9 completed, 1 not yet recruiting, 1 recruiting, 1 terminated. 5 Not applicable, 5 Phase 4, 2 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 5 |
| Phase 4 | 5 | Completed 2, Recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow Artificial Tear: new trials by email Literature Review of Artificial Tear trials Research Report on Artificial Tear
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye Disease BRM421 Ophthalmic Solution, 0.03%, Artificial Tear, BRM421 Ophthalmic Solution, 0.06% - Dry Eye Disease (DED), Keratoconjunctivitis Sicca | Phase 2 | Not yet recruiting | BRIM Biotechnology Inc. | 99 | 2025-12-01 | 2025-10-20 |
| Topical Insulin for Ocular Surface Interface in Dry Eye Disease Artificial tear, insulin human - Dry Eye, Insulin Sensitivity | Phase 4 | Completed | Khyber Teaching Hospital | 128 | 2025-04-14 | 2026-08-14 |
| Tear Film Markers in Dry Eye Syndrome Cyclosporine, Artificial tear - Dry Eye | Phase 4 | Withdrawn | Vishal Jhanji | 2023-12-08 | 2023-12-18 | |
| Clinical Trial to Determine the Efficacy and Safety of Insulin Eye Drops in Dry Eye in Patients with Topical Hypotensors Insulin, Artificial tear - Dry Eye, Glaucoma | Phase 4 | Recruiting | Barbara Burgos Blasco | 100 | 2023-02-08 | 2024-10-22 |
| Impact of Vitamin D3 Supplementation in Non-Sjogren Dry Eye Patients With Low Serum Vitamin D Level Vitamin D, Artificial tear - Dry Eye Syndromes, Hypovitaminosis D | Phase 3 | Completed | University of Faisalabad | 108 | 2021-11-01 | 2022-06-21 |
| Acupoint Therapy Device for Dry Eye dry eye acupoint therapy instrument, Artificial tear - Dry Eye | Not applicable | Completed | Shanghai 10th People's Hospital | 120 | 2021-01-01 | 2024-12-06 |
| Influence of Artificial Tears on Keratometry and Biometry Measurements With Different Devices Artificial tear, No artificial tears - Healthy | Not applicable | Completed | University Clinic Frankfurt | 145 | 2020-11-20 | 2024-04-10 |
| Topical Application of Low-concentration (0.01%) Atropine on the Human Eye With Fast and Slow Myopia Progression Rate Atropine (0.01%), Artificial tear - Myopia | Not applicable | Completed | The Hong Kong Polytechnic University | 71 | 2018-02-01 | 2024-10-16 |
| Comparison of the Efficacy of Nepafenac 0.1% and Nepafenac 0.3 % on Pain Associated With Intravitreal Injections Nepafenac 0.1% Oph Susp, Nepafenac 0.3% Oph Susp, Artificial tear - Pain | Not applicable | Completed | University Hospital of Patras | 99 | 2017-09-01 | 2018-04-04 |
| Effects of Dry Eye Treatments on the Ocular Surface Dexamethasone, Artificial tear - Keratoconjunctivitis Sicca, Dry Eye Syndrome | Phase 4 | Completed | Baylor College of Medicine | 20 | 2013-02-01 | 2020-02-05 |
| Ganciclovir 0,15% Ophthalmic Gel in the Treatment of Adenovirus Keratoconjuntivitis Ganciclovir, Artificial tear - Conjunctivitis, Viral, Adenoviridae Infections | Not applicable | Completed | Federal University of São Paulo | 33 | 2009-08-01 | 2011-05-06 |
| Topical IL-1-Ra for Treatment of Posterior Blepharitis 2.5% IL-1Ra, Placebo, 5% IL-1Ra - Posterior Blepharitis | Phase 1 / Phase 2 | Completed | Reza Dana, MD | 75 | 2008-01-01 | 2018-01-19 |
| Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage neomycin sulfate, polymyxin B sulfate and gramicidin, Artificial tear - Hordeolum | Phase 3 | Unknown | Chulalongkorn University | 120 | 2007-09-01 | 2010-11-23 |
| The Prophylactic Use of Topical Cyclosporine A 0.05% to Prevent Graft Versus Host Disease Related Dry Eye Cyclosporine A 0.05%, Arificial Tear - Dry Eye | Phase 4 | Terminated | Massachusetts Eye and Ear Infirmary | 8 | 2007-08-01 | 2017-03-28 |
Dry Eye Syndromes (8) · Keratoconjunctivitis Sicca (2) · Adenoviridae Infections (1) · Conjunctivitis, Viral (1) · Glaucoma (1) · Graft vs Host Disease (1) · Hordeolum (1) · Insulin Resistance (1) · Meibomian Gland Dysfunction (1) · Multiple Acyl Coenzyme A Dehydrogenase Deficiency (1) · Myopia (1) · Pain (1) · Vitamin D Deficiency (1)
BRIM Biotechnology Inc. (1) · Barbara Burgos Blasco (1) · Baylor College of Medicine (1) · Chulalongkorn University (1) · Federal University of São Paulo (1) · Khyber Teaching Hospital (1) · Massachusetts Eye and Ear Infirmary (1) · Reza Dana, MD (1) · Shanghai 10th People's Hospital (1) · The Hong Kong Polytechnic University (1) · University Clinic Frankfurt (1) · University Hospital of Patras (1) · University of Faisalabad (1) · Vishal Jhanji (1)
United States (3) · Pakistan (2) · Brazil (1) · China (1) · Germany (1) · Greece (1) · Hong Kong (1) · Spain (1) · Taiwan (1) · Thailand (1)
Barbara Burgos Blasco, MD, PhD (1) · Bushra Kanwal, MPO (1) · Constantine Georgakopoulos, MD, PhD (1) · Parima Hirunwiwatkul, MD (1) · Reza Dana, M.D. (1) · Reza Dana, MD, MPH, MSc (1) · Shafiq Tanvee, MBBS, FCPS (1) · Simone T Yabiku, MD (1) · Stephen Pflugfelder, MD (1) · Vishal Jhanji, MD (1)