50 completed, 12 unknown, 9 terminated, 8 recruiting. 35 Phase 3, 20 Phase 2, 13 Phase 4, 9 Not applicable, 2 Phase 1.
Follow Alteplase: new trials by email Literature Review of Alteplase trials Research Report on Alteplase
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| INtra-arterial AltEplase folloWing successfuL reperfusIoN After mEchanical Thrombectomy Alteplase, Endovascular thrombectomy - Stroke, Acute Ischemic, Large Vessel Occlusion | Phase 3 | Recruiting | 115 People's Hospital | 416 | 2026-08-01 | 2026-09-25 |
| Flush, Lyse, Operate Intrapleural Saline with possible escalation to intraplerual alteplase and dornase. - Complicated Parapneumonic Effusion, Empyema, Pleural | Phase 4 | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 30 | 2026-04-01 | 2026-05-18 |
| Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke Tenecteplase, Alteplase - Stroke, Ischemic, Stroke, Acute | Phase 3 | Recruiting | Xuanwu Hospital, Beijing | 850 | 2025-12-25 | 2026-04-09 |
| Reperfusion Treatment in Acute Pulmonary Embolism Catheter directed intervention, any device, Alteplase - Pulmonary Embolism | Recruiting | Sahlgrenska University Hospital | 220 | 2025-04-01 | 2026-01-21 | |
| Thrombolysis in Factor Xa-inhibitors Trial thrombolysis therapy - Stroke, Stroke (in Patients With Atrial Fibrillation) | Phase 3 | Recruiting | Guri Hagberg | 300 | 2025-03-14 | 2026-09-23 |
| Endovascular Treatment or Standard Medical Care for Cerebral Venous Sinus Thrombosis(ESCORT) Heparin, Endovascular treatment - Cerebral Venous Sinus Thrombosis | Not applicable | Active not recruiting | Beijing Tiantan Hospital | 224 | 2024-12-24 | 2026-08-21 |
| To Compare the Efficacy & Safety of Ultra-Slow (24 hr) Low Dose (25 mg) Infusion of Alteplase Over Slow (24hr) Infusion of Streptokinase in Mechanical Prosthetic Valve Thrombosis Alteplase, streptokinase - Thrombolysed | Not applicable | Completed | U. N. Mehta Institute of Cardiology and Research Center | 100 | 2024-11-01 | 2026-01-26 |
| Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE) Tissue Plasminogen Activator - Pleural Infection | Phase 2 / Phase 3 | Completed | Chinese University of Hong Kong | 30 | 2024-11-01 | 2026-10-23 |
| A Real-world Study of Tenecteplase Versus Alteplase for Thrombolysis in Patients Within 4.5 H of Onset of Ischemic Stroke Tenecteplase, Alteplase - Stroke Acute, Tenecteplase | Unknown | Tianjin Huanhu Hospital | 6000 | 2024-10-26 | 2024-10-29 | |
| Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study Urokinase, Alteplase - Acute Ischemic Stroke | Recruiting | The First Affiliated Hospital of Zhengzhou University | 1800 | 2023-12-30 | 2024-01-08 | |
| Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion Alteplase, Placebo Administration - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Early Phase 1 | Recruiting | M.D. Anderson Cancer Center | 30 | 2023-08-17 | 2026-08-17 |
| Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical Thrombectomy Alteplase - Stroke, Acute Ischemic | Phase 3 | Completed | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 324 | 2023-08-01 | 2026-08-12 |
| Aspirin Combined With Clopidogrel Versus Intravenous Alteplase for Acute Minor Stroke Aspirin, Clopidogrel, Alteplase - Ischemic Stroke | Phase 4 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 472 | 2023-07-01 | 2023-06-18 |
| Dual IntraVenous Thrombolysis Approach (DIVA) in Patients With Medium-vessel-occlusion Strokes: a Retrospective Study alteplase, Alteplase + possible complementary IVT with tenecteplase - Acute Ischemic Stroke Due to Medium-vessel-occlusion | Completed | Centre Hospitalier Sud Francilien | 294 | 2023-05-17 | 2023-11-07 | |
