5 completed, 2 unknown, 1 withdrawn. 8 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 5, Unknown 2, Withdrawn 1 |
| Phase 1 | 3 | Completed 3 |
Follow Smith-Lemli-Opitz Syndrome: new trials by email Literature Review of Smith-Lemli-Opitz Syndrome trials Research Report on Smith-Lemli-Opitz Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Smith-Lemli-Opitz Syndrome and Cholic Acid Cholic Acid - Smith-Lemli-Opitz Syndrome | Phase 1 / Phase 2 | Completed | University of Nebraska | 12 | 2021-03-27 | 2024-04-30 |
| Novel Treatment for Syndromic Ichthyoses Lovastatin - Syndromic Ichthyoses, CHILD Syndrome | Phase 2 | Withdrawn | Northwestern University | 2011-07-01 | 2015-05-19 | |
| Cholesterol in ASD: Characterization and Treatment Cholesterol - Autism, Asperger Disorder | Phase 1 / Phase 2 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 44 | 2009-07-28 | 2018-07-05 |
| Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS) Antioxidants, Cholesterol - Smith-Lemli-Opitz Syndrome, Cone-Rod Dystrophy | Phase 2 | Unknown | University of Colorado, Denver | 100 | 2008-12-01 | 2024-05-08 |
| Short-term Behavioral Effects of Cholesterol Therapy in Smith-Lemli-Opitz Syndrome Egg yolk preparation with cholesterol, Egg substitute, without cholesterol - Smith-Lemli-Opitz Syndrome | Phase 2 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 13 | 2005-06-01 | 2016-01-29 |
| Simvastatin Therapy in Smith-Lemli-Opitz Syndrome Simvastatin Susp., OraPlus - Smith-Lemli-Opitz Syndrome | Phase 2 | Completed | Forbes Porter, M.D. | 23 | 2003-07-01 | 2014-06-06 |
| Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome crystalline cholesterol oil-based suspension - Smith-Lemli-Opitz Syndrome | Phase 1 / Phase 2 | Completed | Boston Children's Hospital | 23 | 1998-01-01 | 2017-10-20 |
| Phase II Study of Dietary Cholesterol for Smith-Lemli-Opitz Syndrome diet - Smith-Lemli-Opitz Syndrome | Phase 2 | Unknown | National Center for Research Resources (NCRR) | 5 | 1995-11-01 | 2005-06-24 |
Intellectual Disability (2) · Asperger Syndrome (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Child Development Disorders, Pervasive (1) · Cone-Rod Dystrophies (1) · Congenital Abnormalities (1) · Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects (1) · Genetic Diseases, Inborn (1) · Hearing Loss (1) · Rare Diseases (1)
Abnormalities, Multiple (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Dyslipidemias (8) · Lipid Metabolism Disorders (8) · Lipid Metabolism, Inborn Errors (8) · Metabolic Diseases (8) · Metabolism, Inborn Errors (8) · Nutritional and Metabolic Diseases (8) · Steroid Metabolism, Inborn Errors (8) · Congenital Abnormalities (7) · Genetic Diseases, Inborn (7) · Pathological Conditions, Signs and Symptoms (4) · Mental Disorders (3) · Nervous System Diseases (3) · Neurodevelopmental Disorders (3)
Cholesterol (3) · Antioxidants (1) · Cholic Acid (1) · Diet (1) · Eggs (1) · Lovastatin (1)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Boston Children's Hospital (1) · Forbes Porter, M.D. (1) · National Center for Research Resources (NCRR) (1) · Northwestern University (1) · University of Colorado, Denver (1) · University of Nebraska (1)
United States (7)
Ellen R Elias, MD (2) · Forbes D Porter, M.D. (2) · Amy S Paller, MD (1) · Forbes D Porter, MD (1) · Mira Irons, M.D. (1) · William B Rizzo, MD (1) · William Connor (1)
PMID 14605787, PMID 14662594, PMID 27053961, PMID 8209913, PMID 9024564, PMID 9024565