4 recruiting, 2 completed, 1 terminated, 1 unknown. 4 Phase 1, 4 Phase 2, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Recruiting 2, Completed 1, Terminated 1 |
| Phase 2 | 4 | Recruiting 2, Completed 1, Terminated 1 |
| Not applicable | 2 | Recruiting 1, Unknown 1 |
Follow Relapsed Pediatric ALL: new trials by email Literature Review of Relapsed Pediatric ALL trials Research Report on Relapsed Pediatric ALL
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma Anti-Thymocyte Globulin (Rabbit), Cyclophosphamide, Fludarabine - Relapsed Pediatric ALL, Hematopoietic Cell Transplantation | Phase 1 | Recruiting | St. Jude Children's Research Hospital | 70 | 2026-10-03 | 2026-08-28 |
| Bridging Allogeneic Hematopoietic Stem Cell Transplantation or Not After CD19 CAR - T (S1904) Cell Therapy for r/r B-cell Acute Lymphoblastic Leukemia Senl_B19 autologous CAR-T (S1904) treatment - Relapsed Adult ALL, B-cell Acute Lymphoblastic Leukemia | Not applicable | Recruiting | Peking University People's Hospital | 130 | 2024-10-01 | 2025-03-12 |
| A Study of pCAR-19B in the Treatment of CD19-positive Relapsed/Refractory B-ALL in Children and Adolescents pCAR-19B cells - Acute Lymphoblastic Leukemia, Relapsed Pediatric ALL | Phase 2 | Recruiting | Chongqing Precision Biotech Co., Ltd | 100 | 2022-01-26 | 2026-09-15 |
| Anti-CD19, Dual Co-stimulatory (4-1BB, CD3ζ) Chimeric Antigen Receptor T-cells in Patients With Relapsed/Refractory Aggressive Lymphoma or Acute Lymphoblastic Leukemia (ALL) autologous CD19-directed chimeric antigen receptor (CAR) T-cells - Relapsed Non Hodgkin Lymphoma, Relapsed Adult ALL | Phase 1 / Phase 2 | Recruiting | University of Alberta | 63 | 2021-03-03 | 2026-02-09 |
| TCDαβ/CD45RA Haploidentical Transplantation in Children With Leukemia In Vitro T cells depletion using CliniMCAS system - Relapsed Pediatric ALL, Acute Graft-Versus-Host Disease (Gvhd) Grade IV (Diagnosis) | Not applicable | Unknown | Shanghai Children's Medical Center | 30 | 2020-11-10 | 2022-09-29 |
| Low Dose Daunorubicin in Pediatric Relapsed/Refractory Acute Leukemia Daunorubicin - Relapsed Pediatric ALL, Relapsed Pediatric AML | Phase 2 | Completed | Children's Mercy Hospital Kansas City | 1 | 2020-05-08 | 2023-06-28 |
| Phase I Study of pCAR-19B in the Treatment of CD19-positive Relapsed/Refractory B-ALL in Children and Adolescents pCAR-19B cells - Acute Lymphoblastic Leukemia, Relapsed Pediatric ALL | Phase 1 | Completed | Chongqing Precision Biotech Co., Ltd | 9 | 2019-11-05 | 2022-03-18 |
| ABT-751 With Chemotherapy for Relapsed Pediatric ALL ABT-751, Dexamethasone, PEG-asparaginase - Recurrent Pediatric ALL, Relapsed Pediatric ALL | Phase 1 / Phase 2 | Terminated | Therapeutic Advances in Childhood Leukemia Consortium | 9 | 2006-05-22 | 2021-03-17 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma (8) · Recurrence (2) · Burkitt Lymphoma (1) · Disease (1) · Graft vs Host Disease (1) · Hematologic Neoplasms (1) · Leukemia (1) · Leukemia, Myeloid, Acute (1) · Lymphoma, Non-Hodgkin (1)
Hematologic Diseases (8) · Hemic and Lymphatic Diseases (8) · Immune System Diseases (8) · Immunoproliferative Disorders (8) · Leukemia, Lymphoid (8) · Lymphatic Diseases (8) · Lymphoproliferative Disorders (8) · Neoplasms (8) · Neoplasms by Histologic Type (8) · Leukemia (7) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Disease Attributes (2) · Lymphoma (2) · DNA Virus Infections (1)
Cyclophosphamide (2) · ABT751 (1) · Antilymphocyte Serum (1) · Antineoplastic Agents (1) · Asparaginase (1) · Automobiles (1) · Calcium Dobesilate (1) · Cytarabine (1) · Daunorubicin (1) · Dexamethasone (1) · Doxorubicin (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Melphalan (1) · Mesna (1)
Chongqing Precision Biotech Co., Ltd (2) · Children's Mercy Hospital Kansas City (1) · Peking University People's Hospital (1) · Shanghai Children's Medical Center (1) · St. Jude Children's Research Hospital (1) · Therapeutic Advances in Childhood Leukemia Consortium (1) · University of Alberta (1)
China (4) · United States (3) · Canada (1)
Chandni Dargan, MD (1) · Dr. Michael P Chu, MD (1) · Jianfeng Zhou, M.D. Ph.D (1) · Jing Chen (1) · Paul S Gaynon, MD (1) · Swati Naik, MBBS (1) · Tianyou Wang, M.D. Ph.D (1) · Yicheng Zhang, M.D. Ph.D (1)