11 completed, 4 unknown, 2 terminated, 2 withdrawn. 20 Phase 2, 5 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 11, Unknown 4, Terminated 2, Withdrawn 2, Recruiting 1 |
| Phase 3 | 5 | Completed 2, Terminated 2, Withdrawn 1 |
| Phase 1 | 1 | Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE) Tissue Plasminogen Activator - Pleural Infection | Phase 2 / Phase 3 | Completed | Chinese University of Hong Kong | 30 | 2024-11-01 | 2026-10-23 |
| Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure Alteplase - Acute Respiratory Failure, Hypercoagulability | Phase 2 | Recruiting | South West Sydney Local Health District | 70 | 2022-05-18 | 2024-04-17 |
| A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke Tirofiban 0.05 MG/ML, 0.9% sodium chloride solution - Acute Ischemic Stroke | Phase 2 | Unknown | GrandPharma (China) Co., Ltd. | 266 | 2021-12-09 | 2023-02-23 |
| Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-II） Alteplase, Tenecteplase - Acute Ischemic Stroke | Phase 2 | Unknown | Beijing Tiantan Hospital | 225 | 2021-05-02 | 2022-03-31 |
| Low Dose Catheter Directed Thrombolysis for Acute Pulmonary Embolism Low dose alteplase, Unfractionated heparin, Infusion catheter - Pulmonary Embolism | Phase 2 | Unknown | University of Aarhus | 60 | 2020-03-10 | 2021-04-28 |
| Dual Thrombolytic Therapy With Mutant Pro-urokinase and Low Dose Alteplase for Ischemic Stroke mutant pro-urokinase, Alteplase - Ischemic Stroke | Phase 2 | Completed | Erasmus Medical Center | 200 | 2019-08-10 | 2023-09-07 |
| Inhaled Tissue Plasminogen Activator for Acute Plastic Bronchitis Treatment-inhaled tPA - Plastic Bronchitis, Protein-Losing Enteropathies | Phase 2 | Completed | University of Michigan | 40 | 2018-03-19 | 2025-08-19 |
| Tirofiban for Patients Treated With Alteplase Tirofiban, Alteplase - Ischemic Stroke | Phase 2 / Phase 3 | Terminated | Capital Medical University | 30 | 2017-12-16 | 2020-09-09 |
| A Trial in Recombinant Human Prourokinase to Treat Acute Pulmonary Embolism Recombinant Human Prourokinase, Alteplase - Acute Pulmonary Embolism | Phase 2 | Completed | Tasly Biopharmaceuticals Co., Ltd. | 108 | 2017-06-06 | 2021-03-18 |
| A Trial of Low-dose Adjunctive alTeplase During prIMary PCI Alteplase, Placebo - Myocardial Infarction | Phase 2 | Completed | NHS Greater Glasgow and Clyde | 440 | 2016-03-01 | 2019-09-06 |
| Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke Tenecteplase, Tissue Plasminogen Activator - Ischemic Stroke | Phase 2 | Completed | Neuroscience Trials Australia | 202 | 2015-03-23 | 2018-03-30 |
| Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage Tissue Plasminogen Activator - Subarachnoid Hemorrhage, Cerebral Vasospasm | Phase 1 / Phase 2 | Withdrawn | Rush University Medical Center | 2015-03-01 | 2015-11-11 | |
| Tenecteplase Versus Alteplase in Ischemic Stroke Management (TALISMAN) Tenecteplase, Alteplase - Ischemic Stroke | Phase 2 / Phase 3 | Withdrawn | Reza Behrouz, DO | 2015-01-01 | 2015-09-23 | |
| Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular AMD Ranibizumab, C3F8 Gas, tPA - Exudative Macular Degeneration, Retinal Hemorrhage | Phase 2 / Phase 3 | Completed | King's College Hospital NHS Trust | 55 | 2014-09-01 | 2020-07-14 |
| Safety of Intravenous Thrombolytics in Stroke on Awakening tPA - Stroke | Phase 2 | Completed | Johns Hopkins University | 20 | 2013-01-01 | 2017-04-17 |
| Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis- (ATTEST) Tenecteplase, alteplase - Stroke | Phase 2 | Completed | NHS Greater Glasgow and Clyde | 104 | 2011-12-01 | 2018-08-03 |
| Wake up Symptomatic Stroke - Benefit of Intravenous Clot Busters or Endovascular Intervention Anti-platelets and statin, alteplase, intra arterial intervention - Stroke | Phase 2 | Unknown | Jacobs Neurological Institute | 90 | 2011-11-01 | 2012-03-30 |
| Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis Endovascular thrombolysis, Heparin - Sinus Thrombosis, Intracranial | Phase 2 / Phase 3 | Terminated | Jan Stam, MD, PhD | 67 | 2011-09-01 | 2017-02-14 |
| Safety of Intravenous Thrombolysis for Wake-up Stroke Alteplase (iv t-PA) - Ischemic Stroke | Phase 2 | Completed | The University of Texas Health Science Center, Houston | 40 | 2010-07-01 | 2014-11-25 |
| Alteplase for Percutaneous Treatment of Loculated Abdominopelvic Abscesses Alteplase, saline - Abdominal Abscess, Pelvic Abscess | Phase 2 | Completed | Kaiser Permanente | 20 | 2006-02-01 | 2015-02-26 |
Ischemic Stroke (7) · Stroke (4) · Abdominal Abscess (1) · Cerebral Infarction (1) · Heart Defects, Congenital (1) · Hydrocephalus (1) · Intracranial Aneurysm (1) · Intracranial Hemorrhages (1) · Intracranial Thrombosis (1) · Macular Degeneration (1) · Myocardial Infarction (1) · Protein-Losing Enteropathies (1) · Pulmonary Embolism (1) · Retinal Hemorrhage (1) · Sinus Thrombosis, Intracranial (1)
NHS Greater Glasgow and Clyde (2) · Beijing Tiantan Hospital (1) · Capital Medical University (1) · Chinese University of Hong Kong (1) · Erasmus Medical Center (1) · GrandPharma (China) Co., Ltd. (1) · Jacobs Neurological Institute (1) · Jan Stam, MD, PhD (1) · Johns Hopkins University (1) · Kaiser Permanente (1) · King's College Hospital NHS Trust (1) · Neuroscience Trials Australia (1) · Reza Behrouz, DO (1) · Rush University Medical Center (1) · South West Sydney Local Health District (1)
United States (7) · China (5) · United Kingdom (3) · Australia (2) · Netherlands (2) · Canada (1) · Denmark (1) · France (1) · Hong Kong (1) · New Zealand (1) · Portugal (1) · Switzerland (1)
Anders Aneman (1) · Andrew D Barreto, MD (1) · Asger Andersen, MD, PhD (1) · Charles BL Majoie, MD, PhD (1) · Colin Berry, Prof (1) · David SC Hui, MD (1) · E Houdart, MD, PhD (1) · Elad I Levy, MD (1) · Hyo-Chun Yoon, MD, PhD (1) · Isabelle Crassard, MD, PhD (1) · Jan Stam, MD, PhD (1) · Jim A Reekers, MD, PhD (1) · Jose M Ferro, MD, PhD (1) · Kathleen A Stringer, PharmD (1) · Keith Muir (1)
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