10 completed, 3 terminated, 3 unknown, 1 active not recruiting. 6 Phase 1, 5 Phase 2, 3 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 5, Terminated 1 |
| Phase 2 | 5 | Completed 3, Unknown 2 |
| Not applicable | 3 | Completed 2, Terminated 1 |
| Phase 4 | 1 | Completed 1 |
Follow Scleritis: new trials by email Literature Review of Scleritis trials Research Report on Scleritis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Demographics and Clinical Characteristics of Ocular Inflammatory Diseases in Singapore No Intervention: Observational Cohort - Uveitis, Scleritis and Episcleritis | Active not recruiting | Singapore National Eye Centre | 200 | 2025-08-19 | 2025-09-16 | |
| AutoInflammatory Disease Alliance Registry (AIDA) No intervention is foreseen by the protocol. - Hereditary Autoinflammatory Diseases, Schnitzler Syndrome | Recruiting | University of Siena | 3500 | 2020-08-06 | 2025-07-10 | |
| Tofacitinib for Inflammatory Eye Disease tofacitinib - Uveitis, Scleritis | Phase 2 | Unknown | Washington University School of Medicine | 5 | 2019-04-04 | 2021-02-01 |
| A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis ACTH (adrenocorticotropic hormone) gel - Scleritis | Phase 2 | Unknown | Metropolitan Eye Research & Surgery Institute | 30 | 2019-01-01 | 2023-10-23 |
| LSFG-SKIN, Laser Speckle Flowgraphy laser speckle flowgraphy - Hypertension, Heart Failure | Not applicable | Terminated | Randy Kardon | 1 | 2017-05-23 | 2023-05-10 |
| Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients H.P. ACTHAR SUBCUTANEOUS GEL INJECTION - Uveitis, Anterior Uveitis | Phase 4 | Completed | Tampa Bay Uveitis Center, LLC | 6 | 2016-06-30 | 2018-07-02 |
| Ocular Manifestations in Rheumatic Diseases No intervention used - Uveitis, Conjunctivitis | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 5000 | 2013-05-01 | 2022-04-12 | |
| Gevokizumab for Active Scleritis Gevokizumab - Scleritis | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 8 | 2013-03-01 | 2018-07-06 |
| Optical Coherence Tomography in the Diagnosis of Scleritis and Episcleritis Optical Coherence Tomography - Scleritis and Episcleritis | Not applicable | Completed | The Eye Center and The Eye Foundation for Research in Ophthalmology | 32 | 2012-07-01 | 2014-09-01 |
| Causes of Visual Loss in Retinal Disease Immunosuppressive Agents - Uveitis, Scleritis | Unknown | Royal Surrey County Hospital NHS Foundation Trust | 2000 | 2012-05-01 | 2012-06-07 | |
| Sirolimus Injections for Autoimmune Scleritis Sirolimus - Scleritis | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 5 | 2012-01-01 | 2020-06-19 |
| Iontophoresis Delivery of Dexamethasone Phosphate for Non-infectious, Non-necrotizing Anterior Scleritis, Phase 1 Dose-varying Study Dexamethasone Phosphate Ophthalmic Solution (EGP-437), Dexamethasone phosphate ophthalmic solution - Non-infectious, Non-necrotizing Anterior Scleritis | Phase 1 | Completed | John Kempen | 18 | 2012-01-01 | 2016-04-21 |
| Perichondrium Autograft in Refractory Necrotizing Scleritis Perichondrium Autografts - Necrotizing Scleritis | Not applicable | Completed | Chung-Ang University Hospital | 20 | 2011-03-01 | 2016-08-12 |
