25 completed, 23 active not recruiting, 13 recruiting, 4 suspended. 38 Phase 1, 37 Phase 2, 5 Not applicable, 1 Phase 3.
Follow Recurrent Malignant Solid Neoplasm: new trials by email Literature Review of Recurrent Malignant Solid Neoplasm trials Research Report on Recurrent Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adoption of Audio Recording in the Outpatient Supportive Care Center Communication Intervention, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm | Not yet recruiting | M.D. Anderson Cancer Center | 200 | 2026-12-30 | 2026-07-16 | |
| Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors Biopsy, Biospecimen Collection, Computed Tomography - Metastatic Malignant Solid Neoplasm, Metastatic Melanoma | Phase 1 | Recruiting | Anusha Kalbasi | 18 | 2025-10-07 | 2026-03-17 |
| Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma Bcl-XL Proteolysis Targeting Chimera DT2216, Biospecimen Collection, Irinotecan - Childhood Fibrolamellar Carcinoma, Recurrent Childhood Fibrolamellar Carcinoma | Phase 1 / Phase 2 | Suspended | Children's Oncology Group | 81 | 2025-06-12 | 2026-08-24 |
| Studying TAK-243 in Patients With Advanced Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Lymphoma, Advanced Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 95 | 2025-03-24 | 2026-10-13 |
| Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors Axatilimab, Biopsy, Biospecimen Collection - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 / Phase 2 | Recruiting | OHSU Knight Cancer Institute | 38 | 2024-05-21 | 2026-07-08 |
| Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial) Biopsy Procedure, Biospecimen Collection, Computed Tomography - Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm | Phase 2 | Recruiting | National Cancer Institute (NCI) | 70 | 2024-05-07 | 2026-10-19 |
| Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform Biospecimen Collection, Tissue Collection - Early Stage Triple-Negative Breast Carcinoma, Metastatic Bladder Urothelial Carcinoma | Recruiting | Mayo Clinic | 324 | 2024-04-24 | 2026-03-12 | |
| Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study Non-Interventional Study - Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma | Recruiting | University of Washington | 2000 | 2024-01-02 | 2026-04-17 | |
| Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial Alpelisib, Binimetinib, Biopsy Procedure - Advanced Malignant Solid Neoplasm, Anatomic Stage III Breast Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 2900 | 2023-04-07 | 2026-10-15 |
| Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors Atezolizumab, Biospecimen Collection, Computed Tomography - Atypical Teratoid/Rhabdoid Tumor, Epithelioid Sarcoma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 86 | 2022-11-17 | 2026-07-14 |
| Does the Use of a Genomic Tumor Board Increase the Number of Patients Who Receive Genome-Informed Treatment Best Practice, Chart Abstraction, Educational Intervention - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Not applicable | Active not recruiting | SWOG Cancer Research Network | 1284 | 2022-10-14 | 2026-01-22 |
| BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors Copanlisib, Elimusertib - Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Bone | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2022-03-22 | 2022-05-27 | |
| Testing the Combination of ZEN003694 and Nivolumab With or Without Ipilimumab in Solid Tumors BET Bromodomain Inhibitor ZEN-3694, Biopsy Procedure, Biospecimen Collection - Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm | Phase 1 | Suspended | National Cancer Institute (NCI) | 66 | 2022-02-02 | 2026-08-17 |
| CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma Biospecimen Collection, Bone Marrow Aspirate, Bone Marrow Biopsy - Diffuse Midline Glioma, H3 K27-Altered, Metastatic Malignant Neoplasm in the Central Nervous System | Phase 1 / Phase 2 | Recruiting | Children's Oncology Group | 63 | 2022-01-28 | 2026-09-11 |
| Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors Elimusertib - Recurrent Alveolar Rhabdomyosarcoma, Recurrent Ewing Sarcoma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 31 | 2021-12-22 | 2026-01-23 |
| Parenting Support Intervention for Families Coping With Metastatic or Locally Recurrent Solid Tumor Diagnosis Best Practice, Educational Intervention, Questionnaire Administration - Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm | Not applicable | Recruiting | M.D. Anderson Cancer Center | 120 | 2021-11-30 | 2026-09-25 |
| Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV Biospecimen Collection, Cabozantinib S-malate, Computed Tomography - Advanced Differentiated Thyroid Gland Carcinoma, Advanced Head and Neck Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 8 | 2021-11-22 | 2026-05-28 |
| Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors Biospecimen Collection, Dual X-ray Absorptiometry, Tegavivint - Colorectal Carcinoma, Endometrial Carcinoma | Phase 1 / Phase 2 | Recruiting | Children's Oncology Group | 147 | 2021-11-08 | 2026-08-25 |
| Financial Navigation Program to Improve Understanding and Management of Financial Aspects of Cancer Care for Patients and Their Spouses Educational Intervention, Patient Navigation, Quality-of-Life Assessment - Hematopoietic and Lymphoid Cell Neoplasm, Metastatic Malignant Solid Neoplasm | Not applicable | Active not recruiting | SWOG Cancer Research Network | 331 | 2021-10-12 | 2026-05-14 |
| Frequency of Cachexia in Ambulatory Cancer Patients and Psychological Burden in Patients and Their Primary Caregivers Questionnaire Administration - Advanced Malignant Solid Neoplasm, Caregiver | Active not recruiting | M.D. Anderson Cancer Center | 192 | 2021-06-22 | 2026-08-06 |
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Neoplasm Metastasis (31) · Central Nervous System Neoplasms (19) · Neuroblastoma (19) · Glioma (15) · Neuroectodermal Tumors, Primitive, Peripheral (15) · Osteosarcoma (15) · Rhabdomyosarcoma (15) · Sarcoma (15) · Hepatoblastoma (14) · Lymphoma, Non-Hodgkin (14) · Wilms Tumor (14) · Rhabdoid Tumor (13) · Lymphoma (12) · Ependymoma (11) · Histiocytosis, Langerhans-Cell (11)
Neoplasms (66) · Neoplasms by Site (47) · Neoplasms by Histologic Type (43) · Neoplasms, Glandular and Epithelial (37) · Neoplasms, Germ Cell and Embryonal (33) · Neoplasms, Nerve Tissue (32) · Neuroectodermal Tumors (32) · Neoplastic Processes (31) · Pathologic Processes (31) · Pathological Conditions, Signs and Symptoms (31) · Hemic and Lymphatic Diseases (30) · Immune System Diseases (28) · Urogenital Diseases (27) · Female Urogenital Diseases (26) · Female Urogenital Diseases and Pregnancy Complications (26)
Specimen Handling (21) · Magnetic Resonance Spectroscopy (17) · Biopsy (14) · X-Rays (10) · Phantoms, Imaging (9) · Nivolumab (7) · Nuclear Medicine Department, Hospital (6) · CTLA-4 Antigen (4) · Early Intervention, Educational (4) · Educational Status (4) · Ipilimumab (4) · Irinotecan (4) · Methods (4) · Temozolomide (4) · cabozantinib (4)
National Cancer Institute (NCI) (34) · M.D. Anderson Cancer Center (16) · Children's Oncology Group (9) · Rutgers, The State University of New Jersey (2) · SWOG Cancer Research Network (2) · University of Washington (2) · Anusha Kalbasi (1) · Jerome Canady, M.D. (1) · Mayo Clinic (1) · National Cancer Institute LAO (1) · OHSU Knight Cancer Institute (1) · St. Jude Children's Research Hospital (1) · University of California, Davis (1) · University of Rochester NCORP Research Base (1)
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Sriram Yennu (3) · Haider S Mahdi (2) · Julia Glade-Bender (2) · Michael V Ortiz (2) · Vivek Subbiah (2) · A P Chen (1) · AeRang Kim (1) · Alice Lee (1) · Allison Betof Warner, MD, PhD (1) · Andrea T Franson (1) · Andrew Bukowinski (1) · Antoni Ribas, MD, PhD (1) · Aung Naing (1) · Aung Naing, MD (1) · Biren Saraiya (1)
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