16 completed, 5 terminated, 3 recruiting, 2 active not recruiting. 31 Phase 1, 17 Phase 2.
Follow ATG: new trials by email Literature Review of ATG trials Research Report on ATG
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sirolimus+Ruxolitinib+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to CNI Sirolimus, Ruxolitinib, MMF - Acute Leukemia, Myelodysplastic Syndromes | Phase 1 / Phase 2 | Not yet recruiting | Peking University People's Hospital | 40 | 2026-10-01 | 2026-09-09 |
| Phase 1b/2a Trial of Allogeneic HSCT From an HLA-partially Matched Related or Unrelated Donor After TCRab+ T-cell/CD19+ B-cell Depletion for Patients With Monogenic and/or Early-onset Medically Refractory Crohn Disease CliniMACS® TCR α/β Reagent Kit and CliniMACS® CD19 System, Prednisone/Methylprenisolone, Palifermin - Crohn Disease | Phase 1 / Phase 2 | Not yet recruiting | Stanford University | 14 | 2025-07-01 | 2025-05-23 |
| A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia Anti-Thymocyte Globulin, Biospecimen Collection, Bone Marrow Aspirate - Recurrent Severe Aplastic Anemia, Refractory Severe Aplastic Anemia | Phase 1 | Recruiting | City of Hope Medical Center | 6 | 2024-11-15 | 2026-01-05 |
| Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin Inhibitors Sirolimus, Abatacept, MMF - Acute Leukemia, Myelodysplastic Syndromes | Phase 1 / Phase 2 | Unknown | Peking University People's Hospital | 6 | 2024-03-01 | 2024-03-21 |
| Early Trial of Allogeneic Hematopoietic Stem Cell Transplantation for Patients Who Will Receive a Kidney Transplant From the Same Donor Cyclophosphamide 1200 mg/Kg, Fludarabine, Cyclophosphamide 100 mg/Kg - SIOD, Cystinosis | Phase 1 / Phase 2 | Recruiting | Alice Bertaina | 12 | 2023-01-10 | 2023-07-17 |
| Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant Anti-Thymocyte Globulin, Cyclophosphamide, Cytokine-treated Veto Cells - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 16 | 2019-08-08 | 2026-06-11 |
| T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic Anemia Antithymocyte globulin (Rabbit), fludarabine, total body irradiation - Myeloid Diseases | Phase 1 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 17 | 2018-05-09 | 2026-07-24 |
| Romidepsin Maintenance After Allogeneic Stem Cell Transplantation Romidepsin, Busulfan, Fludarabine - Cutaneous T-cell Lymphoma, T-Prolymphocytic Leukemia | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 23 | 2017-12-08 | 2025-09-19 |
| Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies radiation therapy, cyclophosphamide, anti-thymocyte globulin - Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission | Phase 1 | Completed | Sumithira Vasu | 33 | 2015-07-27 | 2023-09-21 |
| Renal Allograft Tolerance Through Mixed Chimerism (Belatacept) Belatacept, ATG, Rituximab - Kidney Failure, Chronic, Renal Insufficiency | Phase 1 | Completed | Massachusetts General Hospital | 2 | 2015-02-01 | 2021-10-25 |
| Safety and Efficacy of Patient's Own AD-MSC and AD-HSC Transplantation in Patients With Severe Aplastic Anemia Rabbit antithymoglobulin (ATG), Adipose derived mesenchymal stem cells ( AD-MSCs), AD-MSC transdifferentiated HSCs (AD-HSCs) - Severe Aplastic Anemia | Phase 1 / Phase 2 | Unknown | Navy General Hospital, Beijing | 90 | 2015-01-01 | 2015-04-03 |
| Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies total marrow irradiation, fludarabine phosphate, busulfan - Acute Myeloid Leukemia, Hematologic Malignancies | Phase 1 | Completed | Case Comprehensive Cancer Center | 14 | 2014-11-05 | 2021-05-07 |
