14 completed, 2 terminated, 1 unknown. 8 Phase 3, 7 Phase 2, 1 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 8 |
| Phase 2 | 7 | Completed 5, Terminated 2 |
| Not applicable | 1 | Completed 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Caspofungin Acetate: new trials by email Literature Review of Caspofungin Acetate trials Research Report on Caspofungin Acetate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| To Evaluate the Efficacy and Safety of Micafungin in Preventing Invasive Mycosis After Liver Transplantation Micafungin Sodium 50 MG Injection, Caspofungin Acetate - Liver Transplantation | Phase 4 | Unknown | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 200 | 2022-10-01 | 2022-08-16 |
| Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant Caspofungin Acetate, Fluconazole, Laboratory Biomarker Analysis - Fungal Infection, Hematopoietic and Lymphoid Cell Neoplasm | Phase 3 | Completed | Children's Oncology Group | 292 | 2013-03-21 | 2024-10-16 |
| Empirical Versus Preemptive Antifungal Therapy caspofungin acetate - Fungal Infection, Leukemia | Phase 3 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 556 | 2012-03-01 | 2023-12-11 |
| Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Caspofungin Acetate, Fluconazole, Laboratory Biomarker Analysis - Acute Myeloid Leukemia, Adult Acute Monoblastic Leukemia | Phase 3 | Completed | Children's Oncology Group | 517 | 2011-04-04 | 2021-03-30 |
| Pilot Feasibility Study With Patients Who Are at High Risk For Developing Invasive Candidiasis in a Critical Care Setting (MK-0991-067) Caspofungin acetate, Placebo - Invasive Candidiasis | Phase 2 | Terminated | Merck Sharp & Dohme LLC | 15 | 2010-12-01 | 2017-03-24 |
| A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED) caspofungin acetate, Comparator: Micafungin sodium - Fungal Infection | Phase 3 | Completed | Merck Sharp & Dohme LLC | 121 | 2008-08-01 | 2017-03-23 |
| A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults (MK-0991-066) caspofungin acetate - Fungal Infection | Phase 3 | Completed | Merck Sharp & Dohme LLC | 63 | 2008-01-01 | 2017-03-24 |
| Open, Pharmacokinetic Study of Caspofungin in Neonates and Infants (0991-058) caspofungin acetate - Candidiasis | Phase 2 | Completed | Merck Sharp & Dohme LLC | 16 | 2006-05-01 | 2017-02-23 |
| A Multicenter, Randomized, Double-Blind, Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of 2 Dosing Regimens of an Antifungal Drug in the Treatment of Fungal Infections in Adults (0991-801)(COMPLETED) caspofungin acetate - Invasive Candidiasis | Phase 3 | Completed | Merck Sharp & Dohme LLC | 204 | 2006-01-01 | 2017-03-24 |
| A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED) caspofungin acetate - Fungal Infection | Phase 3 | Completed | Merck Sharp & Dohme LLC | 50 | 2005-06-01 | 2017-02-23 |
| Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant caspofungin acetate - Cancer | Phase 2 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 171 | 2005-02-01 | 2012-09-24 |
| Open, Pharmacokinetic Study of Caspofungin Acetate in Immunocompromised Young Children With Febrile Neutropenia (0991-042) caspofungin acetate - Fungal Infection | Phase 2 | Completed | Merck Sharp & Dohme LLC | 16 | 2004-05-01 | 2017-02-23 |
| Documented Candida or Aspergillus Infections in Pediatric Patients (0991-043) caspofungin acetate - Aspergillosis, Candidiasis | Phase 2 | Completed | Merck Sharp & Dohme LLC | 50 | 2004-04-01 | 2017-02-23 |
| MK0991 Versus Amphotericin B for Empirical Therapy in Febrile, Neutropenic Pediatric Patients (0991-044) caspofungin acetate, Comparator: AmBisome - Neutropenia, Fever | Phase 2 | Completed | Merck Sharp & Dohme LLC | 100 | 2004-04-01 | 2017-02-23 |
| Voriconazole and Caspofungin Acetate in Treating Invasive Fungal Infections in Patients With Weakened Immune Systems caspofungin acetate, voriconazole - Infection, Unspecified Adult Solid Tumor, Protocol Specific | Phase 2 | Terminated | OHSU Knight Cancer Institute | 13 | 2003-08-01 | 2025-04-27 |
| Caspofungin Acetate in Treating Children With Fever and Neutropenia caspofungin acetate - Fever, Sweats, and Hot Flashes, Infection | Not applicable | Completed | National Cancer Institute (NCI) | 2001-03-01 | 2013-06-19 | |
| Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment caspofungin acetate, liposomal amphotericin B - Cancer | Phase 3 | Completed | Memorial Sloan Kettering Cancer Center | 2000-08-01 | 2013-01-18 |
Mycoses (8) · Infections (4) · Leukemia, Myeloid, Acute (4) · Neutropenia (4) · Burkitt Lymphoma (3) · Candidiasis (3) · Fever (3) · Leukemia (3) · Neuroblastoma (3) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (3) · Blast Crisis (2) · Breast Neoplasms (2) · Candidiasis, Invasive (2) · Carcinoma, Ovarian Epithelial (2) · Congenital Abnormalities (2)
Merck Sharp & Dohme LLC (9) · Children's Oncology Group (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Memorial Sloan Kettering Cancer Center (1) · National Cancer Institute (NCI) (1) · OHSU Knight Cancer Institute (1) · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (1)
United States (5) · Belgium (2) · Canada (2) · France (2) · Germany (2) · Slovakia (2) · Czechia (1) · Italy (1) · Netherlands (1) · Puerto Rico (1) · Switzerland (1) · Turkey (Türkiye) (1)
Christopher C Dvorak (1) · Claudio Viscoli, MD (1) · Kent Sepkowitz, MD (1) · Lynne Strasfeld, MD (1) · Theoklis E Zaoutis (1) · Thomas J. Walsh, MD (1)
PMID 15459300, PMID 19841031, PMID 20431381, PMID 23052987, PMID 31688884, PMID 33136159, PMID 35906831
U10CA095861 (2), UG1CA189955 (2)