8 completed, 2 unknown, 1 active not recruiting, 1 recruiting. 5 Phase 4, 3 Phase 2, 2 Not applicable, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 5 | Completed 3, Recruiting 1, Unknown 1 |
| Phase 2 | 3 | Completed 2, Active not recruiting 1 |
| Not applicable | 2 | Completed 2 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow benphothiamine: new trials by email Literature Review of benphothiamine trials Research Report on benphothiamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Benfotiamine Versus Vitamin B1-6-12 for Diabetic Peripheral Neuropathy Benfotiamine, Vitamin B1-6-12 - Diabetic Peripheral Neuropathy (DPN) | Phase 4 | Recruiting | Thammasat University | 66 | 2026-07-14 | 2026-07-21 |
| A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam) Low Dose Benfotiamine, High Dose Benfotiamine, Placebo - Alzheimer Disease | Phase 2 | Active not recruiting | Weill Medical College of Cornell University | 406 | 2024-03-28 | 2026-09-17 |
| Benfotiamine Effect on Advanced Glycation End Products(AGEs) and Soluble Receptor for AGEs(sRAGE) in Diabetes Mellitus. Benfotiamine, Placebo - Type 2 Diabetes Mellitus | Not applicable | Completed | Universidad de Guanajuato | 41 | 2015-10-01 | 2017-06-07 |
| Benfotiamine in Alzheimer's Disease: A Pilot Study Benfotiamine - Alzheimer's Disease | Phase 2 | Completed | Burke Medical Research Institute | 71 | 2015-02-15 | 2022-06-28 |
| Effects of Benfotiamine on Intraepidermal Nerve Fiber Density (IENFD) Benfotiamine, Placebo for benfotiamine - Diabetic Neuropathies | Phase 3 | Unknown | Diabetes Schwerpunktpraxis | 22 | 2013-07-01 | 2013-06-04 |
| High Dose Vitamin B1 to Reduce Abusive Alcohol Use Benfotiamine, Placebo - Alcoholism | Phase 4 | Completed | University of Kansas | 120 | 2008-07-01 | 2014-09-25 |
| Benfotiamine Prevents Vascular Dysfunction in Healthy Smokers Benfotiamine - Healthy Subjects | Phase 3 | Completed | Ruhr University of Bochum | 20 | 2008-01-01 | 2008-11-05 |
| Benfotiamine in Diabetic Nephropathy Benfotiamine, Placebo - Diabetic Nephropathy | Phase 4 | Completed | University Medical Center Groningen | 86 | 2007-12-01 | 2009-11-16 |
| Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Benfotiamine, Placebo - Diabetes Mellitus, Type 2 | Phase 4 | Unknown | Ruhr University of Bochum | 30 | 2007-09-01 | 2007-09-27 |
| Effects of Vitamin B1 in Type 1 Diabetic Patients Placebo, Benfotiamine - Diabetes Mellitus, Type 1 | Phase 1 / Phase 2 | Completed | University Hospital, Aker | 67 | 2005-08-01 | 2013-05-10 |
| Reactive Oxygen Species in the Pathogenesis of Diabetic Complications benfotiamine, α-lipoic acid - Type 1 Diabetes | Not applicable | Completed | Albert Einstein College of Medicine | 21 | 2005-02-01 | 2019-11-12 |
| Effects of Benfotiamine and AGE on Endothelial Function in People With Diabetes Benfotiamine 1050mg, 3 days, high-AGE vs. low-AGE meal - Endothelial Dysfunction, Type 2 Diabetes Mellitus | Phase 4 | Completed | Ruhr University of Bochum | 21 | 2004-11-01 | 2007-02-19 |
Diabetes Mellitus (3) · Diabetes Mellitus, Type 2 (3) · Alzheimer Disease (2) · Diabetes Complications (2) · Diabetes Mellitus, Type 1 (2) · Alcoholism (1) · Cognitive Dysfunction (1) · Diabetic Nephropathies (1) · Diabetic Neuropathies (1) · Hyperglycemia (1) · Kidney Diseases (1)
Ruhr University of Bochum (3) · Albert Einstein College of Medicine (1) · Burke Medical Research Institute (1) · Diabetes Schwerpunktpraxis (1) · Thammasat University (1) · Universidad de Guanajuato (1) · University Hospital, Aker (1) · University Medical Center Groningen (1) · University of Kansas (1) · Weill Medical College of Cornell University (1)
Germany (4) · United States (4) · Mexico (1) · Netherlands (1) · Norway (1) · Thailand (1)
Alin O Stirban, Dr (1) · Alin O Stirban, MD, PhD (1) · Alin O Stirban, PhD (1) · Alin Stirban, MD (1) · Ann Manzardo, PhD (1) · Diethelm Tschoepe, Prof.PhD. (1) · G J Navis, MD, PhD (1) · Gary E Gibson, Ph.D. (1) · Gary E. Gibson, PhD (1) · H JG Bilo, MD, PhD (1) · Howard Feldman, MDCM (1) · Jose A. Luchsinger, MD MPH (1) · Kristian F Hanssen, MD, PhD (1) · Ma. Eugenia Garay-Sevilla, MD (1) · Michael Brownlee, M.D. (1)
PMID 18663426, PMID 20413516, PMID 22446172, PMID 22792314, PMID 25908323, PMID 33074237, PMID 38809849
R01AG043679 (1), R01AG076634 (1)