11 completed, 3 unknown, 1 withdrawn. 15 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 11, Unknown 3, Withdrawn 1 |
| Phase 1 | 2 | Completed 2 |
Follow adefovir dipivoxil: new trials by email Literature Review of adefovir dipivoxil trials Research Report on adefovir dipivoxil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Safety and Dose-range Study of Metacavir Enteric-coated Capsules in Patients With Chronic Hepatitis B Metacavir Enteric-coated Capsules 80mg, Metacavir Enteric-coated Capsules 160mg, Metacavir Enteric-coated Capsules 320mg - Chronic Hepatitis B | Phase 2 | Unknown | Guangzhou Yipinhong Pharmaceutical CO.,LTD | 180 | 2012-12-01 | 2016-11-22 |
| A Phase II Study to Determine the Safety and Efficacy of Interferon-gamma in Patients With Chronic Hepatitis B IFN-γ 1b (Actimmune), Adefovir dipivoxil, IFN-γ 1b and Adefovir dipivoxil combination - Hepatitis B | Phase 2 | Unknown | Huntington Medical Research Institutes | 30 | 2008-09-01 | 2010-10-21 |
| Adefovir Plus Vaccination in Transplant Patients Without Hepatitis B That Receive a Core Antibody Positive Liver Adefovir dipivoxil and hepatitis B vaccination - Hepatitis B, Liver Transplantation | Phase 1 / Phase 2 | Completed | Columbia University | 16 | 2006-03-01 | 2021-08-10 |
| PK Study of Tacrolimus and Cyclosporine When Co-Administered With Adefovir Dipivoxil in Post-Liver Transplant Patients Adefovir Dipivoxil - Hepatitis B | Phase 2 | Completed | Gilead Sciences | 16 | 2004-02-01 | 2008-04-10 |
| Open Label Study of Pharmacokinetics and Safety of Dose of Adefovir Dipivoxil in Children and Adolescents With HBV Adefovir dipivoxil, Adefovir Dipivoxil - Hepatitis B | Phase 1 / Phase 2 | Completed | Gilead Sciences | 47 | 2003-02-01 | 2008-03-27 |
| The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined With Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs Ritonavir, Nelfinavir mesylate, Efavirenz - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 300 | 2021-11-01 | |
| Treatment Success and Failure in HIV-Infected Subjects Receiving Indinavir in Combination With Nucleoside Analogs: A Rollover Study for ACTG 320 Indinavir sulfate, Abacavir sulfate, Nelfinavir mesylate - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 440 | 2021-10-28 | |
| Safety and Effectiveness of Adding Adefovir Dipivoxil and Nelfinavir to the Anti-HIV Therapy of HIV-Infected Children Nelfinavir mesylate, Levocarnitine, Adefovir dipivoxil - HIV Infections | Phase 2 | Unknown | Gilead Sciences | 36 | 2005-06-24 | |
| Safety and Effectiveness of Giving Adefovir Dipivoxil Plus Abacavir Plus Efavirenz Plus Amprenavir to HIV-Infected Patients Who Have Failed to Respond to Previous Protease Inhibitor Treatment Abacavir sulfate, Amprenavir, Efavirenz - HIV Infections | Phase 2 | Completed | Gilead Sciences | 25 | 2005-06-24 | |
| Safety and Effectiveness of Giving an Anti-HIV Drug Combination of Adefovir Dipivoxil Plus Didanosine Plus Efavirenz Plus Lamivudine Once Daily to HIV-Infected Patients Efavirenz, Adefovir dipivoxil, Lamivudine - HIV Infections | Phase 2 | Completed | Gilead Sciences | 25 | 2005-06-24 | |
| The Safety and Effectiveness of Adefovir Dipivoxil Plus Indinavir Combined With Zidovudine or Lamivudine or Stavudine in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs Indinavir sulfate, Levocarnitine, Adefovir dipivoxil - HIV Infections | Phase 2 | Completed | Gilead Sciences | 100 | 2005-06-24 | |
| Treatment of Hepatitis in Patients Who Are Triple-Infected With HIV, Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) Adefovir dipivoxil, Peginterferon-alfa-2A, Ribavirin - HIV Infections, Hepatitis B | Phase 2 | Withdrawn | National Institute of Allergy and Infectious Diseases (NIAID) | 2021-11-01 | ||
| A Study on Amprenavir in Combination With Other Anti-HIV Drugs in HIV-Positive Patients Indinavir sulfate, Abacavir sulfate, Amprenavir - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 475 | 2021-10-29 | |
| A Comparison of Adefovir and Tenofovir for the Treatment of Lamivudine-Resistant Hepatitis B Virus in People With HIV Adefovir dipivoxil, Tenofovir disoproxil fumarate - HIV Infections, Hepatitis B | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 90 | 2021-11-01 | |
| A Phase II, Stratified, Randomized, Double-Blind, Multi-Center Study of the Safety and Efficacy of Adefovir Dipivoxil (ADF) at Two Dose Levels in Triple Combination Therapies With Protease Inhibitors (PI) and Nucleoside Reverse Transcriptase Inhibitors (RTI) for the Treatment of HIV-Infected Patient Nelfinavir mesylate, Levocarnitine, Adefovir dipivoxil - HIV Infections | Phase 2 | Completed | Gilead Sciences | 120 | 2005-06-24 |
HIV Infections (10) · Hepatitis B (6) · Acquired Immunodeficiency Syndrome (2) · Disease Progression (1) · Hepatitis B, Chronic (1) · Hepatitis C (1)
Gilead Sciences (7) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Columbia University (1) · Guangzhou Yipinhong Pharmaceutical CO.,LTD (1) · Huntington Medical Research Institutes (1)
United States (12) · Puerto Rico (5) · Belgium (1) · China (1) · Germany (1) · Poland (1) · United Kingdom (1)
Scott Hammer (3) · Bruce Polsky, MD (1) · David Katzenstein (1) · Dickens Theodore, M.D., Ph.D. (1) · John Mellors (1) · Jun Li (1) · Kenneth E Sherman, M.D., Ph.D (1) · Maorong Wang (1) · Marion Peters, MD (1) · Mary Albrecht (1) · Myron J Tong, Phd, MD (1) · Robert S Brown, Jr, MD, MPH (1) · Yanlin Yu (1) · Yongfeng Yang (1) · Yonggang Li (1)
PMID 15940636, PMID 15994231, PMID 16912304, PMID 17030856, PMID 17058225, PMID 17726714, PMID 2106474, PMID 21239359, PMID 21337357, PMID 2452123, PMID 31099252, PMID 3129521