6 completed, 3 terminated. 4 Phase 2, 3 Not applicable, 1 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 4 |
| Not applicable | 3 | Completed 2, Terminated 1 |
| Early Phase 1 | 1 | Terminated 1 |
| Phase 1 | 1 | Terminated 1 |
Follow Stage III Oropharyngeal Squamous Cell Carcinoma: new trials by email Literature Review of Stage III Oropharyngeal Squamous Cell Carcinoma trials Research Report on Stage III Oropharyngeal Squamous Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery Paclitaxel, Carboplatin, Nivolumab - Name Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Stage II Oropharyngeal Squamous Cell Carcinoma | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 34 | 2017-11-13 | 2025-04-24 |
| Prepare to Care, A Supported Self-Management Intervention for Head and Neck Cancer CaregiversHead and Neck Cancer Communication Intervention, Watch video, Module completion of the Prepare to Care kit - Caregiver, Malignant Head and Neck Neoplasm | Not applicable | Completed | Wake Forest University Health Sciences | 35 | 2017-05-15 | 2023-01-09 |
| Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer Durvalumab, Laboratory Biomarker Analysis, Therapeutic Conventional Surgery - Human Papillomavirus Infection, Stage I Oral Cavity Squamous Cell Carcinoma | Early Phase 1 | Terminated | Wake Forest University Health Sciences | 17 | 2017-01-01 | 2025-03-17 |
| Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced Head and Neck Cancer Stereotactic Body Radiation Therapy, Positron Emission Tomography, Computed Tomography - Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma | Not applicable | Terminated | Case Comprehensive Cancer Center | 3 | 2015-03-03 | 2019-01-24 |
| Ganetespib Window of Opportunity Study in Head and Neck Cancers Ganetespib, Therapeutic Conventional Surgery, Laboratory Biomarker Analysis - Stage I Hypopharyngeal Squamous Cell Carcinoma, Stage I Laryngeal Squamous Cell Carcinoma | Phase 1 | Terminated | Emory University | 3 | 2014-12-01 | 2016-07-26 |
| Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer Cisplatin, IMRT 6 weeks, IMRT 5 weeks - Stage III Oropharyngeal Squamous Cell Carcinoma, Stage IVA Oropharyngeal Squamous Cell Carcinoma | Phase 2 | Completed | NRG Oncology | 316 | 2014-10-01 | 2026-05-22 |
| Radiation Therapy and Docetaxel in Treating Patients With HPV-Related Oropharyngeal Cancer Docetaxel, Hyperfractionation, Intensity-Modulated Radiation Therapy - Human Papillomavirus Infection, Stage I Oropharyngeal Squamous Cell Carcinoma | Phase 2 | Completed | Mayo Clinic | 81 | 2013-09-04 | 2026-02-10 |
| Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer Dexamethasone, Placebo, Quality-of-Life Assessment - Dysphagia, Pain | Not applicable | Completed | OHSU Knight Cancer Institute | 76 | 2012-12-01 | 2018-06-19 |
| Soy Isoflavones in Preventing Head and Neck Cancer Recurrence in Patients With Stage I-IV Head and Neck Cancer Undergoing Surgery Laboratory Biomarker Analysis, Soy Isoflavones, Survey Administration - Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 55 | 2009-07-01 | 2016-10-24 |
Squamous Cell Carcinoma of Head and Neck (9) · Lymphoid Interstitial Pneumonia (2) · Papillomavirus Infections (2) · Tongue Neoplasms (2) · Deglutition Disorders (1) · Head and Neck Neoplasms (1) · Pain (1)
Carcinoma (9) · Carcinoma, Squamous Cell (9) · Neoplasms (9) · Neoplasms by Histologic Type (9) · Neoplasms by Site (9) · Neoplasms, Glandular and Epithelial (9) · Head and Neck Neoplasms (8) · Pathological Conditions, Signs and Symptoms (3) · Communicable Diseases (2) · DNA Virus Infections (2) · Disease Attributes (2) · Genital Diseases (2) · Infections (2) · Mouth Diseases (2) · Mouth Neoplasms (2)
Radiotherapy, Intensity-Modulated (2) · Calcium Dobesilate (1) · Carboplatin (1) · Cisplatin (1) · Dexamethasone (1) · Disulfides (1) · Docetaxel (1) · Educational Status (1) · Immunoglobulin G (1) · Methods (1) · Nivolumab (1) · Paclitaxel (1) · Positron-Emission Tomography (1) · Radiosurgery (1) · STA 9090 (1)
Wake Forest University Health Sciences (2) · Case Comprehensive Cancer Center (1) · Emory University (1) · Mayo Clinic (1) · NRG Oncology (1) · National Cancer Institute (NCI) (1) · OHSU Knight Cancer Institute (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1)
United States (9) · Canada (1) · Ireland (1) · Saudi Arabia (1)
Chandylen Nightingale (1) · Daniel Clayburgh (1) · Daniel Ma (1) · Greg Wolf (1) · Jennifer Johnson, MD, PhD (1) · Mercedes Porosnicu (1) · Nabil F. Saba, MD (1) · Shlomo Koyfman (1) · Sue Yom (1)
PMID 28850681, PMID 31163012, PMID 33507809, PMID 35575280
P30CA012197 (2), P30CA043703 (1), P30CA046592 (1), P30CA069533 (1), R03CA208560 (1), U10CA180868 (1)