12 completed, 1 withdrawn. 7 Phase 2, 4 Phase 1, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 7 |
| Phase 1 | 4 | Completed 4 |
| Not applicable | 2 | Completed 2 |
Follow Untreated Childhood Acute Lymphoblastic Leukemia: new trials by email Literature Review of Untreated Childhood Acute Lymphoblastic Leukemia trials Research Report on Untreated Childhood Acute Lymphoblastic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic Leukemia laboratory biomarker analysis - B-cell Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia | Completed | Children's Oncology Group | 40 | 2012-06-01 | 2016-05-18 | |
| Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia treosulfan, fludarabine phosphate, total-body irradiation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 96 | 2009-02-01 | 2021-06-22 |
| Nilotinib and Imatinib Mesylate After Donor Stem Cell Transplant in Treating Patients With ALL or CML nilotinib, imatinib mesylate, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 2008-08-14 | 2017-08-10 |
| Studying Body Mass Index in Younger Patients Who Are Receiving Treatment for High-Risk Acute Lymphoblastic Leukemia Daunorubicin Hydrochloride, Pharmacological Study, Prednisolone - Acute Lymphoblastic Leukemia, Untreated Childhood Acute Lymphoblastic Leukemia | Withdrawn | Children's Oncology Group | 2008-03-24 | 2018-08-07 | ||
| Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia Cognitive Assessment, Diffusion Tensor Imaging, Laboratory Biomarker Analysis - Childhood B Acute Lymphoblastic Leukemia, Childhood T Acute Lymphoblastic Leukemia | Completed | Children's Oncology Group | 233 | 2007-01-01 | 2017-07-21 | |
| Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma doxorubicin hydrochloride, cyclophosphamide, methotrexate - Childhood Burkitt Lymphoma, Childhood Diffuse Large Cell Lymphoma | Phase 2 | Completed | Children's Oncology Group | 97 | 2004-06-01 | 2014-09-19 |
| Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer fludarabine phosphate, total-body irradiation, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 150 | 2004-04-01 | 2020-01-29 |
| Risk-Group Classification of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia laboratory biomarker analysis - Untreated Adult Acute Lymphoblastic Leukemia, Untreated Childhood Acute Lymphoblastic Leukemia | Completed | Children's Oncology Group | 11196 | 2003-12-01 | 2023-08-03 | |
| Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 37 | 2003-09-01 | 2020-01-18 |
| Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia allopurinol, cyclophosphamide, daunorubicin hydrochloride - Acute Undifferentiated Leukemia, B-cell Adult Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 302 | 2003-06-01 | 2022-05-03 |
| Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer Fludarabine Phosphate, Total-Body Irradiation, Peripheral Blood Stem Cell Transplantation - Adult Acute Myeloid Leukemia in Remission, Childhood Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 106 | 2001-08-01 | 2019-12-20 |
| Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia prednisone, vincristine sulfate, daunorubicin hydrochloride - T-cell Childhood Acute Lymphoblastic Leukemia, Untreated Childhood Acute Lymphoblastic Leukemia | Not applicable | Completed | National Cancer Institute (NCI) | 100 | 2001-04-01 | 2013-01-16 |
| Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies fludarabine phosphate, total-body irradiation, peripheral blood stem cell transplantation - Acute Myeloid Leukemia/Transient Myeloproliferative Disorder, Acute Undifferentiated Leukemia | Not applicable | Completed | Fred Hutchinson Cancer Center | 160 | 2000-12-01 | 2020-01-21 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma (9) · Leukemia, Myeloid, Acute (5) · Burkitt Lymphoma (4) · Congenital Abnormalities (4) · Dendritic Cell Sarcoma, Interdigitating (4) · Hodgkin Disease (4) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Leukemia, Myeloid, Accelerated Phase (4) · Leukemia, Myelomonocytic, Chronic (4) · Lymphoma, Large B-Cell, Diffuse (4) · Lymphoma, Non-Hodgkin (4) · Blast Crisis (3) · Immunoblastic Lymphadenopathy (3) · Leukemia, Hairy Cell (3) · Leukemia, Myeloid, Chronic-Phase (3)
Hemic and Lymphatic Diseases (10) · Immune System Diseases (10) · Immunoproliferative Disorders (10) · Lymphatic Diseases (10) · Lymphoproliferative Disorders (10) · Neoplasms (10) · Neoplasms by Histologic Type (10) · Hematologic Diseases (9) · Leukemia (9) · Leukemia, Lymphoid (9) · Bone Marrow Diseases (6) · Chronic Disease (6) · Disease Attributes (6) · Leukemia, Myeloid (6) · Pathologic Processes (6)
Peripheral Blood Stem Cell Transplantation (5) · Whole-Body Irradiation (5) · fludarabine phosphate (5) · Methotrexate (4) · Mycophenolic Acid (4) · Vincristine (4) · Cyclophosphamide (3) · Cyclosporine (3) · Cytarabine (3) · Daunorubicin (3) · Leucovorin (3) · Prednisone (3) · merphos (3) · Asparaginase (2) · Dexamethasone (2)
Fred Hutchinson Cancer Center (6) · Children's Oncology Group (5) · National Cancer Institute (NCI) (2)
United States (13) · Italy (4) · Germany (3) · Australia (2) · Canada (2) · New Zealand (2) · Puerto Rico (1) · Switzerland (1)
Brenda Sandmaier (2) · David Maloney (2) · Boglarka Gyurkocza (1) · Ian Pollack (1) · Kimberly Dunsmore (1) · Mignon Loh, MD (1) · Mitchell Cairo, MD CCRP (1) · Naomi Winick (1) · Paul Carpenter (1) · Wendy Stock (1) · William Carroll, MD (1)
PMID 32499241, PMID 30117142, PMID 30742559
P30CA015704 (5), U10CA098543 (4), P01CA018029 (3), P01CA078902 (1), P01HL036444 (1), U10CA031946 (1), U10CA095861 (1)