| Human Samples and Data Repository Uveitis, Scleritis | Terminated | National Eye Institute (NEI) | 1862 | 2007-08-29 | 2022-08-26 | |
| Rituximab in the Treatment of Scleritis and Non-Infectious Orbital Inflammation Rituximab - Scleritis, Orbital Disease | Phase 1 / Phase 2 | Completed | Oregon Health and Science University | 20 | 2007-01-01 | 2013-08-16 |
| Study Evaluating PSI-697 in Patients With Scleritis PSI-697 - Scleritis | Phase 1 | Terminated | Wyeth is now a wholly owned subsidiary of Pfizer | 12 | 2006-09-01 | 2009-09-09 |
| Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study Uveitis, Cancer | Completed | National Eye Institute (NEI) | 6300 | 2005-06-16 | 2017-07-02 | |
| Infliximab to Treat Non-Infectious Scleritis Infliximab - Scleritis | Phase 1 | Completed | National Eye Institute (NEI) | 5 | 2003-12-23 | 2017-07-02 |
Uveitis (9) · Neoplasms (2) · Orbital Diseases (2) · Uveitis, Intermediate (2) · Uveitis, Posterior (2) · Amaurosis Fugax (1) · Arthritis, Juvenile (1) · Behcet Syndrome (1) · Blindness (1) · Burns (1) · Castleman Disease (1) · Chorioretinitis (1) · Choroid Hemorrhage (1) · Conjunctivitis (1)
Eye Diseases (18) · Scleral Diseases (18) · Uveal Diseases (9) · Panuveitis (4) · Cardiovascular Diseases (3) · Immune System Diseases (3) · Vascular Diseases (3) · Autoimmune Diseases (2) · Hemic and Lymphatic Diseases (2) · Hemorrhage (2) · Immunoproliferative Disorders (2) · Lymphatic Diseases (2) · Lymphoproliferative Disorders (2) · Nervous System Diseases (2) · Neurologic Manifestations (2)
Adrenocorticotropic Hormone (2) · Infliximab (2) · Rituximab (2) · 2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo(H)quinoline-4-carboxylic acid (1) · 5-(tetradecyloxy)-2-furancarboxylic acid (1) · Adalimumab (1) · Azathioprine (1) · Cyclosporine (1) · Etanercept (1) · Gels (1) · Immunosuppressive Agents (1) · Methotrexate (1) · Mycophenolic Acid (1) · Prednisolone (1) · Sirolimus (1)
National Eye Institute (NEI) (5) · Chung-Ang University Hospital (1) · John Kempen (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Metropolitan Eye Research & Surgery Institute (1) · Oregon Health and Science University (1) · Randy Kardon (1) · Royal Surrey County Hospital NHS Foundation Trust (1) · Singapore National Eye Centre (1) · Tampa Bay Uveitis Center, LLC (1) · The Eye Center and The Eye Foundation for Research in Ophthalmology (1) · University of Siena (1) · Washington University School of Medicine (1) · Wyeth is now a wholly owned subsidiary of Pfizer (1)
United States (11) · Saudi Arabia (2) · Algeria (1) · Australia (1) · Belgium (1) · Brazil (1) · China (1) · Colombia (1) · Egypt (1) · Germany (1) · Greece (1) · India (1) · Iran (1) · Italy (1) · Libya (1)
Hatice N Sen, M.D. (3) · David K Scales, MD (1) · David S. Chu, MD (1) · Eric B Suhler, MD (1) · Grace L Clarke (1) · Jae Chan Kim, Ph.D. (1) · James T Rosenbaum, MD (1) · Janet Pope, MD (1) · Jee Taek Kim, Ph.D. (1) · Lynn M Hassman, MD PhD (1) · Quan D Nguyen, MD, MSc (1) · Simon RJ Taylor, PhD FRCOphth (1)
PMID 24652467, PMID 25526946, PMID 27663070, PMID 29666122, PMID 35463015, PMID 35755024, PMID 35831701, PMID 35899212, PMID 35935379, PMID 36160138, PMID 36881285, PMID 37517110, PMID 38206518, PMID 39886503, PMID 40175882, PMID 42444147