institut de Recherche pour le Developpement | 430 | 2009-12-01 | 2013-01-23 |
| Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy Cotrimoxazole, Sulfadoxine-pyrimethamine - Malaria in Pregnancy | Phase 3 | Terminated | Institute of Tropical Medicine, Belgium | 352 | 2009-02-01 | 2016-01-18 |
| Safety of Cotrimoxazole in HIV- and HAART-exposed Infants cotrimoxazole - Acquired Immunodeficiency Syndrome, Infant, Newborn | Phase 4 | Completed | Harvard School of Public Health (HSPH) | 222 | 2009-02-01 | 2011-02-25 |
| Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda cotrimoxazole, Placebo - HIV Infections | Phase 4 | Unknown | MRC/UVRI and LSHTM Uganda Research Unit | 1650 | 2008-06-01 | 2008-06-05 |
| Cotrimoxazole Versus Amoxicillin in the Treatment of Community Acquired Pneumonia in Children Aged 2-59 Months Amoxicillin, Cotrimoxazole, Amoxicillin placebo - Childhood Pneumonia | Phase 3 | Completed | Makerere University | 505 | 2007-07-01 | 2009-07-07 |
| Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections Cotrimoxazole, Vancomycin - Staphylococcal Infections, Meningitis | Phase 3 | Completed | Rabin Medical Center | 252 | 2007-06-01 | 2015-09-25 |
| Antibiotics for the Treatment of Ulcerative Colitis Cefuroxime, Ciprofloxacin, Clarithromycin - Colitis, Ulcerative | Not applicable | Completed | University of Dundee | 40 | 2006-07-01 | 2009-02-11 |
| Isoniazid Prophylaxis With Concomitant Cotrimoxazole in HIV-infected Children Isoniazid, Cotrimoxazole, isoniazid - Tuberculosis | Phase 3 | Completed | University of Cape Town | 450 | 2003-01-01 | 2019-04-22 |
HIV Infections (4) · Acquired Immunodeficiency Syndrome (3) · Malaria (3) · Pneumonia (3) · Infections (2) · Opportunistic Infections (2) · Pneumonia, Ventilator-Associated (2) · Sepsis (2) · Urinary Tract Infections (2) · Anemia (1) · Ascites (1) · Bacteriuria (1) · Catheter-Related Infections (1) · Coinfection (1) · Colitis, Ulcerative (1)
Assistance Publique - Hôpitaux de Paris (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Harvard School of Public Health (HSPH) (1) · Institut de Recherche pour le Developpement (1) · Institute of Tropical Medicine, Belgium (1) · MRC/UVRI and LSHTM Uganda Research Unit (1) · Makerere University (1) · Nottingham University Hospitals NHS Trust (1) · Rabin Medical Center (1) · Roswell Park Cancer Institute (1) · Universitas Indonesia (1) · University of Alabama at Birmingham (1) · University of Bergen (1) · University of California, San Francisco (1) · University of Cape Town (1)
United States (3) · Uganda (2) · United Kingdom (2) · Benin (1) · Botswana (1) · Burkina Faso (1) · France (1) · Indonesia (1) · Israel (1) · Kenya (1) · South Africa (1) · Spain (1) · Tanzania (1) · Zambia (1)
Catherine E Oldenburg, ScD (1) · Christina Polyak, MD, MPH (1) · Christine Manyando, MD (1) · Dyandra Parikesit, B.Med.Sc., M.D. (1) · George Miiro, MSc, MBChB (1) · George T Macfarlane, BSCc, PHD (1) · Harun Wijanarko Kusuma Putra, M.D, B.Med.Sci(Hons) (1) · Heather J Zar, MD PHd (1) · Heiner Grosskurth, PhD, MD (1) · Hendy Mirza, M.D. (1) · Jihad Bishara, MD (1) · Jodie A Dionne-Odom, MD (1) · Joel Manyahi, MD (1)
PMID 39324693, PMID 10218526, PMID 10219064, PMID 11172138, PMID 11188837, PMID 12594647, PMID 15577626, PMID 16371882, PMID 17085459, PMID 19886982, PMID 21460373, PMID 24086319, PMID 24670570, PMID 24830749, PMID 24903787, PMID 24996807, PMID 25977146, PMID 26731191, PMID 28077587, PMID 30014828, PMID 30515431, PMID 30895203, PMID 30897090, PMID 31362969, PMID 32556194, PMID 32653726, PMID 33586013, PMID 36803640, PMID 40279497
P30AI060354 (1), R24TW007988 (1)