| Fludarabine Phosphate, Clofarabine, and Busulfan With Vorinostat in Treating Patients With Acute Leukemia in Remission or Relapse Undergoing Donor Stem Cell Transplant Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Anti-Thymocyte Globulin - Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission | Phase 1 | Completed | M.D. Anderson Cancer Center | 70 | 2014-03-06 | 2022-01-06 |
| Study To Examine Toxicity Of Allogeneic Stem Cell Transplantation For Relapsed Or Therapy Refractory Ewings Sarcoma Rabbit anti-thymocyte globulin, Busulfan, Melphalan - EWINGS SARCOMA | Phase 1 | Completed | University of Louisville | 10 | 2013-04-01 | 2017-05-09 |
| Allogeneic Stem Cell Transplant for CLL Allogeneic Hematopoietic Stem Cell Transplantation, Anti-Thymocyte Globulin, Busulfan - Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 15 | 2012-11-21 | 2020-02-24 |
| CMC-544 and Allogeneic Transplantation for CD22 Positive-Lymphoid Malignancies Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Anti-Thymocyte Globulin - Hematopoietic and Lymphoid Cell Neoplasm | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 27 | 2012-10-29 | 2024-07-23 |
| Gemcitabine Hydrochloride, Clofarabine, and Busulfan Before Donor Stem Cell Transplant in Treating Patients With Refractory B-Cell or T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Anti-Thymocyte Globulin - Hematopoietic Cell Transplantation Recipient, Refractory B-Cell Non-Hodgkin Lymphoma | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 64 | 2012-10-25 | 2025-02-28 |
| Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies Melphalan, Fludarabine, Mycophenolate mofetil - Blood And Marrow Transplantation, Leukemia | Phase 1 | Completed | M.D. Anderson Cancer Center | 33 | 2012-07-13 | 2017-04-28 |
| Autologous Stem Cell Transplantation for Crohn's Disease autologous CD34-selected peripheral blood stem cells transplant, Alemtuzumab, ATG - Crohn's Disease | Phase 1 / Phase 2 | Recruiting | Paul Szabolcs | 20 | 2012-06-26 | 2025-12-15 |
| Biochemical Correction of Severe EB by Allo HSCT and "Off-the-shelf" MSCs Cyclophosphamide, Fludarabine, Anti-thymocyte globulin - Epidermolysis Bullosa | Phase 1 / Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 32 | 2010-01-01 | 2024-04-03 |
Showing 20 of 31. Sign in to see all of them.
Myelodysplastic Syndromes (9) · Leukemia, Myeloid, Acute (8) · Anemia, Aplastic (6) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (6) · Hodgkin Disease (5) · Leukemia, Lymphocytic, Chronic, B-Cell (5) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (4) · Lymphoma, Non-Hodgkin (4) · Graft vs Host Disease (3) · Hematologic Neoplasms (3) · Leukemia (3) · Lymphoma (3) · Multiple Myeloma (3) · Crohn Disease (2) · Diabetes Mellitus, Type 1 (2)
M.D. Anderson Cancer Center (10) · Masonic Cancer Center, University of Minnesota (2) · Peking University People's Hospital (2) · University of Minnesota (2) · Alice Bertaina (1) · Case Comprehensive Cancer Center (1) · City of Hope Medical Center (1) · Columbia University (1) · Fred Hutchinson Cancer Center (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Memorial Sloan Kettering Cancer Center (1) · Navy General Hospital, Beijing (1) · New York Medical College (1) · Ohio State University Comprehensive Cancer Center (1)
United States (27) · China (1)
Bernhard J. Hering, M.D. (2) · Elizabeth Shpall, MD (2) · Alice Bertaina, MD (1) · Amin M. Alousi, MD (1) · Ann Woolfrey (1) · Chitra Hosing (1) · Issa Khouri (1) · Issa Khouri, MD (1) · Jakub Tolar, MD, PhD (1) · James L. Slack, M.D. (1) · Jessie Alexander, MD (1) · Jonathan Brammer, MD (1) · Kenneth Lucas, M.D. (1) · Margaret L. MacMillan, MD (1) · Martha Q. Lacy, M.D. (1)
PMID 23234514, PMID 25145344, PMID 25778529
P30CA016672 (3), P01CA148600 (2), P01CA100265 (1), P30CA033572 (1), R01CA061508 (1)