2 not yet recruiting, 2 withdrawn, 1 active not recruiting, 1 completed. 3 Phase 1, 2 Phase 2, 1 Early Phase 1, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Not yet recruiting 2, Withdrawn 1 |
| Phase 2 | 2 | Not yet recruiting 1, Withdrawn 1 |
| Early Phase 1 | 1 | Withdrawn 1 |
| Not applicable | 1 | Completed 1 |
| Phase 3 | 1 | Active not recruiting 1 |
Follow Progressive Multiple Sclerosis (PMS): new trials by email Literature Review of Progressive Multiple Sclerosis (PMS) trials Research Report on Progressive Multiple Sclerosis (PMS)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Basket Study of CTA313 in Participants With Active Autoimmune Diseases CTA313 UCAR T Cell Infusion - Systemic Lupus Erthematosus (SLE), Progressive Multiple Sclerosis (PMS) | Phase 1 | Not yet recruiting | Imviva Bio | 81 | 2026-12-01 | 2026-08-24 |
| A Safety and Efficacy Study Evaluating CTX112 in Subjects With Refractory Neurologic Autoimmune Disease CTX112 - Progressive Multiple Sclerosis (PMS), Neuromyelitis Optica | Phase 1 / Phase 2 | Not yet recruiting | CRISPR Therapeutics | 220 | 2026-11-01 | 2026-10-22 |
| A Clinical Study to Evaluate LVIVO-TaVec400 for the Treatment of Relapsed/Refractory Autoimmune Diseases LVIVO-TaVec400 product - Relapsed/Refractory Systemic Lupus Erythematosus (r/r SLE), Relapsed/Refractory IgG4-Related Disease (r/r IgG4-RD) | Early Phase 1 | Withdrawn | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 2026-09-23 | 2026-10-02 | |
| RESET-MS: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Multiple Sclerosis CABA-201 - Relapsing Multiple Sclerosis (RMS), Progressive Multiple Sclerosis (PMS) | Phase 1 / Phase 2 | Withdrawn | Cabaletta Bio | 2026-06-01 | 2026-06-25 | |
| The Effects of a 12-week In-phase Bilateral Exercise Programme on the Corticospinal Plasticity in People With Progressive Multiple Sclerosis In-Phase Bilateral Upper Limb Exercise Program - Progressive Multiple Sclerosis (PMS) | Not applicable | Completed | Marinos Chatzikonstantinou | 5 | 2025-02-01 | 2026-04-23 |
| A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis Ocrelizumab - Progressive Multiple Sclerosis (PMS) | Phase 3 | Active not recruiting | Hoffmann-La Roche | 927 | 2018-05-28 | 2026-07-23 |
Multiple Sclerosis, Chronic Progressive (6) · Autoimmune Diseases (2) · Autoimmune Diseases of the Nervous System (2) · Immunoglobulin G4-Related Disease (1) · Lupus Erythematosus, Systemic (1) · Multiple Sclerosis (1) · Multiple Sclerosis, Relapsing-Remitting (1) · Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (1) · Neuromyelitis Optica (1) · Recurrence (1) · Stiff-Person Syndrome (1)
Chronic Disease (6) · Demyelinating Autoimmune Diseases, CNS (6) · Demyelinating Diseases (6) · Disease Attributes (6) · Immune System Diseases (6) · Nervous System Diseases (6) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Multiple Sclerosis (5) · Autoimmune Diseases (4) · Autoimmune Diseases of the Nervous System (4) · Central Nervous System Diseases (1) · Connective Tissue Diseases (1) · Cranial Nerve Diseases (1) · Eye Diseases (1)
ocrelizumab (1)
CRISPR Therapeutics (1) · Cabaletta Bio (1) · Hoffmann-La Roche (1) · Imviva Bio (1) · Marinos Chatzikonstantinou (1) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (1)
Bosnia and Herzegovina (1) · Brazil (1) · Canada (1) · China (1) · Colombia (1) · Costa Rica (1) · Cyprus (1) · Czechia (1) · Denmark (1) · Egypt (1) · France (1) · Germany (1) · Guatemala (1) · Hungary (1) · Ireland (1)
Qiubai Li (1)
2017 (1), 2023 (1)