4 completed, 1 active not recruiting, 1 terminated. 6 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 6 | Completed 4, Active not recruiting 1, Terminated 1 |
Follow Tuberous Sclerosis: new trials by email Literature Review of Tuberous Sclerosis trials Research Report on Tuberous Sclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate Behavioral and Other Co-Occurring Outcomes With Epidiolex as Add-On Therapy in Participants Aged 1 to 65 Years of Age With Tuberous Sclerosis Complex Cannabidiol Oral Solution [Epidiolex] - Tuberous Sclerosis Complex Associated Neuropsychiatric Disease | Phase 4 | Completed | Jazz Pharmaceuticals | 79 | 2023-06-29 | 2026-04-27 |
| A Phase IV Study of Safety and Efficacy of Everolimus in Taiwanese Patients With Tuberous Sclerosis Complex Who Have Renal Angiomyolipoma (TSC-AML) Everolimus - Renal Angiomyolipoma | Phase 4 | Completed | Novartis Pharmaceuticals | 4 | 2023-05-01 | 2026-10-29 |
| Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution Cannabidiol - Lennox Gastaut Syndrome, Dravet Syndrome | Phase 4 | Active not recruiting | Jazz Pharmaceuticals | 154 | 2021-07-07 | 2026-08-26 |
| Safety and Efficacy of Everolimus (Afinitor®) in Chinese Adult Patients With Angiomyolipoma Associated With Tuberous Sclerosis Complex. Everolimus - Renal Angiomyolipoma | Phase 4 | Completed | Novartis Pharmaceuticals | 40 | 2018-11-09 | 2021-09-09 |
| Sabril for Complex Partial Seizures in Adult Tolerability Study (TS) Patients vigabatrin - Complex Partial Seizures | Phase 4 | Terminated | University of Pennsylvania | 1 | 2010-08-01 | 2017-07-12 |
| Doxycycline In Lymphangioleiomyomatosis (LAM) Doxycycline, Placebo - Lymphangioleiomyomatosis, Tuberous Sclerosis | Phase 4 | Completed | University of Nottingham | 24 | 2009-07-01 | 2015-12-02 |
Angiomyolipoma (2) · Lymphangioleiomyomatosis (2) · Seizures (2) · Behavior (1) · Epilepsies, Myoclonic (1) · Lennox Gastaut Syndrome (1) · Liver Cirrhosis (1)
Congenital Abnormalities (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Genetic Diseases, Inborn (6) · Hamartoma (6) · Heredodegenerative Disorders, Nervous System (6) · Malformations of Cortical Development (6) · Malformations of Cortical Development, Group I (6) · Neoplasms (6) · Neoplasms, Multiple Primary (6) · Neoplastic Syndromes, Hereditary (6) · Nervous System Diseases (6) · Nervous System Malformations (6) · Neurocutaneous Syndromes (6) · Neurodegenerative Diseases (6) · Neoplasms by Histologic Type (3)
Cannabidiol (2) · Everolimus (2) · Doxycycline (1) · Vigabatrin (1)
Jazz Pharmaceuticals (2) · Novartis Pharmaceuticals (2) · University of Nottingham (1) · University of Pennsylvania (1)
United States (3) · United Kingdom (2) · Canada (1) · China (1) · Poland (1) · Taiwan (1)
John Pollard, MD (1) · Simon R Johnson, DM FRCP (1)
2023 (1)