78 completed, 31 terminated, 17 unknown, 13 recruiting. 107 Phase 2, 31 Phase 1, 14 Phase 3, 14 Phase 4, 9 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sirolimus+Ruxolitinib+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to CNI Sirolimus, Ruxolitinib, MMF - Acute Leukemia, Myelodysplastic Syndromes | Phase 1 / Phase 2 | Not yet recruiting | Peking University People's Hospital | 40 | 2026-10-01 | 2026-09-09 |
| Phase 1b/2a Trial of Allogeneic HSCT From an HLA-partially Matched Related or Unrelated Donor After TCRab+ T-cell/CD19+ B-cell Depletion for Patients With Monogenic and/or Early-onset Medically Refractory Crohn Disease CliniMACS® TCR α/β Reagent Kit and CliniMACS® CD19 System, Prednisone/Methylprenisolone, Palifermin - Crohn Disease | Phase 1 / Phase 2 | Not yet recruiting | Stanford University | 14 | 2025-07-01 | 2025-05-23 |
| A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia Anti-Thymocyte Globulin, Biospecimen Collection, Bone Marrow Aspirate - Recurrent Severe Aplastic Anemia, Refractory Severe Aplastic Anemia | Phase 1 | Recruiting | City of Hope Medical Center | 6 | 2024-11-15 | 2026-01-05 |
| Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation Methotrexate, Post-Transplant Cyclophosphamide, Fludarabine - Graft Versus Host Disease, Hematologic Malignancy | Phase 2 | Recruiting | Nantes University Hospital | 82 | 2024-07-18 | 2026-01-26 |
| Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin Inhibitors Sirolimus, Abatacept, MMF - Acute Leukemia, Myelodysplastic Syndromes | Phase 1 / Phase 2 | Unknown | Peking University People's Hospital | 6 | 2024-03-01 | 2024-03-21 |
| A Study of TCD601 in de Novo Renal Transplant Recipients TCD601, belatacept, ATG - Renal Transplantation | Phase 2 | Completed | ITB-Med LLC | 76 | 2023-12-28 | 2026-05-05 |
| ATG Plus Low-dose PT-Cy for GVHD Prevention Cyclophosphamid, ATG - Hematologic Malignancy | Phase 3 | Terminated | Peking University People's Hospital | 66 | 2023-11-01 | 2025-06-03 |
| Study Comparing the Efficacy of 2 RIC Regimens (Clofarabine vs Fludarabine) in Adults With AML Eligible to Allo-SCT Fludarabine, Busulfan, ATG - Acute Myeloid Leukemia in Remission | Phase 2 | Recruiting | Nantes University Hospital | 302 | 2023-09-14 | 2026-01-30 |
| MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies Fludarabine, Busulfan, Melphalan - Hematologic Malignancy, Acute Leukemia | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 70 | 2023-05-11 | 2026-04-06 |
| Early Trial of Allogeneic Hematopoietic Stem Cell Transplantation for Patients Who Will Receive a Kidney Transplant From the Same Donor Cyclophosphamide 1200 mg/Kg, Fludarabine, Cyclophosphamide 100 mg/Kg - SIOD, Cystinosis | Phase 1 / Phase 2 | Recruiting | Alice Bertaina | 12 | 2023-01-10 | 2023-07-17 |
| M-PTCy vs BuCy in Haploidentical HSCT for Acute Leukemia mitoxantrone liposome, ATG - Acute Leukemia | Phase 2 / Phase 3 | Unknown | The First Affiliated Hospital of Soochow University | 60 | 2023-01-01 | 2023-02-22 |
| Clinical Study of rATG Individualized Administration in Haploidentical Hematopoietic Stem Cell Transplantation Individual ATG, ATG - Hematopoietic Stem Cell Transplantation, Acute Leukemia | Phase 4 | Unknown | The First Affiliated Hospital of Soochow University | 90 | 2022-12-20 | 2023-02-15 |
| The Optimization of Haploidentical Hematopoietic Stem Cell Transplantation ATG, Post-transplantation cyclophosphamide - Hematological Malignancy | Unknown | Peking University People's Hospital | 300 | 2022-12-01 | 2023-09-11 | |
| Allogeneic Hematopoietic Stem Cell Transplantation for 4/M Neuroblastoma Anti Thymocyte Globulin, Fludarabine, Cyclophosphamide injection - Neuroblastoma | Phase 2 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 64 | 2022-08-01 | 2022-07-01 |
| GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG Cyclophosphamide, ATG - Graft Vs Host Disease, Peripheral Blood Stem Cell Transplantation | Phase 3 | Active not recruiting | DKMS gemeinnützige GmbH | 640 | 2022-03-02 | 2026-08-27 |
