8 active not recruiting, 3 completed, 1 recruiting. 10 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Active not recruiting 6, Completed 3, Recruiting 1 |
| Phase 1 | 3 | Active not recruiting 2, Recruiting 1 |
Follow Refractory Malignant Glioma: new trials by email Literature Review of Refractory Malignant Glioma trials Research Report on Refractory Malignant Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors LUTATHERA® (Lutetium Lu 177 dotatate) - High Grade Glioma, Meningioma | Phase 1 / Phase 2 | Recruiting | Nationwide Children's Hospital | 65 | 2022-11-21 | 2026-07-20 |
| Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography - Hematopoietic and Lymphatic System Neoplasm, Recurrent Ependymoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 1 | 2021-05-03 | 2026-10-09 |
| Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial Tipifarnib - Malignant Solid Neoplasm, Recurrent Adrenal Gland Pheochromocytoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 5 | 2020-10-13 | 2026-10-16 |
| Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial) Ivosidenib - Recurrent Ependymoma, Recurrent Ewing Sarcoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 3 | 2020-07-20 | 2026-07-01 |
| Savolitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors Biospecimen Collection, Magnetic Resonance Imaging, Savolitinib - Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Malignant Glioma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 41 | 2018-11-27 | 2026-07-30 |
| Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) Laboratory Biomarker Analysis, Palbociclib, Pharmacological Study - Advanced Malignant Solid Neoplasm, Recurrent Childhood Ependymoma | Phase 2 | Completed | National Cancer Institute (NCI) | 23 | 2018-08-13 | 2026-04-03 |
| Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan - Advanced Malignant Solid Neoplasm, Recurrent Childhood Ependymoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 20 | 2018-06-05 | 2026-10-16 |
| Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial) Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan - Advanced Malignant Solid Neoplasm, Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 13 | 2018-04-17 | 2026-10-28 |
| Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) Tazemetostat - Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Hodgkin Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 20 | 2017-11-13 | 2026-04-13 |
| Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) Olaparib - Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 6 | 2017-09-14 | 2024-12-11 |
| Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial) Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan - Advanced Malignant Solid Neoplasm, Recurrent Ependymoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 9 | 2017-08-23 | 2026-06-17 |
| Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma Arm 1: IL13Ra2-specific CAR Tcm cells, Arm 2: IL13Ra2-specific CAR Tcm cells, Arm 3: IL13Ra2-specific CAR Tcm cells - Recurrent Glioblastoma, Recurrent Malignant Glioma | Phase 1 | Active not recruiting | City of Hope Medical Center | 65 | 2015-06-03 | 2026-11-04 |
Glioma (12) · Medulloblastoma (11) · Ependymoma (10) · Hepatoblastoma (9) · Histiocytosis, Langerhans-Cell (9) · Lymphoma, Non-Hodgkin (9) · Neuroblastoma (9) · Neuroectodermal Tumors, Primitive, Peripheral (9) · Rhabdoid Tumor (9) · Wilms Tumor (9) · Osteosarcoma (8) · Rhabdomyosarcoma (8) · Sarcoma (8) · Central Nervous System Neoplasms (7) · Sarcoma, Ewing (5)
Neoplasms (12) · Neoplasms by Histologic Type (12) · Neoplasms, Glandular and Epithelial (12) · Neoplasms, Nerve Tissue (12) · Neoplasms, Neuroepithelial (12) · Neuroectodermal Tumors (12) · Neoplasms by Site (11) · Neoplasms, Germ Cell and Embryonal (11) · Neuroectodermal Tumors, Primitive (11) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Female Urogenital Diseases (9) · Female Urogenital Diseases and Pregnancy Complications (9) · Genetic Diseases, Inborn (9) · Hemic and Lymphatic Diseases (9) · Histiocytosis (9)
Magnetic Resonance Spectroscopy (6) · Phantoms, Imaging (5) · X-Rays (5) · Nuclear Medicine Department, Hospital (4) · Specimen Handling (4) · Biopsy (3) · 1-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-(1,2,3)triazolo(4,5-b)pyrazine (1) · ensartinib (1) · erdafitinib (1) · ivosidenib (1) · larotrectinib (1) · lutetium Lu 177 dotatate (1) · olaparib (1) · palbociclib (1) · selpercatinib (1)
National Cancer Institute (NCI) (10) · City of Hope Medical Center (1) · Nationwide Children's Hospital (1)
United States (12) · Puerto Rico (9) · Australia (3) · Canada (2)
Alice Lee (1) · Andrea T Franson (1) · Behnam Badie (1) · Christine A Pratilas (1) · Elizabeth D Alva (1) · Julia Glade-Bender (1) · Katherine A Janeway (1) · Margot Lazow, MD (1) · Meredith S Irwin (1) · Rajen Mody (1) · Ralph Salloum (1) · Susan N Chi (1)
PMID 31401903, PMID 28029927, PMID 34486544, PMID 38454126, PMID 38815151, PMID 39298716, PMID 42853672, PMID 42867148
U10CA180886 (9), UM1CA081457 (2), P30CA033572 (1)