| Tenecteplase Thrombolytic Therapy for Acute Ischemic Stroke in China Tenecteplase, Alteplase - Ischemic Stroke | Unknown | Huashan Hospital | 1200 | 2023-04-02 | 2023-10-12 | |
| Mechanical Thrombectomy With the FlowTriever Device in Acute Pulmonary Embolism - a Retrospective Analysis Mechanical thrombectomy, Intravenous thrombolysis - Pulmonary Embolism | Completed | Kristina Svennerholm | 132 | 2023-04-01 | 2025-05-20 | |
| Alteplase in Elderly Acute Ischemic Stroke (AIS) Patients During Hospitalization rt-PA - Stroke | Completed | Boehringer Ingelheim | 113035 | 2022-11-30 | 2024-12-20 | |
| Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ） Alteplase, Tenecteplase - Acute Ischemic Stroke | Phase 3 | Unknown | Beijing Tiantan Hospital | 1630 | 2022-10-26 | 2023-02-27 |
| the Predictors of Hemorrhagic Transformation Subtypes in Acute Embolic Stroke Patients Alteplase - Ischemic Stroke, Alteplase Adverse Reaction | Phase 4 | Recruiting | Kafrelsheikh University | 716 | 2022-07-01 | 2024-10-29 |
| Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure Alteplase - Acute Respiratory Failure, Hypercoagulability | Phase 2 | Recruiting | South West Sydney Local Health District | 70 | 2022-05-18 | 2024-04-17 |
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Ischemic Stroke (29) · Stroke (24) · Pulmonary Embolism (8) · Thrombosis (6) · Myocardial Infarction (4) · ST Elevation Myocardial Infarction (4) · Cerebral Infarction (3) · Intracranial Hemorrhages (3) · Intracranial Thrombosis (3) · Postthrombotic Syndrome (3) · Venous Thrombosis (3) · Bites and Stings (2) · Brain Ischemia (2) · Empyema (2) · Ventricular Dysfunction, Right (2)
Boehringer Ingelheim (7) · Beijing Tiantan Hospital (3) · General Hospital of Shenyang Military Region (3) · Johns Hopkins University (3) · Kafrelsheikh University (3) · NHS Greater Glasgow and Clyde (3) · Boston Scientific Corporation (2) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (2) · Supergene, LLC (2) · Tanabe Pharma Corporation (2) · Tasly Biopharmaceuticals Co., Ltd. (2) · 115 People's Hospital (1) · Angde Biotech Pharmaceutical Co., Ltd. (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1)
China (25) · United States (23) · Canada (8) · United Kingdom (7) · France (5) · Spain (5) · Sweden (5) · Denmark (4) · Egypt (4) · Germany (4) · Australia (3) · Belgium (3) · Israel (3) · Netherlands (3) · Norway (3)
Daniel F. Hanley, MD (2) · Sergey S Markin, MD, PhD (2) · Shuya Li (2) · Yamei Tang (2) · Aaron S Weinberg, MD (1) · Ahmed Hamdy, Ass.Prof (1) · Albert Kadri, MD (1) · Alberto Conti, MD (1) · Alexander I Kirienko, MD, PhD (1) · Anders Aneman (1) · Andrew D Barreto, MD (1) · Asger Andersen, MD, PhD (1) · Azhar Supariwala, MD (1) · Barry S Weinstock, MD (1)
PMID 12221155, PMID 16731270, PMID 34515113, PMID 22435369, PMID 25726502, PMID 26387127, PMID 28780236, PMID 29694815, PMID 36446950, PMID 37830342, PMID 39500603, PMID 10591382, PMID 11546885, PMID 12917889, PMID 16574919, PMID 16763187, PMID 18705914, PMID 18815396, PMID 19233036, PMID 20047905, PMID 20075341, PMID 20185783, PMID 20651267, PMID 21030700, PMID 21737309, PMID 22015331, PMID 22340437, PMID 23264523, PMID 23418571, PMID 23493340, PMID 23537968, PMID 24298176, PMID 25212800, PMID 25628404, PMID 25638754, PMID 26243227, PMID 26315743, PMID 26514192, PMID 26763281, PMID 27273860, PMID 27756804, PMID 27913777, PMID 27965285, PMID 28081952, PMID 28174327, PMID 28425349, PMID 28842449, PMID 28844990, PMID 28887375, PMID 28928186
2018 (2), 2019 (1), 2023 (1), U01HL088476 (1), U01NS062851 (1), U01NS080824 (1)