| GVHD Prophylaxis by Addition of CD20 Monoclonal Antibody to the Conditioning Regimen in SAA With Treatment of Allo-HSCT CD20 monoclonal antibody, ATG - Aplastic Anemia | Phase 2 | Unknown | The First Affiliated Hospital of Soochow University | 100 | 2021-12-30 | 2022-08-24 |
| A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation TCD601, Tacrolimus (TAC), Corticosteroids (CS) - Kidney Transplantation | Phase 2 | Terminated | ITB-Med LLC | 33 | 2021-06-06 | 2026-03-12 |
| Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation Anti-Thymocyte Globulin, Busulfan, Cyclophosphamide - Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 2 | Withdrawn | Fred Hutchinson Cancer Center | 2021-06-01 | 2021-06-30 | |
| A Dose Escalation Study in de Novo Renal Transplantation TCD601, Tacrolimus (TAC), Corticosteroids (CS) - Kidney Transplantation | Phase 2 | Completed | ITB-Med LLC | 13 | 2021-05-26 | 2025-02-27 |
| Methods of T Cell Depletion Trial (MoTD) Thymoglobulin, Cyclophosphamide, Cyclosporine - Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | University of Birmingham | 400 | 2021-02-22 | 2026-05-05 |
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Myelodysplastic Syndromes (36) · Leukemia, Myeloid, Acute (31) · Lymphoma, Non-Hodgkin (23) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (23) · Leukemia, Lymphocytic, Chronic, B-Cell (22) · Hodgkin Disease (21) · Leukemia (21) · Graft vs Host Disease (19) · Anemia, Aplastic (18) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (17) · Lymphoma (16) · Multiple Myeloma (16) · Myeloproliferative Disorders (15) · Hematologic Neoplasms (14) · Lymphoma, Follicular (11)
M.D. Anderson Cancer Center (30) · Masonic Cancer Center, University of Minnesota (17) · Fred Hutchinson Cancer Center (7) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Nanfang Hospital, Southern Medical University (5) · Stanford University (5) · Peking University People's Hospital (4) · ITB-Med LLC (3) · Nantes University Hospital (3) · National Cancer Institute (NCI) (3) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (3) · The First Affiliated Hospital of Soochow University (3) · University of Illinois at Chicago (3) · Case Comprehensive Cancer Center (2) · Columbia University (2)
United States (115) · China (19) · Austria (4) · Italy (4) · France (3) · Belgium (2) · Brazil (2) · Canada (2) · Germany (2) · United Kingdom (2) · Argentina (1) · Australia (1) · Czechia (1) · Denmark (1) · Finland (1)
Qifa Liu (4) · Damiano Rondelli, MD (3) · Richard E. Champlin, MD (3) · Wen-Kai Weng (3) · Angela Smith, MD (2) · Bernhard J. Hering, M.D. (2) · Chitra M. Hosing, MD (2) · Elizabeth Shpall, MD (2) · Erica Warlick, MD (2) · Fredrik Juhlin (2) · Issa Khouri (2) · Jakub Tolar, MD, PhD (2) · Leona Holmberg (2) · Margaret MacMillan, MD (2) · Paolo Anderlini, MD (2)
PMID 21403127, PMID 22430088, PMID 37341189, PMID 1090310, PMID 15814548, PMID 18997171, PMID 19167681, PMID 19179301, PMID 20383216, PMID 21508125, PMID 21606164, PMID 21816832, PMID 23234514, PMID 23344397, PMID 24077845, PMID 24307695, PMID 24622416, PMID 25145344, PMID 25778529, PMID 26416896, PMID 26899273, PMID 27053235, PMID 27208317, PMID 27855166, PMID 28198767, PMID 29969826, PMID 30843184, PMID 30878319, PMID 30951840, PMID 31212080, PMID 31401973, PMID 32164760, PMID 32343796, PMID 32941647, PMID 33663084, PMID 34724566, PMID 35467818, PMID 37084383, PMID 37335960, PMID 37899481, PMID 37944074, PMID 39348419, PMID 39624016, PMID 40534485, PMID 40534493, PMID 40976248, PMID 41053000, PMID 41438972, PMID 41569644, PMID 41730859
P30CA016672 (4), P30CA015704 (3), P01CA148600 (2), P01HL036444 (2), 2017 (1), 2019 (1), P01CA015396 (1), P01CA049605 (1), P01CA049639 (1), P01CA100265 (1), P30CA006973 (1), P30CA016058 (1), P30CA033572 (1), P30CA036727 (1), R01CA061508 (1)