8 completed, 4 terminated. 10 Phase 2, 7 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 6, Terminated 4 |
| Phase 1 | 7 | Terminated 4, Completed 3 |
Follow this drug Literature Review of ABT751 trials Research Report on ABT751
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Study Evaluating ABT-751 in Combination With Taxotere in Advanced Non-Small Cell Lung Cancer ABT-751, Placebo, Docetaxel - Lung Cancer, Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Terminated | Abbott | 75 | 2007-02-01 | 2011-01-07 |
| ABT-751 in Treating Children With Neuroblastoma That Has Relapsed or Not Responded to Previous Treatment ABT-751, quality-of-life assessment - Disseminated Neuroblastoma, Recurrent Neuroblastoma | Phase 2 | Completed | Children's Oncology Group | 92 | 2007-01-01 | 2019-07-17 |
| A Phase 1/2 Study Evaluating ABT-751 in Combination With Alimta in Advanced Non-Small Cell Lung Cancer ABT-751, pemetrexed, placebo - Lung Cancer, NSCLC | Phase 1 / Phase 2 | Completed | AbbVie (prior sponsor, Abbott) | 165 | 2006-11-01 | 2013-01-31 |
| ABT-751 With Chemotherapy for Relapsed Pediatric ALL ABT-751, Dexamethasone, PEG-asparaginase - Recurrent Pediatric ALL, Relapsed Pediatric ALL | Phase 1 / Phase 2 | Terminated | Therapeutic Advances in Childhood Leukemia Consortium | 9 | 2006-05-22 | 2021-03-17 |
| Pharmacokinetic & Pharmacodynamic Study of ABT-751 With Carboplatin in Patients With Advanced Lung Cancer ABT-751 and Carboplatin - Non Small Cell Lung Cancer, Lung Cancer | Phase 1 / Phase 2 | Terminated | Konstantin Dragnev | 20 | 2004-09-01 | 2018-10-12 |
| ABT-751 in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy ABT-751 - Prostate Cancer | Phase 1 / Phase 2 | Terminated | Vanderbilt-Ingram Cancer Center | 27 | 2004-01-01 | 2012-07-11 |
| A Study of ABT-751 in Patients With Non-Small Cell Lung Cancer ABT-751 - Non-Small Cell Lung Cancer | Phase 2 | Completed | Abbott | 30 | 2003-09-01 | 2007-11-29 |
| A Study of ABT-751 in Patients With Colorectal Cancer ABT-751 - Colorectal Cancer | Phase 2 | Completed | Abbott | 40 | 2003-08-01 | 2007-11-29 |
| A Study of ABT-751 in Patients With Renal Cell Cancer ABT-751 - Renal Cell Cancer | Phase 2 | Completed | Abbott | 60 | 2003-08-01 | 2007-11-29 |
| Study of ABT-751 in Patients With Refractory Hematologic Malignancies ABT-751 - Hematological Malignancies | Phase 1 | Completed | M.D. Anderson Cancer Center | 32 | 2002-12-01 | 2018-10-31 |
| A Study of ABT-751 in Patients With Recurrent Breast Cancer After Taxane (Taxol or Taxotere) Therapy. ABT-751 - Breast Cancer | Phase 2 | Completed | Abbott | 40 | 2002-11-01 | 2007-11-29 |
| ABT-751 in Treating Young Patients With Refractory Solid Tumors ABT-751 - Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 90 | 2002-03-01 | 2012-03-15 |
Carcinoma, Non-Small-Cell Lung (4) · Lung Neoplasms (3) · Neuroblastoma (2) · Astrocytoma (1) · Breast Neoplasms (1) · Carcinoma, Renal Cell (1) · Central Nervous System Neoplasms (1) · Choroid Plexus Neoplasms (1) · Colorectal Neoplasms (1) · Familial ependymoma (1) · Hematologic Neoplasms (1) · Kidney Neoplasms (1) · Liver Neoplasms (1) · Medulloblastoma (1) · Neuroectodermal Tumors, Primitive, Peripheral (1)
Abbott (5) · AbbVie (prior sponsor, Abbott) (1) · Children's Oncology Group (1) · Konstantin Dragnev (1) · M.D. Anderson Cancer Center (1) · National Institutes of Health Clinical Center (CC) (1) · Therapeutic Advances in Childhood Leukemia Consortium (1) · Vanderbilt-Ingram Cancer Center (1)
United States (12) · Canada (3) · Czechia (1) · Greece (1) · Hungary (1) · Ireland (1) · Netherlands (1) · Slovakia (1) · United Kingdom (1)
Helen Eliopoulos, MD (4) · Elizabeth Fox, MD (2) · Francis J. Giles, MD (1) · Gary Gordon, MD (1) · Helen Eliopoulos, M.D. (1) · Jeff Sosman, MD (1) · Konstantin H Dragnev, MD (1) · Paul S Gaynon, MD (1)
PMID 16914576, PMID 18281544, PMID 20044751, PMID 21300929, PMID 23147218
U10CA098543 (1)