26 completed, 6 recruiting, 3 terminated, 3 unknown. 43 Phase 2, 9 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 43 | Completed 26, Recruiting 6, Terminated 3, Unknown 3, Withdrawn 3, Not yet recruiting 2 |
| Phase 1 | 9 | Completed 6, Not yet recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 3 | Completed 3 |
Follow Urinary Calculi: new trials by email Literature Review of Urinary Calculi trials Research Report on Urinary Calculi
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of TRA16 Administered Orally in Patients With Enteric Hyperoxaluria (EH). TRA16, Placebo - Enteric Hyperoxaluria | Phase 2 | Not yet recruiting | Wuhan Kangfude Urolithiasis Research Institute Co., Ltd. | 30 | 2027-03-01 | 2026-10-13 |
| Study of YOLT-203 in Children and Adults With Primary Hyperoxaluria Type 1 (PH1) YOLT-203, Placebo - Primary Hyperoxaluria Type 1, PH1 | Phase 2 | Recruiting | YolTech Therapeutics Co., Ltd | 36 | 2026-09-16 | 2026-10-09 |
| Intravesical Aminophylline to Facilitate Ureteroscopic Access in Children With Distal Ureteral Stones. Aminophylline, Normal Saline Placebo - Pediatric Urolithiasis, Distal Ureteral Stone | Phase 2 | Recruiting | Beni-Suef University | 60 | 2026-05-09 | 2026-06-01 |
| Melatonin and Solifenacin for Double-J Ureteral Stent Symptoms Solifenacin, Melatonin - Ureteral Stent-Related Symptoms, Ureteral Calculi | Phase 2 | Recruiting | Beni-Suef University | 189 | 2026-05-07 | 2026-06-02 |
| L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones L-Citrulline, Tamsulosin - Distal Ureteral Stone, Urolithiasis | Phase 2 | Recruiting | Beni-Suef University | 120 | 2026-05-06 | 2026-06-01 |
| Intravesical Aminophylline for Urgent Ureteral Stenting in Acute Calculous Anuria Intravesical Aminophylline, Placebo Saline - Acute Calculous Anuria, Ureteral Calculi | Phase 2 | Recruiting | Beni-Suef University | 72 | 2026-04-08 | 2026-06-02 |
| Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones Potassium Citrate, Sodium Bicarbonate - Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis | Phase 1 / Phase 2 | Not yet recruiting | University of California, Los Angeles | 30 | 2026-02-01 | 2026-02-12 |
| A Phase 2a Study of LLX-424 in Patients With a History of Kidney Stones LLX-424 - Kidney Stones | Phase 2 | Completed | Lilac Therapeutics, Inc. | 51 | 2025-03-23 | 2025-10-29 |
| Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention Indapamide 2.5 MG, Hydrochlorothiazide 50Mg, Chlorthalidone 25mg - Kidney Stone | Phase 2 | Recruiting | Insel Gruppe AG, University Hospital Bern | 99 | 2024-10-01 | 2026-05-06 |
| Erector Spinae Plane Block for Uncomplicated Renal Colic Erector Spinae Plane Block (ESPB), Ropivacaine - Renal Colic, Kidney Stone | Phase 2 | Completed | University of Michigan | 5 | 2023-02-08 | 2025-10-30 |
| Research Project: Pilot Study on Oral Urea Use in Patients at High Risk of Kidney Stone Recurrence Ure-Na - Kidney Stone | Phase 2 | Withdrawn | Centre hospitalier de l'Université de Montréal (CHUM) | 2023-01-15 | 2022-11-28 | |
| Silodosin in Management of Lower Ureteral Stones Silodosin - Stone, Kidney | Phase 1 / Phase 2 | Completed | Syrian Private University | 100 | 2022-10-20 | 2024-04-24 |
| A Study to Evaluate Lumasiran in Adults With Recurrent Calcium Oxalate Kidney Stone Disease and Elevated Urinary Oxalate Levels Lumasiran, Placebo - Recurrent Calcium Oxalate Kidney Stone Disease, Elevated Urinary Oxalate Levels | Phase 2 | Terminated | Alnylam Pharmaceuticals | 2 | 2022-01-27 | 2024-05-22 |
| Impact of the SGLT2 Inhibitor Empagliflozin on Urinary Supersaturations in Kidney Stone Formers Empagliflozin 25 MG, Placebo - Kidney Stone | Phase 2 | Completed | Insel Gruppe AG, University Hospital Bern | 50 | 2021-08-25 | 2023-05-12 |
| Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects NOV-001, NB1000S, NB2000P - Healthy Volunteers, Enteric Hyperoxaluria | Phase 1 / Phase 2 | Terminated | Novome Biotechnologies Inc | 153 | 2021-06-02 | 2023-05-17 |
| A Study to Assess the Effect of Cannabidiol Oil on Pain After Ureteroscopy for Kidney Stones Cannabidiol, Placebo - Urinary Stone | Phase 2 / Phase 3 | Completed | Mayo Clinic | 90 | 2021-02-15 | 2023-01-18 |
| Perioperative Pregabalin in Ureteroscopy Pregabalin 300mg, Placebo oral tablet - Kidney Stone, Pain, Postoperative | Phase 2 / Phase 3 | Completed | University of Missouri-Columbia | 118 | 2020-06-01 | 2025-11-12 |
| Pramipexole and Morphine for Renal Colic Pramipexole, Morphine, Placebo oral tablet - Renal Colic | Phase 1 / Phase 2 | Completed | East Carolina University | 19 | 2019-10-28 | 2023-03-08 |
| Treatment of Renal Stones With Frankincense (Luban) AKBA-Incense (3-acetyl-11-keto-ß-boswellic acid), Potassium Sodium Hydrogen Citrate - Renal Stones | Phase 1 / Phase 2 | Unknown | Sultan Qaboos University | 100 | 2019-09-01 | 2019-04-29 |
| Efficacy and Safety of Renalof® in the Removal of Calculi Smaller Than 10 mm Located in the Reno-Ureteral Tract Renalof, Placebo - Renal Injury, Kidney Injury | Phase 2 | Completed | Catalysis SL | 155 | 2019-08-01 | 2021-01-06 |
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Kidney Calculi (37) · Nephrolithiasis (11) · Urolithiasis (9) · Hyperoxaluria (6) · Ureteral Calculi (6) · Kidney Diseases (5) · Calculi (3) · Renal Colic (3) · Urologic Diseases (3) · Crohn Disease (2) · Cystinuria (2) · Hyperoxaluria, Primary (2) · Nephrolithiasis, Calcium Oxalate (2) · Pain, Postoperative (2)
Female Urogenital Diseases (43) · Female Urogenital Diseases and Pregnancy Complications (43) · Male Urogenital Diseases (43) · Pathological Conditions, Anatomical (43) · Pathological Conditions, Signs and Symptoms (43) · Urogenital Diseases (43) · Calculi (40) · Urologic Diseases (40) · Urolithiasis (34) · Kidney Diseases (33) · Nephrolithiasis (26) · Signs and Symptoms (8) · Ureteral Diseases (7) · Neurologic Manifestations (6)
oxalate decarboxylase (4) · reloxaliase (4) · silodosin (3) · Isoproterenol (2) · Ketorolac Tromethamine (2) · Potassium Citrate (2) · Allopurinol (1) · Aminophylline (1) · Cannabidiol (1) · Chlorthalidone (1) · Citrates (1) · Citric Acid (1) · Citrulline (1) · Febuxostat (1) · Frankincense (1)
Allena Pharmaceuticals (4) · Beni-Suef University (4) · Mayo Clinic (3) · Fredericia Hosptial (2) · Insel Gruppe AG, University Hospital Bern (2) · University of Texas Southwestern Medical Center (2) · Alnylam Pharmaceuticals (1) · Amai Charitable Trust (1) · Catalysis SL (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · East Carolina University (1) · Isfahan University of Medical Sciences (1) · Kissei Pharmaceutical Co., Ltd. (1) · Lilac Therapeutics, Inc. (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1)
United States (24) · Canada (4) · Egypt (4) · Switzerland (3) · Denmark (2) · United Kingdom (2) · Belgium (1) · Germany (1) · Iceland (1) · India (1) · Iran (1) · Italy (1) · Japan (1) · Nicaragua (1) · Oman (1)
Hany F Badawy, MD (4) · Annamaria Kausz, MD MS (2) · Chris Fung (1) · Daniel Fuster, MD (1) · Daniel G Fuster, M.D. (1) · David Clark, MD (1) · Davis J Viprakasit, MD (1) · Helene U Jung (1) · Jamshid Roozbeh, MD (1) · John C Lieske, MD (1) · John D Denstedt, MD, FRCSC (1) · Jon I Scheinman, M.D. (1) · Karen Stern, MD (1) · Katie Murray, DO (1) · Kori Brewer, PhD (1)
PMID 20736987, PMID 21161651, PMID 21419606, PMID 23929928, PMID 30783888, PMID 34569278, PMID 35288397, PMID 39411383, PMID 39747681
P50DK083007 (2), 2005 (1), 2017 (1), P20DK100863 (1), R21AT002534 (1), R21DK072454 (1), R21DK097476 (1), UL1RR024150 (1)