4 completed, 4 unknown, 1 recruiting, 1 terminated. 5 Phase 1, 4 Phase 2, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 3, Unknown 2 |
| Phase 2 | 4 | Completed 1, Terminated 1, Unknown 1, Withdrawn 1 |
| Phase 3 | 2 | Recruiting 1, Withdrawn 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Radiation Retinopathy: new trials by email Literature Review of Radiation Retinopathy trials Research Report on Radiation Retinopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy Faricimab, fluocinolone acetonide - Radiation Retinopathy, Visual Impairment | Phase 3 | Recruiting | Jaeb Center for Health Research | 600 | 2023-11-21 | 2026-10-23 |
| Steroids for Early Treatment of Radiation Retinopathy Fluocinolone Acetonide (FA) implant - Radiation Retinopathy | Phase 2 / Phase 3 | Withdrawn | The Cleveland Clinic | 2022-02-01 | 2021-08-04 | |
| Phase I Study of Episcleral Celecoxib for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole Episcleral Celecoxib - Macula Edema, Radiation Retinopathy | Phase 1 | Unknown | Targeted Therapy Technologies, LLC | 3 | 2021-03-05 | 2023-11-24 |
| Episcleral Dexamethasone for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole Episcleral Dexamethasone - Macular Edema, Radiation Retinopathy | Phase 1 | Unknown | Targeted Therapy Technologies, LLC | 2 | 2019-09-01 | 2023-11-24 |
| Intravitreal Aflibercept Injection for Radiation Retinopathy Trial Aflibercept - Radiation Retinopathy | Phase 2 | Unknown | Amy C Schefler, MD | 40 | 2017-07-05 | 2020-12-08 |
| Study of the Efficacy and Tolerability of Intravitreal Injections of Ranibizumab Compared to Intravitreal Injections of Ranibizumab Combined With Targeted Retinal Photocoagulation to Treat Radiation Retinopathy. 0.5 mg ranibizumab, Targeted Retinal Photocoagulation (TRP) - Radiation Retinopathy | Phase 2 | Completed | Greater Houston Retina Research | 40 | 2014-09-23 | 2021-03-25 |
| Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma Ozurdex, Bevacizumab - Macular Edema, Cystoid Macular Edema | Phase 2 | Terminated | Arman Mashayekhi | 6 | 2014-04-01 | 2019-09-03 |
| Intravitreal Aflibercept Injection for Radiation Retinopathy Aflibercept every 2 months, Aflibercept monthly - Radiation Retinopathy, Macular Edema | Phase 1 | Completed | Washington University School of Medicine | 9 | 2012-11-01 | 2019-04-25 |
| High Dose Intravitreal Ranibizumab for Recalcitrant Radiation Retinopathy ranibizumab 2.0 mg - Radiation Retinopathy | Phase 1 | Completed | The New York Eye Cancer Center | 10 | 2011-05-01 | 2014-10-02 |
| Effect of Intravitreal Ranibizumab on Radiation Retinopathy Following Plaque Brachytherapy for Choroidal Melanoma Ranibizumab, ranibizumab - Radiation Retinopathy, Choroidal Melanoma | Phase 1 | Completed | The New York Eye Cancer Center | 10 | 2008-10-01 | 2012-04-26 |
| Intravitreal Ranibizumab for the Prevention of Radiation Maculopathy Following Plaque Radiotherapy Ranibizumab - Uveal Melanoma, Radiation Retinopathy | Phase 4 | Unknown | Shields, Shields and Associates | 400 | 2007-04-01 | 2007-10-08 |
Macular Edema (3) · Retinal Diseases (3) · Uveal Melanoma (3) · Epiretinal Membrane (2) · Retinal Vein Occlusion (2) · Uveitis, Intermediate (2) · Melanoma (1) · Vision Disorders (1)
Eye Diseases (8) · Uveal Diseases (5) · Eye Neoplasms (3) · Macular Degeneration (3) · Neoplasms (3) · Neoplasms by Histologic Type (3) · Neoplasms by Site (3) · Neoplasms, Germ Cell and Embryonal (3) · Neoplasms, Nerve Tissue (3) · Neuroectodermal Tumors (3) · Neuroendocrine Tumors (3) · Nevi and Melanomas (3) · Retinal Degeneration (3) · Retinal Diseases (3) · Uveal Neoplasms (3)
Ranibizumab (4) · Fluocinolone Acetonide (2) · aflibercept (2) · Bevacizumab (1) · Calcium Dobesilate (1) · Dexamethasone (1) · Steroids (1) · faricimab (1)
Targeted Therapy Technologies, LLC (2) · The New York Eye Cancer Center (2) · Amy C Schefler, MD (1) · Arman Mashayekhi (1) · Greater Houston Retina Research (1) · Jaeb Center for Health Research (1) · Shields, Shields and Associates (1) · The Cleveland Clinic (1) · Washington University School of Medicine (1)
United States (11)
Amy C Schefler, MD (2) · Paul T Finger, MD (2) · Theodore Leng, MD (2) · Armen Mashayekhi, MD (1) · Carol L Shields, MD (1) · Prabakar K Rao, MD (1)
PMID 20142553, PMID 34463842, PMID 36912792
UG1EY014231 (1)