8 completed, 1 active not recruiting, 1 terminated. 10 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 8, Active not recruiting 1, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
Follow Recurrent Childhood Ependymoma: new trials by email Literature Review of Recurrent Childhood Ependymoma trials Research Report on Recurrent Childhood Ependymoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) Laboratory Biomarker Analysis, Palbociclib, Pharmacological Study - Advanced Malignant Solid Neoplasm, Recurrent Childhood Ependymoma | Phase 2 | Completed | National Cancer Institute (NCI) | 23 | 2018-08-13 | 2026-04-03 |
| Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Bone Scan - Advanced Malignant Solid Neoplasm, Recurrent Childhood Ependymoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 20 | 2018-06-05 | 2026-10-16 |
| Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) Olaparib - Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 6 | 2017-09-14 | 2024-12-11 |
| Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors Intra thecal methotrexate, topotecan, cyclophosphamide - Recurrent Childhood Medulloblastoma, Recurrent Childhood Ependymoma | Phase 2 | Terminated | Nicklaus Children's Hospital f/k/a Miami Children's Hospital | 3 | 2016-02-01 | 2020-01-10 |
| Everolimus for Children With Recurrent or Progressive Ependymoma Everolimus - Recurrent Childhood Ependymoma | Phase 2 | Completed | University of Texas Southwestern Medical Center | 11 | 2015-02-01 | 2024-05-08 |
| Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or Ependymoma Diagnostic Laboratory Biomarker Analysis, Pharmacological Study, Sunitinib Malate - Childhood Cerebellar Anaplastic Astrocytoma, Childhood Cerebral Anaplastic Astrocytoma | Phase 2 | Completed | National Cancer Institute (NCI) | 30 | 2012-01-01 | 2015-08-27 |
| Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma Bevacizumab, Fludeoxyglucose F-18, Irinotecan Hydrochloride - Childhood Cerebral Anaplastic Astrocytoma, Childhood Oligodendroglioma | Phase 2 | Completed | National Cancer Institute (NCI) | 97 | 2006-08-01 | 2017-11-28 |
| Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment oxaliplatin - Childhood Central Nervous System Germ Cell Tumor, Childhood Extragonadal Germ Cell Tumor | Phase 2 | Completed | National Cancer Institute (NCI) | 180 | 2004-10-01 | 2013-06-05 |
| Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors lapatinib ditosylate, therapeutic conventional surgery, laboratory biomarker analysis - Recurrent Childhood Anaplastic Astrocytoma, Recurrent Childhood Brain Stem Glioma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 52 | 2004-10-01 | 2014-05-23 |
| Irinotecan in Treating Children With Refractory Solid Tumors irinotecan hydrochloride - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 2 | Completed | Children's Oncology Group | 181 | 1999-10-01 | 2013-06-14 |
Familial ependymoma (10) · Medulloblastoma (7) · Ependymoma (5) · Neuroblastoma (5) · Neuroectodermal Tumors, Primitive, Peripheral (5) · Astrocytoma (4) · Hepatoblastoma (4) · Oligodendroglioma (4) · Osteosarcoma (4) · Rhabdoid Tumor (4) · Glioma (3) · Histiocytosis, Langerhans-Cell (3) · Lymphoma, Non-Hodgkin (3) · Wilms Tumor (3) · Central Nervous System Neoplasms (2)
Neoplasms (10) · Neoplasms by Histologic Type (10) · Neoplasms, Germ Cell and Embryonal (10) · Neoplasms, Glandular and Epithelial (10) · Neoplasms, Nerve Tissue (10) · Neoplasms, Neuroepithelial (10) · Neuroectodermal Tumors (10) · Glioma (7) · Neoplasms by Site (7) · Neuroectodermal Tumors, Primitive (7) · Nervous System Diseases (6) · Nervous System Neoplasms (6) · Neoplasms, Complex and Mixed (5) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4)
Irinotecan (2) · Magnetic Resonance Spectroscopy (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Bevacizumab (1) · Biopsy (1) · Cyclophosphamide (1) · Disulfides (1) · Everolimus (1) · Fluorodeoxyglucose F18 (1) · Immunoglobulin G (1) · Lapatinib (1) · N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl-6-(5-((methylsulfonyl)ethyl)aminomethyl)-2-furyl)-4-quinazolinamine (1) · Nuclear Medicine Department, Hospital (1) · Oxaliplatin (1) · Phantoms, Imaging (1)
National Cancer Institute (NCI) (7) · Children's Oncology Group (1) · Nicklaus Children's Hospital f/k/a Miami Children's Hospital (1) · University of Texas Southwestern Medical Center (1)
United States (10) · Puerto Rico (3) · Australia (1) · Canada (1)
Alice Lee (1) · Cynthia Wetmore (1) · Daniel C Bowers, MD (1) · Julia Glade-Bender (1) · Lisa Bomgaars (1) · Maryam Fouladi (1) · Orren Beaty (1) · Rajen Mody (1) · Sridharan Gururangan (1) · Ziad Khatib, MD (1)
PMID 31401903, PMID 18447671, PMID 27109549, PMID 32623479, PMID 33852135, PMID 36950217, PMID 38815151, PMID 39298716
U10CA098543 (3), U10CA180886 (3), U01CA081457 (2), UM1CA081457 (1)