55 completed, 9 terminated, 4 recruiting, 1 active not recruiting. 35 Phase 2, 30 Phase 1, 7 Not applicable, 5 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 35 | Completed 29, Terminated 5, Active not recruiting 1 |
| Phase 1 | 30 | Completed 17, Terminated 8, Recruiting 4, Withdrawn 1 |
| Not applicable | 7 | Completed 7 |
| Phase 3 | 5 | Completed 5 |
Follow Recurrent Childhood Acute Myeloid Leukemia: new trials by email Literature Review of Recurrent Childhood Acute Myeloid Leukemia trials Research Report on Recurrent Childhood Acute Myeloid Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FH-FOLR1 Chimeric Antigen Receptor T Cell Therapy for Treating Pediatric Patients With Relapsed or Refractory Acute Myeloid Leukemia FOLR1 CAR T-cells, Biospecimen Collection, Bone Marrow Aspiration - Recurrent Childhood Acute Myeloid Leukemia, Refractory Childhood Acute Myeloid Leukemia | Phase 1 | Recruiting | Fred Hutchinson Cancer Center | 12 | 2025-02-24 | 2026-08-06 |
| A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Myelodysplastic Syndrome | Phase 1 | Recruiting | Children's Oncology Group | 36 | 2025-02-04 | 2026-08-25 |
| Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling Functional Precision Medicine - Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia | Phase 1 | Recruiting | Florida International University | 65 | 2023-02-22 | 2026-08-26 |
| Daratumumab and Donor Lymphocyte Infusion in Treating Participants With Relapsed Acute Myeloid Leukemia After Stem Cell Transplant Daratumumab, Donor Lymphocyte Infusion, Laboratory Biomarker Analysis - Minimal Residual Disease, Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes | Phase 1 / Phase 2 | Terminated | Sumithira Vasu | 4 | 2020-01-10 | 2025-05-21 |
| Ex Vivo Drug Sensitivity Testing and Mutation Profiling Recurrent Childhood Acute Myeloid Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia | Completed | Florida International University | 25 | 2019-02-21 | 2023-05-10 | |
| HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant CD8+ and CD4+ Donor Memory T-cells-expressing HA1-Specific TCR, Bone Marrow Aspiration, Biospecimen Collection - Juvenile Myelomonocytic Leukemia, Recurrent Acute Biphenotypic Leukemia | Phase 1 | Recruiting | Fred Hutchinson Cancer Center | 24 | 2018-02-23 | 2026-05-18 |
| Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children, Adolescents and Young Adults With Relapsed or Refractory Acute Myeloid Leukemia Cytarabine, Filgrastim, Fludarabine Phosphate - CNS 2a, CNS 2b | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2017-05-25 | 2017-05-03 | |
| Liposome-encapsulated Daunorubicin-Cytarabine, Fludarabine Phosphate, Cytarabine, and Filgrastim in Treating Younger Patients With Relapsed or Refractory Acute Myeloid Leukemia Cytarabine, Filgrastim, Fludarabine Phosphate - Acute Myeloid Leukemia Post Cytotoxic Therapy, Recurrent Childhood Acute Myeloid Leukemia | Phase 1 / Phase 2 | Completed | Children's Oncology Group | 38 | 2016-05-02 | 2023-09-08 |
| Sirolimus and Mycophenolate Mofetil in Preventing GVHD in Patients With Hematologic Malignancies Undergoing HSCT Allogeneic Hematopoietic Stem Cell Transplantation, Laboratory Biomarker Analysis, Mycophenolate Mofetil - Adult Hodgkin Lymphoma, Adult Myelodysplastic Syndrome | Phase 1 | Terminated | Stanford University | 1 | 2016-02-01 | 2018-09-12 |
| Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia Bone Marrow Transplantation, Cyclophosphamide, Fludarabine Phosphate - Adult Acute Lymphoblastic Leukemia in Complete Remission, Acute Myeloid Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 31 | 2015-06-25 | 2025-06-22 |
| Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Fludarabine Phosphate - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 84 | 2015-03-23 | 2026-06-01 |
| Total Marrow and Lymphoid Irradiation and Chemotherapy Before DSCT in Treating Patients With High-Risk ALL or AML etoposide, cyclophosphamide, total marrow irradiation - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 2 | Active not recruiting | City of Hope Medical Center | 108 | 2014-05-12 | 2026-07-01 |
| Azacitidine and Sonidegib or Decitabine in Treating Patients With Myeloid Malignancies Azacitidine, Decitabine, Laboratory Biomarker Analysis - Chronic Myelomonocytic Leukemia, de Novo Myelodysplastic Syndrome | Phase 1 | Completed | Mayo Clinic | 63 | 2014-05-01 | 2019-10-30 |
| Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine Phosphate, Laboratory Biomarker Analysis - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 20 | 2014-04-10 | 2024-03-12 |
| Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant Chlorhexidine Gluconate Skin Cleanser, Laboratory Biomarker Analysis, Mild Soap Skin Cleanser - Bacterial Infection, Benign Neoplasm | Phase 3 | Completed | Children's Oncology Group | 177 | 2013-11-04 | 2021-06-22 |
| AR-42 and Decitabine in Treating Patients With Acute Myeloid Leukemia HDAC inhibitor AR-42, decitabine, laboratory biomarker analysis - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q) | Phase 1 | Completed | Alison Walker | 13 | 2013-09-17 | 2018-03-14 |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia mitoxantrone hydrochloride, cytarabine, peripheral blood stem cell transplantation - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a) | Phase 1 | Terminated | University of Southern California | 10 | 2013-03-06 | 2018-03-30 |
| Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in With High-Risk Hematologic Malignancies Fludarabine phosphate, Busulfan, Total-Body Irradiation - Acute Myeloid Leukemia With FLT3/ITD Mutation, Acute Myeloid Leukemia With Gene Mutations | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 62 | 2012-12-24 | 2025-10-30 |
| Laboratory-Treated T Cells in Treating Patients With High-Risk Relapsed Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia Previously Treated With Donor Stem Cell Transplant Aldesleukin, Cyclophosphamide, Fludarabine Phosphate - Recurrent Adult Acute Myeloid Leukemia, Recurrent Childhood Acute Myeloid Leukemia | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 47 | 2012-12-06 | 2022-07-14 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (48) · Leukemia, Myeloid, Acute (47) · Congenital Abnormalities (28) · Leukemia, Lymphocytic, Chronic, B-Cell (24) · Dendritic Cell Sarcoma, Interdigitating (23) · Blast Crisis (22) · Burkitt Lymphoma (22) · Recurrence (22) · Leukemia, Myelomonocytic, Chronic (21) · Lymphoma, Large B-Cell, Diffuse (21) · Lymphoma, Non-Hodgkin (21) · Hodgkin Disease (20) · Lymphoma, Follicular (19) · Leukemia, Myeloid, Accelerated Phase (18) · Lymphoma, B-Cell, Marginal Zone (18)
Hematologic Diseases (69) · Hemic and Lymphatic Diseases (69) · Neoplasms by Histologic Type (69) · Neoplasms (67) · Leukemia (66) · Leukemia, Myeloid (59) · Immune System Diseases (49) · Immunoproliferative Disorders (49) · Leukemia, Lymphoid (49) · Lymphatic Diseases (49) · Lymphoproliferative Disorders (49) · Bone Marrow Diseases (48) · Pathological Conditions, Signs and Symptoms (47) · Pathologic Processes (46) · Disease Attributes (45)
Peripheral Blood Stem Cell Transplantation (26) · fludarabine phosphate (26) · Whole-Body Irradiation (21) · Mycophenolic Acid (20) · Cyclosporine (14) · Cyclophosphamide (13) · Busulfan (12) · Tacrolimus (12) · Methotrexate (9) · merphos (9) · Transplantation (7) · Cytarabine (5) · Etoposide (5) · Flow Cytometry (5) · Cyclosporins (4)
Fred Hutchinson Cancer Center (26) · National Cancer Institute (NCI) (14) · Children's Oncology Group (10) · City of Hope Medical Center (3) · Roswell Park Cancer Institute (3) · Case Comprehensive Cancer Center (2) · Florida International University (2) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (2) · Wake Forest University Health Sciences (2) · Alison Walker (1) · Masonic Cancer Center, University of Minnesota (1) · Mayo Clinic (1) · Stanford University (1) · Sumithira Vasu (1) · University of Chicago (1)
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Brenda Sandmaier (6) · David Maloney (3) · Maryam Fouladi (3) · Anthony Stein (2) · Bart Scott (2) · George Chen (2) · Marco Mielcarek (2) · Marie Bleakley (2) · Alexandra M Stevens (1) · Alison Walker, MD (1) · Andrew Rezvani (1) · Ann Mohrbacher (1) · Aref Al-Kali (1) · Aude Chapuis (1) · Boglarka Gyurkocza (1)
PMID 32499241, PMID 35007144, PMID 19900571, PMID 23393050, PMID 23660685, PMID 25085357, PMID 26764356, PMID 26943915, PMID 28817727, PMID 29042364, PMID 30777875, PMID 31235963, PMID 31688884, PMID 32401633, PMID 34400362, PMID 34435684, PMID 34738048, PMID 38605166, PMID 38683966, PMID 42080799, PMID 42150590, PMID 42500906
P30CA015704 (15), P01CA018029 (13), U01CA097452 (8), U10CA098543 (6), P01CA078902 (4), P01HL036444 (4), U10CA095861 (4), R01HL121568 (2), UG1CA189955 (2), K23CA154532 (1), K23HL084054 (1), P30CA012197 (1), P30CA015083 (1), P30CA016056 (1), R01CA154491 (1)