94 completed, 24 terminated, 5 active not recruiting, 5 withdrawn. 72 Phase 1, 62 Phase 2, 12 Not applicable, 3 Early Phase 1, 3 Phase 3.
Follow Recurrent Grade 3 Follicular Lymphoma: new trials by email Literature Review of Recurrent Grade 3 Follicular Lymphoma trials Research Report on Recurrent Grade 3 Follicular Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CpG-STAT3 siRNA CAS3/SS3 and Localized Radiation Therapy for the Treatment of Relapsed/Refractory B-Cell NHL CpG-STAT3 siRNA CAS3/SS3, Radiation Therapy - Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma | Phase 1 | Withdrawn | City of Hope Medical Center | 2021-07-27 | 2024-04-25 | |
| Nivolumab for Relapsed, Refractory, or Detectable Disease Post Chimeric Antigen Receptor T-cell Treatment in Patients With Hematologic Malignancies Nivolumab - Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma | Phase 2 | Completed | University of Washington | 20 | 2020-06-05 | 2026-06-26 |
| Venetoclax, Carmustine, Etoposide, Cytarabine, and Melphalan Before Stem Cell Transplant in Treating Participants With Relapsed or Refractory Non-Hodgkin Lymphoma Carmustine, Cytarabine, Etoposide - Hematopoietic Cell Transplantation Recipient, Recurrent Diffuse Large B-Cell Lymphoma | Phase 1 / Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 19 | 2018-09-10 | 2025-05-14 |
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22 anti-CD19/22-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | Chinese PLA General Hospital | 30 | 2017-08-01 | 2019-04-17 |
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20 anti-CD19/20-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Chinese PLA General Hospital | 100 | 2017-04-01 | 2020-09-02 |
| Lenalidomide and Blinatumomab for the Treatment of Relapsed Non-Hodgkin Lymphoma Blinatumomab, Lenalidomide - Recurrent Burkitt Lymphoma, Recurrent Diffuse Large B-Cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 35 | 2016-11-15 | 2025-11-26 |
| Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma rituximab, lenalidomide, romidepsin - B-cell Adult Acute Lymphoblastic Leukemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Phase 1 / Phase 2 | Withdrawn | Mayo Clinic | 2016-10-01 | 2016-08-11 | |
| Competitive Transfer of αCD19-TCRz-CD28 and αCD19-TCRz-CD137 CAR-T Cells for B-cell Leukemia/Lymphoma anti-CD19 CAR-T, Fludarabine, Cyclophosphamide - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine | 20 | 2016-02-01 | 2017-03-16 |
| Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas Ibrutinib, Idelalisib, Laboratory Biomarker Analysis - Recurrent B-Cell Non-Hodgkin Lymphoma, Recurrent Chronic Lymphocytic Leukemia | Phase 2 | Completed | Mayo Clinic | 65 | 2015-02-19 | 2026-06-24 |
| Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma carmustine, cytarabine, melphalan - Adult Nasal Type Extranodal NK/T-cell Lymphoma, AIDS-related Diffuse Large Cell Lymphoma | Not applicable | Withdrawn | Fred Hutchinson Cancer Center | 2015-02-01 | 2015-05-07 | |
| CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma 6,8-bis(benzylthio)octanoic acid, bendamustine hydrochloride, rituximab - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia | Phase 1 | Terminated | Wake Forest University Health Sciences | 1 | 2014-12-01 | 2018-07-02 |
| Everolimus and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory Hematologic Cancer everolimus, bendamustine hydrochloride - Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Hodgkin Lymphoma | Phase 1 | Completed | University of California, Davis | 20 | 2014-10-01 | 2019-01-04 |
| Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection Ibrutinib, Laboratory Biomarker Analysis, Pharmacological Study - Adult B Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 72 | 2014-09-01 | 2015-08-20 |
| Study of BKM120 & Rituximab in Patients With Relapsed or Refractory Indolent B-Cell Lymphoma PI3K inhibitor BKM120, rituximab, Pharmacodynamics - Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Nodal Marginal Zone B-cell Lymphoma | Phase 1 | Completed | Kami Maddocks, MD | 18 | 2014-07-21 | 2022-06-30 |
| Lenalidomide and Obinutuzumab in Treating Patients With Relapsed Indolent Non-Hodgkin Lymphoma Laboratory Biomarker Analysis, Lenalidomide, Obinutuzumab - Grade 3a Follicular Lymphoma, Recurrent Follicular Lymphoma | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 66 | 2014-05-27 | 2025-06-24 |
| Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma BTK inhibitor PCI-32765, rituximab, bendamustine hydrochloride - Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Nodal Marginal Zone B-cell Lymphoma | Phase 1 | Active not recruiting | Kami Maddocks, MD | 48 | 2014-03-26 | 2026-07-22 |
| Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant busulfan, etoposide, cyclophosphamide - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 33 | 2014-03-01 | 2015-08-13 |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Morphotek | 27 | 2013-11-01 | 2016-01-08 |
| Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells, autologous hematopoietic stem cell transplantation, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Cutaneous B-cell Non-Hodgkin Lymphoma | Phase 1 | Active not recruiting | City of Hope Medical Center | 30 | 2013-10-08 | 2026-06-25 |
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Lymphoma, Follicular (132) · Lymphoma, Mantle-Cell (121) · Lymphoma, Large B-Cell, Diffuse (118) · Leukemia, Lymphocytic, Chronic, B-Cell (112) · Lymphoma, B-Cell, Marginal Zone (112) · Lymphoma, Non-Hodgkin (102) · Burkitt Lymphoma (96) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (92) · Lymphoma, Large-Cell, Immunoblastic (89) · Waldenstrom Macroglobulinemia (86) · Mycosis Fungoides (69) · Sezary Syndrome (69) · Hodgkin Disease (68) · Lymphoma, T-Cell, Cutaneous (67) · Lymphoma, Large-Cell, Anaplastic (64)
Hemic and Lymphatic Diseases (132) · Immune System Diseases (132) · Immunoproliferative Disorders (132) · Lymphatic Diseases (132) · Lymphoma (132) · Lymphoproliferative Disorders (132) · Neoplasms by Histologic Type (132) · Neoplasms (130) · Lymphoma, B-Cell (123) · Hematologic Diseases (120) · Leukemia (116) · Leukemia, Lymphoid (116) · Disease Attributes (113) · Pathologic Processes (113) · Pathological Conditions, Signs and Symptoms (113)
Rituximab (24) · Peripheral Blood Stem Cell Transplantation (22) · fludarabine phosphate (18) · Whole-Body Irradiation (16) · Cyclophosphamide (15) · Mycophenolic Acid (15) · Cyclosporine (12) · Etoposide (12) · Filgrastim (10) · Granulocyte Colony-Stimulating Factor (10) · Bortezomib (9) · Tacrolimus (9) · Flow Cytometry (8) · Lenalidomide (8) · Vorinostat (8)
National Cancer Institute (NCI) (54) · Fred Hutchinson Cancer Center (23) · City of Hope Medical Center (7) · Mayo Clinic (7) · Case Comprehensive Cancer Center (6) · Roswell Park Cancer Institute (5) · Chinese PLA General Hospital (4) · University of Washington (3) · Kami Maddocks, MD (2) · Ohio State University Comprehensive Cancer Center (2) · Wake Forest University Health Sciences (2) · Amir Mortazavi (1) · Barbara Ann Karmanos Cancer Institute (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · M.D. Anderson Cancer Center (1)
United States (123) · Italy (7) · China (5) · Canada (4) · Germany (4) · Denmark (1) · Singapore (1)
Ajay Gopal (6) · David Maloney (5) · Brenda Sandmaier (4) · Kami Maddocks, MD (3) · Paul Martin (3) · Sonali Smith (3) · Thomas Witzig (3) · Anas Younes (2) · Brenda Cooper (2) · George Chen (2) · John Gerecitano (2) · Leslie Popplewell (2) · Patricia LoRusso (2) · Philip McCarthy (2) · Ramesh Ramanathan (2)
PMID 32499241, PMID 34515338, PMID 27118452, PMID 18256325, PMID 18974373, PMID 19900571, PMID 20837940, PMID 21073974, PMID 21300924, PMID 21508413, PMID 21725056, PMID 22259028, PMID 23256542, PMID 24241210, PMID 24474568, PMID 24530971, PMID 25085357, PMID 25317870, PMID 25355819, PMID 25444722, PMID 26213141, PMID 26451310, PMID 26764356, PMID 26853648, PMID 26943915, PMID 28270022, PMID 28314788, PMID 28424162, PMID 28817727, PMID 29074501, PMID 29263894, PMID 29292843, PMID 29572391, PMID 29599530, PMID 30454872, PMID 30562587, PMID 31076448, PMID 31388792, PMID 31481800, PMID 31617432, PMID 31815579, PMID 32245502, PMID 32430507, PMID 32628342, PMID 33420905, PMID 33492438, PMID 36282798, PMID 39161543, PMID 41804087
P30CA015704 (13), P30CA015083 (7), U01CA062502 (6), U01CA062505 (6), U01CA062487 (5), U01CA062491 (5), U01CA076576 (5), U01CA099168 (5), N01CM62202 (4), P01CA018029 (4), P30CA033572 (4), N01CM62201 (3), P01CA044991 (3), P01CA078902 (3), P30CA016058 (3)